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Gene: DNAAF4 |
Gene summary for DNAAF4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DNAAF4 | Gene ID | 161582 |
| Gene name | dynein axonemal assembly factor 4 | |
| Gene Alias | CILD25 | |
| Cytomap | 15q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8WXU2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 161582 | DNAAF4 | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 2.30e-04 | 1.00e+00 | 0.0057 |
| 161582 | DNAAF4 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 6.52e-01 | -0.0263 |
| 161582 | DNAAF4 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.51e-02 | 1.80e-01 | -0.0166 |
| 161582 | DNAAF4 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.06e-02 | 1.73e-01 | -0.0132 |
| 161582 | DNAAF4 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.32e-03 | 1.96e-01 | -0.013 |
| 161582 | DNAAF4 | PTC01 | Human | Thyroid | PTC | 2.61e-10 | 2.04e-01 | 0.1899 |
| 161582 | DNAAF4 | PTC03 | Human | Thyroid | PTC | 9.50e-07 | 2.71e-01 | 0.1784 |
| 161582 | DNAAF4 | PTC04 | Human | Thyroid | PTC | 5.96e-08 | 1.48e-01 | 0.1927 |
| 161582 | DNAAF4 | PTC05 | Human | Thyroid | PTC | 6.87e-11 | 3.66e-01 | 0.2065 |
| 161582 | DNAAF4 | PTC06 | Human | Thyroid | PTC | 1.13e-17 | 4.23e-01 | 0.2057 |
| 161582 | DNAAF4 | PTC07 | Human | Thyroid | PTC | 6.99e-29 | 4.95e-01 | 0.2044 |
| 161582 | DNAAF4 | ATC11 | Human | Thyroid | ATC | 7.49e-03 | 2.55e-01 | 0.3386 |
| 161582 | DNAAF4 | ATC12 | Human | Thyroid | ATC | 5.14e-03 | 9.59e-02 | 0.34 |
| 161582 | DNAAF4 | ATC13 | Human | Thyroid | ATC | 1.28e-06 | 1.52e-01 | 0.34 |
| 161582 | DNAAF4 | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 2.13e-01 | 0.338 |
| 161582 | DNAAF4 | ATC4 | Human | Thyroid | ATC | 1.21e-03 | 1.15e-01 | 0.34 |
| 161582 | DNAAF4 | ATC5 | Human | Thyroid | ATC | 1.28e-06 | 1.62e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00602711 | Lung | MIAC | cilium assembly | 37/967 | 337/18723 | 1.29e-05 | 9.85e-04 | 37 |
| GO:00447821 | Lung | MIAC | cilium organization | 38/967 | 368/18723 | 3.93e-05 | 2.08e-03 | 38 |
| GO:007138323 | Lung | MIAC | cellular response to steroid hormone stimulus | 25/967 | 204/18723 | 5.46e-05 | 2.75e-03 | 25 |
| GO:004854523 | Lung | MIAC | response to steroid hormone | 34/967 | 339/18723 | 1.73e-04 | 6.42e-03 | 34 |
| GO:003052223 | Lung | MIAC | intracellular receptor signaling pathway | 27/967 | 265/18723 | 6.08e-04 | 1.50e-02 | 27 |
| GO:006113623 | Lung | MIAC | regulation of proteasomal protein catabolic process | 21/967 | 187/18723 | 6.85e-04 | 1.59e-02 | 21 |
| GO:003314322 | Lung | MIAC | regulation of intracellular steroid hormone receptor signaling pathway | 11/967 | 74/18723 | 1.39e-03 | 2.51e-02 | 11 |
| GO:003051822 | Lung | MIAC | intracellular steroid hormone receptor signaling pathway | 14/967 | 116/18723 | 2.62e-03 | 3.71e-02 | 14 |
| GO:001049823 | Lung | MIAC | proteasomal protein catabolic process | 40/967 | 490/18723 | 2.92e-03 | 3.99e-02 | 40 |
| GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
| GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
| GO:1903362113 | Thyroid | PTC | regulation of cellular protein catabolic process | 162/5968 | 255/18723 | 1.62e-25 | 5.12e-23 | 162 |
| GO:1903050113 | Thyroid | PTC | regulation of proteolysis involved in cellular protein catabolic process | 140/5968 | 221/18723 | 4.63e-22 | 1.01e-19 | 140 |
| GO:0061136113 | Thyroid | PTC | regulation of proteasomal protein catabolic process | 121/5968 | 187/18723 | 2.25e-20 | 3.37e-18 | 121 |
| GO:0048545113 | Thyroid | PTC | response to steroid hormone | 158/5968 | 339/18723 | 8.10e-09 | 2.00e-07 | 158 |
| GO:003052228 | Thyroid | PTC | intracellular receptor signaling pathway | 126/5968 | 265/18723 | 6.31e-08 | 1.31e-06 | 126 |
| GO:0030518111 | Thyroid | PTC | intracellular steroid hormone receptor signaling pathway | 63/5968 | 116/18723 | 4.53e-07 | 7.41e-06 | 63 |
| GO:0071383112 | Thyroid | PTC | cellular response to steroid hormone stimulus | 98/5968 | 204/18723 | 9.83e-07 | 1.47e-05 | 98 |
| GO:004340124 | Thyroid | PTC | steroid hormone mediated signaling pathway | 69/5968 | 136/18723 | 3.57e-06 | 4.58e-05 | 69 |
| GO:003314310 | Thyroid | PTC | regulation of intracellular steroid hormone receptor signaling pathway | 42/5968 | 74/18723 | 8.40e-06 | 9.62e-05 | 42 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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