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Gene: DDX18 |
Gene summary for DDX18 |
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Gene information | Species | Human | Gene symbol | DDX18 | Gene ID | 8886 |
Gene name | DEAD-box helicase 18 | |
Gene Alias | Has1 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000463 | UniProtAcc | A0A024RAH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8886 | DDX18 | CA_HPV_1 | Human | Cervix | CC | 2.13e-06 | -1.45e-01 | 0.0264 |
8886 | DDX18 | CCI_1 | Human | Cervix | CC | 1.17e-03 | -5.13e-01 | 0.528 |
8886 | DDX18 | CCI_3 | Human | Cervix | CC | 3.89e-03 | -4.47e-01 | 0.516 |
8886 | DDX18 | CCII_1 | Human | Cervix | CC | 2.55e-14 | -5.89e-01 | 0.3249 |
8886 | DDX18 | L1 | Human | Cervix | CC | 6.43e-07 | -3.51e-01 | 0.0802 |
8886 | DDX18 | T3 | Human | Cervix | CC | 3.88e-04 | -1.79e-01 | 0.1389 |
8886 | DDX18 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.80e-06 | 6.46e-01 | 0.281 |
8886 | DDX18 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.33e-04 | 5.30e-01 | 0.3859 |
8886 | DDX18 | A001-C-207 | Human | Colorectum | FAP | 3.15e-02 | -1.93e-01 | 0.1278 |
8886 | DDX18 | A015-C-203 | Human | Colorectum | FAP | 6.68e-14 | -1.53e-01 | -0.1294 |
8886 | DDX18 | A002-C-201 | Human | Colorectum | FAP | 1.74e-06 | -8.41e-02 | 0.0324 |
8886 | DDX18 | A001-C-119 | Human | Colorectum | FAP | 1.67e-02 | -2.03e-01 | -0.1557 |
8886 | DDX18 | A001-C-108 | Human | Colorectum | FAP | 6.03e-08 | -3.16e-02 | -0.0272 |
8886 | DDX18 | A002-C-205 | Human | Colorectum | FAP | 4.77e-11 | -4.32e-02 | -0.1236 |
8886 | DDX18 | A015-C-006 | Human | Colorectum | FAP | 2.64e-07 | 2.88e-02 | -0.0994 |
8886 | DDX18 | A015-C-106 | Human | Colorectum | FAP | 1.64e-04 | -2.44e-02 | -0.0511 |
8886 | DDX18 | A002-C-114 | Human | Colorectum | FAP | 2.84e-10 | -1.35e-01 | -0.1561 |
8886 | DDX18 | A015-C-104 | Human | Colorectum | FAP | 8.00e-14 | -7.18e-02 | -0.1899 |
8886 | DDX18 | A001-C-014 | Human | Colorectum | FAP | 3.77e-06 | 9.94e-02 | 0.0135 |
8886 | DDX18 | A002-C-016 | Human | Colorectum | FAP | 1.55e-09 | -6.50e-02 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:002261317 | Endometrium | EEC | ribonucleoprotein complex biogenesis | 108/2168 | 463/18723 | 4.60e-13 | 9.86e-11 | 108 |
GO:004227317 | Endometrium | EEC | ribosomal large subunit biogenesis | 30/2168 | 72/18723 | 8.19e-11 | 1.07e-08 | 30 |
GO:004225417 | Endometrium | EEC | ribosome biogenesis | 68/2168 | 299/18723 | 2.90e-08 | 1.68e-06 | 68 |
GO:000636416 | Endometrium | EEC | rRNA processing | 48/2168 | 225/18723 | 1.88e-05 | 3.50e-04 | 48 |
GO:003235514 | Endometrium | EEC | response to estradiol | 34/2168 | 141/18723 | 2.22e-05 | 3.98e-04 | 34 |
GO:000047013 | Endometrium | EEC | maturation of LSU-rRNA | 12/2168 | 28/18723 | 2.88e-05 | 5.03e-04 | 12 |
GO:001607216 | Endometrium | EEC | rRNA metabolic process | 49/2168 | 236/18723 | 3.27e-05 | 5.62e-04 | 49 |
GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:000047016 | Esophagus | ESCC | maturation of LSU-rRNA | 27/8552 | 28/18723 | 9.94e-09 | 2.00e-07 | 27 |
GO:00004634 | Esophagus | ESCC | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX18 | SNV | Missense_Mutation | novel | c.135N>C | p.Glu45Asp | p.E45D | Q9NVP1 | protein_coding | tolerated_low_confidence(0.29) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX18 | SNV | Missense_Mutation | c.1106N>A | p.Arg369Gln | p.R369Q | Q9NVP1 | protein_coding | tolerated(0.51) | benign(0.01) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.1117G>C | p.Asp373His | p.D373H | Q9NVP1 | protein_coding | deleterious(0) | benign(0.264) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DDX18 | SNV | Missense_Mutation | c.382N>A | p.Ala128Thr | p.A128T | Q9NVP1 | protein_coding | tolerated(0.21) | benign(0) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
DDX18 | SNV | Missense_Mutation | rs374687356 | c.1616G>A | p.Arg539His | p.R539H | Q9NVP1 | protein_coding | tolerated(0.06) | benign(0.015) | TCGA-LL-A6FQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX18 | SNV | Missense_Mutation | c.1117G>T | p.Asp373Tyr | p.D373Y | Q9NVP1 | protein_coding | deleterious(0) | benign(0.115) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DDX18 | SNV | Missense_Mutation | c.1460G>A | p.Arg487Lys | p.R487K | Q9NVP1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
DDX18 | SNV | Missense_Mutation | c.1696N>C | p.Glu566Gln | p.E566Q | Q9NVP1 | protein_coding | deleterious(0.01) | benign(0.098) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.1012N>C | p.Ile338Leu | p.I338L | Q9NVP1 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.769N>T | p.Leu257Phe | p.L257F | Q9NVP1 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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