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Gene: DMAC1 |
Gene summary for DMAC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DMAC1 | Gene ID | 90871 |
Gene name | distal membrane arm assembly component 1 | |
Gene Alias | C9orf123 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96GE9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90871 | DMAC1 | GSM4909281 | Human | Breast | IDC | 1.18e-07 | 3.67e-01 | 0.21 |
90871 | DMAC1 | GSM4909282 | Human | Breast | IDC | 3.15e-34 | 7.05e-01 | -0.0288 |
90871 | DMAC1 | GSM4909285 | Human | Breast | IDC | 2.13e-18 | 4.94e-01 | 0.21 |
90871 | DMAC1 | GSM4909286 | Human | Breast | IDC | 2.83e-15 | 3.18e-01 | 0.1081 |
90871 | DMAC1 | GSM4909287 | Human | Breast | IDC | 3.82e-07 | 4.00e-01 | 0.2057 |
90871 | DMAC1 | GSM4909289 | Human | Breast | IDC | 4.56e-02 | 4.14e-01 | 0.1064 |
90871 | DMAC1 | GSM4909290 | Human | Breast | IDC | 5.68e-46 | 1.01e+00 | 0.2096 |
90871 | DMAC1 | GSM4909293 | Human | Breast | IDC | 5.99e-26 | 6.15e-01 | 0.1581 |
90871 | DMAC1 | GSM4909298 | Human | Breast | IDC | 1.65e-04 | 2.29e-01 | 0.1551 |
90871 | DMAC1 | GSM4909305 | Human | Breast | IDC | 2.32e-11 | 4.65e-01 | 0.0436 |
90871 | DMAC1 | GSM4909306 | Human | Breast | IDC | 3.57e-09 | 4.24e-01 | 0.1564 |
90871 | DMAC1 | GSM4909307 | Human | Breast | IDC | 5.60e-03 | 3.21e-01 | 0.1569 |
90871 | DMAC1 | GSM4909308 | Human | Breast | IDC | 1.71e-11 | 3.79e-01 | 0.158 |
90871 | DMAC1 | GSM4909311 | Human | Breast | IDC | 3.98e-11 | 1.29e-01 | 0.1534 |
90871 | DMAC1 | GSM4909319 | Human | Breast | IDC | 1.88e-12 | -3.14e-02 | 0.1563 |
90871 | DMAC1 | GSM4909321 | Human | Breast | IDC | 1.03e-02 | 7.71e-02 | 0.1559 |
90871 | DMAC1 | brca1 | Human | Breast | Precancer | 3.69e-10 | -1.89e-01 | -0.0338 |
90871 | DMAC1 | brca2 | Human | Breast | Precancer | 1.78e-08 | -1.89e-01 | -0.024 |
90871 | DMAC1 | brca3 | Human | Breast | Precancer | 1.79e-07 | -1.89e-01 | -0.0263 |
90871 | DMAC1 | DCIS2 | Human | Breast | DCIS | 1.70e-57 | 2.68e-01 | 0.0085 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003298120 | Esophagus | HGIN | mitochondrial respiratory chain complex I assembly | 31/2587 | 57/18723 | 5.89e-13 | 8.62e-11 | 31 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:001025712 | Liver | HCC | NADH dehydrogenase complex assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:003298112 | Liver | HCC | mitochondrial respiratory chain complex I assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:00102576 | Stomach | GC | NADH dehydrogenase complex assembly | 17/1159 | 57/18723 | 3.37e-08 | 2.44e-06 | 17 |
GO:00329816 | Stomach | GC | mitochondrial respiratory chain complex I assembly | 17/1159 | 57/18723 | 3.37e-08 | 2.44e-06 | 17 |
GO:00331086 | Stomach | GC | mitochondrial respiratory chain complex assembly | 22/1159 | 93/18723 | 3.77e-08 | 2.70e-06 | 22 |
GO:003310811 | Stomach | CAG with IM | mitochondrial respiratory chain complex assembly | 22/1050 | 93/18723 | 6.37e-09 | 6.07e-07 | 22 |
GO:001025711 | Stomach | CAG with IM | NADH dehydrogenase complex assembly | 17/1050 | 57/18723 | 7.82e-09 | 7.19e-07 | 17 |
GO:003298111 | Stomach | CAG with IM | mitochondrial respiratory chain complex I assembly | 17/1050 | 57/18723 | 7.82e-09 | 7.19e-07 | 17 |
GO:003310821 | Stomach | CSG | mitochondrial respiratory chain complex assembly | 22/1034 | 93/18723 | 4.81e-09 | 4.99e-07 | 22 |
GO:001025721 | Stomach | CSG | NADH dehydrogenase complex assembly | 17/1034 | 57/18723 | 6.22e-09 | 6.10e-07 | 17 |
GO:003298121 | Stomach | CSG | mitochondrial respiratory chain complex I assembly | 17/1034 | 57/18723 | 6.22e-09 | 6.10e-07 | 17 |
GO:0033108111 | Thyroid | PTC | mitochondrial respiratory chain complex assembly | 65/5968 | 93/18723 | 5.60e-14 | 3.21e-12 | 65 |
GO:0010257111 | Thyroid | PTC | NADH dehydrogenase complex assembly | 43/5968 | 57/18723 | 1.73e-11 | 6.81e-10 | 43 |
GO:0032981111 | Thyroid | PTC | mitochondrial respiratory chain complex I assembly | 43/5968 | 57/18723 | 1.73e-11 | 6.81e-10 | 43 |
GO:003310832 | Thyroid | ATC | mitochondrial respiratory chain complex assembly | 65/6293 | 93/18723 | 8.86e-13 | 3.81e-11 | 65 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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