Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/DNAJC15_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DNAJC15_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DNAJC15_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/DNAJC15_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DNAJC15_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DNAJC15_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DNAJC15_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DNAJC15_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DNAJC15_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
GO:00705859 | Cervix | CC | protein localization to mitochondrion | 33/2311 | 125/18723 | 1.46e-05 | 2.90e-04 | 33 |
GO:00313339 | Cervix | CC | negative regulation of protein-containing complex assembly | 35/2311 | 141/18723 | 3.41e-05 | 5.55e-04 | 35 |
GO:00726559 | Cervix | CC | establishment of protein localization to mitochondrion | 31/2311 | 120/18723 | 4.13e-05 | 6.36e-04 | 31 |
GO:19905428 | Cervix | CC | mitochondrial transmembrane transport | 26/2311 | 102/18723 | 2.10e-04 | 2.39e-03 | 26 |
GO:00066269 | Cervix | CC | protein targeting to mitochondrion | 25/2311 | 100/18723 | 3.80e-04 | 3.89e-03 | 25 |
GO:004603425 | Cervix | N_HPV | ATP metabolic process | 40/534 | 277/18723 | 2.37e-17 | 5.40e-14 | 40 |
GO:000611924 | Cervix | N_HPV | oxidative phosphorylation | 24/534 | 141/18723 | 1.74e-12 | 2.64e-09 | 24 |
GO:000906024 | Cervix | N_HPV | aerobic respiration | 24/534 | 189/18723 | 9.57e-10 | 4.84e-07 | 24 |
GO:004277324 | Cervix | N_HPV | ATP synthesis coupled electron transport | 17/534 | 95/18723 | 1.39e-09 | 5.76e-07 | 17 |
GO:004277524 | Cervix | N_HPV | mitochondrial ATP synthesis coupled electron transport | 17/534 | 95/18723 | 1.39e-09 | 5.76e-07 | 17 |
GO:000609124 | Cervix | N_HPV | generation of precursor metabolites and energy | 40/534 | 490/18723 | 2.59e-09 | 7.88e-07 | 40 |
GO:001964624 | Cervix | N_HPV | aerobic electron transport chain | 16/534 | 87/18723 | 2.80e-09 | 7.98e-07 | 16 |
GO:004533324 | Cervix | N_HPV | cellular respiration | 25/534 | 230/18723 | 1.10e-08 | 1.85e-06 | 25 |
GO:000612024 | Cervix | N_HPV | mitochondrial electron transport, NADH to ubiquinone | 12/534 | 51/18723 | 1.48e-08 | 2.40e-06 | 12 |
GO:002290424 | Cervix | N_HPV | respiratory electron transport chain | 17/534 | 114/18723 | 2.45e-08 | 3.18e-06 | 17 |
GO:002290024 | Cervix | N_HPV | electron transport chain | 21/534 | 175/18723 | 2.95e-08 | 3.63e-06 | 21 |
GO:003133323 | Cervix | N_HPV | negative regulation of protein-containing complex assembly | 17/534 | 141/18723 | 5.73e-07 | 3.57e-05 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC15 | SNV | Missense_Mutation | novel | c.22G>T | p.Ala8Ser | p.A8S | Q9Y5T4 | protein_coding | tolerated_low_confidence(0.24) | benign(0.049) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DNAJC15 | SNV | Missense_Mutation | rs756868611 | c.68C>T | p.Ser23Leu | p.S23L | Q9Y5T4 | protein_coding | deleterious_low_confidence(0.03) | benign(0.017) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | | c.43C>T | p.Arg15Cys | p.R15C | Q9Y5T4 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | novel | c.269N>C | p.Gln90Pro | p.Q90P | Q9Y5T4 | protein_coding | tolerated(0.69) | benign(0.011) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | novel | c.215N>T | p.Ala72Val | p.A72V | Q9Y5T4 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | rs115803506 | c.284N>A | p.Arg95Gln | p.R95Q | Q9Y5T4 | protein_coding | tolerated(0.09) | probably_damaging(0.98) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
DNAJC15 | SNV | Missense_Mutation | | c.450T>G | p.His150Gln | p.H150Q | Q9Y5T4 | protein_coding | tolerated_low_confidence(0.19) | benign(0.007) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | | c.369N>G | p.Asn123Lys | p.N123K | Q9Y5T4 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DNAJC15 | SNV | Missense_Mutation | rs765899911 | c.163N>T | p.Arg55Cys | p.R55C | Q9Y5T4 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DNAJC15 | SNV | Missense_Mutation | rs760852761 | c.407N>G | p.Lys136Arg | p.K136R | Q9Y5T4 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |