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Gene: CTSZ |
Gene summary for CTSZ |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CTSZ | Gene ID | 1522 |
| Gene name | cathepsin Z | |
| Gene Alias | CTSX | |
| Cytomap | 20q13.32 | |
| Gene Type | protein-coding | GO ID | GO:0001763 | UniProtAcc | Q9UBR2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1522 | CTSZ | GSM4909293 | Human | Breast | IDC | 9.34e-03 | 2.37e-01 | 0.1581 |
| 1522 | CTSZ | GSM4909295 | Human | Breast | IDC | 6.67e-05 | 4.74e-01 | 0.0898 |
| 1522 | CTSZ | GSM4909297 | Human | Breast | IDC | 1.29e-03 | 8.63e-02 | 0.1517 |
| 1522 | CTSZ | GSM4909308 | Human | Breast | IDC | 2.55e-02 | 2.68e-01 | 0.158 |
| 1522 | CTSZ | GSM4909311 | Human | Breast | IDC | 1.38e-14 | -2.41e-02 | 0.1534 |
| 1522 | CTSZ | GSM4909319 | Human | Breast | IDC | 2.10e-19 | -6.62e-03 | 0.1563 |
| 1522 | CTSZ | GSM4909321 | Human | Breast | IDC | 1.25e-04 | 7.12e-02 | 0.1559 |
| 1522 | CTSZ | brca1 | Human | Breast | Precancer | 3.88e-03 | 2.42e-01 | -0.0338 |
| 1522 | CTSZ | NCCBC11 | Human | Breast | DCIS | 1.41e-05 | 2.69e-01 | 0.1232 |
| 1522 | CTSZ | NCCBC14 | Human | Breast | DCIS | 7.62e-15 | 2.34e-01 | 0.2021 |
| 1522 | CTSZ | NCCBC3 | Human | Breast | DCIS | 8.20e-22 | 7.02e-01 | 0.1198 |
| 1522 | CTSZ | NCCBC5 | Human | Breast | DCIS | 1.01e-08 | 2.32e-01 | 0.2046 |
| 1522 | CTSZ | P1 | Human | Breast | IDC | 1.92e-09 | 1.16e-02 | 0.1527 |
| 1522 | CTSZ | DCIS2 | Human | Breast | DCIS | 3.13e-75 | 7.29e-01 | 0.0085 |
| 1522 | CTSZ | CA_HPV_1 | Human | Cervix | CC | 1.50e-15 | 6.56e-01 | 0.0264 |
| 1522 | CTSZ | N_HPV_2 | Human | Cervix | N_HPV | 3.17e-02 | 2.78e-01 | -0.0131 |
| 1522 | CTSZ | CCI_1 | Human | Cervix | CC | 2.88e-02 | -5.11e-01 | 0.528 |
| 1522 | CTSZ | CCI_3 | Human | Cervix | CC | 1.93e-04 | -5.24e-01 | 0.516 |
| 1522 | CTSZ | CCII_1 | Human | Cervix | CC | 4.22e-07 | -5.26e-01 | 0.3249 |
| 1522 | CTSZ | Tumor | Human | Cervix | CC | 1.76e-02 | -2.15e-01 | 0.1241 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00303244 | Breast | IDC | lung development | 28/1434 | 177/18723 | 1.90e-04 | 3.15e-03 | 28 |
| GO:00303234 | Breast | IDC | respiratory tube development | 28/1434 | 181/18723 | 2.78e-04 | 4.26e-03 | 28 |
| GO:00611383 | Breast | IDC | morphogenesis of a branching epithelium | 28/1434 | 182/18723 | 3.05e-04 | 4.60e-03 | 28 |
| GO:00605412 | Breast | IDC | respiratory system development | 30/1434 | 203/18723 | 3.85e-04 | 5.40e-03 | 30 |
| GO:00017635 | Breast | IDC | morphogenesis of a branching structure | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
| GO:005110014 | Breast | IDC | negative regulation of binding | 25/1434 | 162/18723 | 5.98e-04 | 7.54e-03 | 25 |
| GO:004352513 | Breast | IDC | positive regulation of neuron apoptotic process | 12/1434 | 58/18723 | 1.27e-03 | 1.35e-02 | 12 |
| GO:0048754 | Breast | IDC | branching morphogenesis of an epithelial tube | 22/1434 | 151/18723 | 2.61e-03 | 2.34e-02 | 22 |
| GO:0060441 | Breast | IDC | epithelial tube branching involved in lung morphogenesis | 7/1434 | 29/18723 | 5.31e-03 | 3.94e-02 | 7 |
| GO:005160413 | Breast | IDC | protein maturation | 35/1434 | 294/18723 | 6.18e-03 | 4.40e-02 | 35 |
| GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
| GO:007099724 | Breast | DCIS | neuron death | 57/1390 | 361/18723 | 4.56e-08 | 2.84e-06 | 57 |
| GO:005140222 | Breast | DCIS | neuron apoptotic process | 43/1390 | 246/18723 | 1.16e-07 | 6.13e-06 | 43 |
| GO:005109823 | Breast | DCIS | regulation of binding | 55/1390 | 363/18723 | 3.14e-07 | 1.48e-05 | 55 |
| GO:190121421 | Breast | DCIS | regulation of neuron death | 48/1390 | 319/18723 | 2.13e-06 | 7.79e-05 | 48 |
| GO:004352321 | Breast | DCIS | regulation of neuron apoptotic process | 36/1390 | 212/18723 | 2.45e-06 | 8.68e-05 | 36 |
| GO:190121622 | Breast | DCIS | positive regulation of neuron death | 20/1390 | 97/18723 | 2.45e-05 | 5.68e-04 | 20 |
| GO:004352521 | Breast | DCIS | positive regulation of neuron apoptotic process | 13/1390 | 58/18723 | 2.65e-04 | 4.03e-03 | 13 |
| GO:003032413 | Breast | DCIS | lung development | 27/1390 | 177/18723 | 2.73e-04 | 4.09e-03 | 27 |
| GO:005110022 | Breast | DCIS | negative regulation of binding | 25/1390 | 162/18723 | 3.77e-04 | 5.27e-03 | 25 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
| hsa0421013 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
| hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
| hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
| hsa0421041 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
| hsa0421051 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
| hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
| hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
| hsa0421042 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
| hsa0421052 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
| hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
| hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
| hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
| hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
| hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
| hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
| hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
| hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
| hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
| hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
| Page: 1 2 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CTSZ | SNV | Missense_Mutation | c.731C>T | p.Ser244Phe | p.S244F | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| CTSZ | SNV | Missense_Mutation | c.867C>G | p.Asn289Lys | p.N289K | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
| CTSZ | SNV | Missense_Mutation | c.785N>T | p.Ser262Leu | p.S262L | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| CTSZ | SNV | Missense_Mutation | novel | c.668N>G | p.Ala223Gly | p.A223G | Q9UBR2 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| CTSZ | SNV | Missense_Mutation | rs748740856 | c.418N>A | p.Val140Met | p.V140M | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| CTSZ | SNV | Missense_Mutation | novel | c.718N>C | p.Asn240His | p.N240H | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
| CTSZ | SNV | Missense_Mutation | rs202127342 | c.580N>A | p.Gly194Ser | p.G194S | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| CTSZ | SNV | Missense_Mutation | rs368797360 | c.880N>A | p.Glu294Lys | p.E294K | Q9UBR2 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 1522 | CTSZ | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103092 | ODANACATIB |
| Page: 1 |
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