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Gene: CREB3L2 |
Gene summary for CREB3L2 |
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Gene information | Species | Human | Gene symbol | CREB3L2 | Gene ID | 64764 |
Gene name | cAMP responsive element binding protein 3 like 2 | |
Gene Alias | BBF2H7 | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q70SY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64764 | CREB3L2 | LZE4T | Human | Esophagus | ESCC | 1.63e-06 | 1.47e-01 | 0.0811 |
64764 | CREB3L2 | LZE20T | Human | Esophagus | ESCC | 1.02e-03 | 8.32e-02 | 0.0662 |
64764 | CREB3L2 | LZE24T | Human | Esophagus | ESCC | 2.21e-07 | 4.97e-02 | 0.0596 |
64764 | CREB3L2 | P1T-E | Human | Esophagus | ESCC | 1.48e-02 | 4.41e-01 | 0.0875 |
64764 | CREB3L2 | P2T-E | Human | Esophagus | ESCC | 1.12e-06 | 9.49e-02 | 0.1177 |
64764 | CREB3L2 | P4T-E | Human | Esophagus | ESCC | 2.96e-24 | 3.07e-01 | 0.1323 |
64764 | CREB3L2 | P5T-E | Human | Esophagus | ESCC | 7.77e-15 | 1.44e-01 | 0.1327 |
64764 | CREB3L2 | P8T-E | Human | Esophagus | ESCC | 7.58e-11 | 3.54e-01 | 0.0889 |
64764 | CREB3L2 | P9T-E | Human | Esophagus | ESCC | 4.48e-09 | 9.44e-02 | 0.1131 |
64764 | CREB3L2 | P10T-E | Human | Esophagus | ESCC | 1.10e-12 | 2.11e-01 | 0.116 |
64764 | CREB3L2 | P11T-E | Human | Esophagus | ESCC | 3.35e-11 | 5.27e-01 | 0.1426 |
64764 | CREB3L2 | P12T-E | Human | Esophagus | ESCC | 1.26e-28 | 5.93e-01 | 0.1122 |
64764 | CREB3L2 | P15T-E | Human | Esophagus | ESCC | 6.06e-17 | 2.47e-01 | 0.1149 |
64764 | CREB3L2 | P16T-E | Human | Esophagus | ESCC | 1.26e-09 | 1.35e-01 | 0.1153 |
64764 | CREB3L2 | P19T-E | Human | Esophagus | ESCC | 1.65e-10 | 7.21e-01 | 0.1662 |
64764 | CREB3L2 | P20T-E | Human | Esophagus | ESCC | 2.19e-02 | 1.32e-02 | 0.1124 |
64764 | CREB3L2 | P21T-E | Human | Esophagus | ESCC | 1.95e-11 | 2.20e-01 | 0.1617 |
64764 | CREB3L2 | P22T-E | Human | Esophagus | ESCC | 3.34e-14 | 1.92e-01 | 0.1236 |
64764 | CREB3L2 | P23T-E | Human | Esophagus | ESCC | 3.71e-10 | 3.42e-01 | 0.108 |
64764 | CREB3L2 | P24T-E | Human | Esophagus | ESCC | 5.46e-09 | 1.50e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003096811 | Liver | HCC | endoplasmic reticulum unfolded protein response | 56/7958 | 74/18723 | 6.47e-09 | 1.67e-07 | 56 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:0010976 | Liver | HCC | positive regulation of neuron projection development | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:00109756 | Lung | IAC | regulation of neuron projection development | 82/2061 | 445/18723 | 1.82e-06 | 8.78e-05 | 82 |
GO:00313466 | Lung | IAC | positive regulation of cell projection organization | 63/2061 | 353/18723 | 7.37e-05 | 1.55e-03 | 63 |
GO:00349768 | Lung | IAC | response to endoplasmic reticulum stress | 46/2061 | 256/18723 | 5.58e-04 | 7.76e-03 | 46 |
GO:00359668 | Lung | IAC | response to topologically incorrect protein | 31/2061 | 159/18723 | 1.10e-03 | 1.29e-02 | 31 |
GO:00359678 | Lung | IAC | cellular response to topologically incorrect protein | 24/2061 | 116/18723 | 1.66e-03 | 1.74e-02 | 24 |
GO:00069868 | Lung | IAC | response to unfolded protein | 27/2061 | 137/18723 | 1.88e-03 | 1.92e-02 | 27 |
GO:00481937 | Lung | IAC | Golgi vesicle transport | 49/2061 | 296/18723 | 2.35e-03 | 2.28e-02 | 49 |
GO:00346208 | Lung | IAC | cellular response to unfolded protein | 20/2061 | 96/18723 | 3.58e-03 | 3.00e-02 | 20 |
GO:00109761 | Lung | IAC | positive regulation of neuron projection development | 29/2061 | 163/18723 | 6.20e-03 | 4.47e-02 | 29 |
GO:001097512 | Lung | AIS | regulation of neuron projection development | 69/1849 | 445/18723 | 1.05e-04 | 2.53e-03 | 69 |
GO:003134612 | Lung | AIS | positive regulation of cell projection organization | 57/1849 | 353/18723 | 1.38e-04 | 3.05e-03 | 57 |
GO:003497613 | Lung | AIS | response to endoplasmic reticulum stress | 42/1849 | 256/18723 | 7.09e-04 | 1.04e-02 | 42 |
GO:004819312 | Lung | AIS | Golgi vesicle transport | 46/1849 | 296/18723 | 1.32e-03 | 1.64e-02 | 46 |
GO:003596613 | Lung | AIS | response to topologically incorrect protein | 28/1849 | 159/18723 | 1.79e-03 | 2.02e-02 | 28 |
GO:000698613 | Lung | AIS | response to unfolded protein | 24/1849 | 137/18723 | 3.91e-03 | 3.59e-02 | 24 |
GO:003596713 | Lung | AIS | cellular response to topologically incorrect protein | 21/1849 | 116/18723 | 4.52e-03 | 4.00e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa05020210 | Esophagus | ESCC | Prion disease | 193/4205 | 273/8465 | 6.42e-13 | 1.34e-11 | 6.89e-12 | 193 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa05163210 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0521516 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa051619 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0496223 | Esophagus | ESCC | Vasopressin-regulated water reabsorption | 33/4205 | 44/8465 | 5.27e-04 | 1.78e-03 | 9.13e-04 | 33 |
hsa049268 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa049318 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0421114 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CREB3L2 | SNV | Missense_Mutation | c.375C>G | p.Ile125Met | p.I125M | Q70SY1 | protein_coding | tolerated(0.11) | possibly_damaging(0.797) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
CREB3L2 | SNV | Missense_Mutation | rs754799812 | c.269G>A | p.Arg90Gln | p.R90Q | Q70SY1 | protein_coding | tolerated(0.05) | benign(0.183) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CREB3L2 | SNV | Missense_Mutation | c.1315N>A | p.Glu439Lys | p.E439K | Q70SY1 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CREB3L2 | SNV | Missense_Mutation | rs778038461 | c.419C>T | p.Pro140Leu | p.P140L | Q70SY1 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREB3L2 | SNV | Missense_Mutation | c.1455N>T | p.Glu485Asp | p.E485D | Q70SY1 | protein_coding | tolerated(0.17) | benign(0.164) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CREB3L2 | SNV | Missense_Mutation | c.1418T>C | p.Leu473Pro | p.L473P | Q70SY1 | protein_coding | tolerated(0.28) | possibly_damaging(0.491) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CREB3L2 | SNV | Missense_Mutation | novel | c.938G>T | p.Arg313Ile | p.R313I | Q70SY1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CREB3L2 | insertion | Nonsense_Mutation | novel | c.1441_1442insTATTTGAGAATTTGGCTACTTGCTGATATTTATTTGTCACCCTA | p.Glu481ValfsTer9 | p.E481Vfs*9 | Q70SY1 | protein_coding | TCGA-F5-6465-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CREB3L2 | SNV | Missense_Mutation | c.1455G>T | p.Glu485Asp | p.E485D | Q70SY1 | protein_coding | tolerated(0.17) | benign(0.164) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CREB3L2 | SNV | Missense_Mutation | novel | c.958G>A | p.Asp320Asn | p.D320N | Q70SY1 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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