![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: COX14 |
Gene summary for COX14 |
![]() |
Gene information | Species | Human | Gene symbol | COX14 | Gene ID | 84987 |
Gene name | cytochrome c oxidase assembly factor COX14 | |
Gene Alias | C12orf62 | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96I36 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84987 | COX14 | CA_HPV_1 | Human | Cervix | CC | 8.95e-04 | -5.77e-02 | 0.0264 |
84987 | COX14 | CCI_1 | Human | Cervix | CC | 3.85e-08 | -5.39e-01 | 0.528 |
84987 | COX14 | CCI_2 | Human | Cervix | CC | 2.08e-07 | -5.39e-01 | 0.5249 |
84987 | COX14 | CCI_3 | Human | Cervix | CC | 1.69e-08 | -5.24e-01 | 0.516 |
84987 | COX14 | CCII_1 | Human | Cervix | CC | 1.35e-15 | -5.39e-01 | 0.3249 |
84987 | COX14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.55e-09 | 2.03e-01 | 0.0155 |
84987 | COX14 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.31e-21 | 4.98e-01 | -0.1808 |
84987 | COX14 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.52e-01 | 0.0216 |
84987 | COX14 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-19 | 5.08e-01 | -0.0811 |
84987 | COX14 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.20e-05 | 1.68e-01 | -0.1088 |
84987 | COX14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.94e-23 | 4.34e-01 | -0.1954 |
84987 | COX14 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 6.61e-01 | -0.2602 |
84987 | COX14 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 2.76e-01 | -0.2196 |
84987 | COX14 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.67e-12 | 3.89e-01 | -0.1207 |
84987 | COX14 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.45e-18 | 6.36e-01 | -0.1526 |
84987 | COX14 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.45e-30 | 5.20e-01 | -0.1464 |
84987 | COX14 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.75e-18 | 4.22e-01 | -0.1001 |
84987 | COX14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.57e-29 | 7.02e-01 | -0.059 |
84987 | COX14 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.54e-11 | 4.65e-01 | -0.1706 |
84987 | COX14 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.21e-08 | 4.02e-01 | -0.2061 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
GO:00085351 | Liver | HCC | respiratory chain complex IV assembly | 22/7958 | 26/18723 | 1.23e-05 | 1.39e-04 | 22 |
GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
GO:00170043 | Oral cavity | OSCC | cytochrome complex assembly | 31/7305 | 36/18723 | 7.28e-09 | 1.53e-07 | 31 |
GO:00336172 | Oral cavity | OSCC | mitochondrial cytochrome c oxidase assembly | 19/7305 | 22/18723 | 6.52e-06 | 7.21e-05 | 19 |
GO:00085352 | Oral cavity | OSCC | respiratory chain complex IV assembly | 21/7305 | 26/18723 | 1.66e-05 | 1.64e-04 | 21 |
GO:003310819 | Oral cavity | LP | mitochondrial respiratory chain complex assembly | 63/4623 | 93/18723 | 2.24e-18 | 4.13e-16 | 63 |
GO:001700412 | Oral cavity | LP | cytochrome complex assembly | 25/4623 | 36/18723 | 1.93e-08 | 7.11e-07 | 25 |
GO:003361711 | Oral cavity | LP | mitochondrial cytochrome c oxidase assembly | 17/4623 | 22/18723 | 3.24e-07 | 9.53e-06 | 17 |
GO:000853511 | Oral cavity | LP | respiratory chain complex IV assembly | 18/4623 | 26/18723 | 2.13e-06 | 4.81e-05 | 18 |
GO:003310816 | Prostate | BPH | mitochondrial respiratory chain complex assembly | 45/3107 | 93/18723 | 1.08e-12 | 9.32e-11 | 45 |
GO:00170042 | Prostate | BPH | cytochrome complex assembly | 13/3107 | 36/18723 | 3.71e-03 | 1.87e-02 | 13 |
GO:003310817 | Prostate | Tumor | mitochondrial respiratory chain complex assembly | 47/3246 | 93/18723 | 2.28e-13 | 2.49e-11 | 47 |
GO:001700411 | Prostate | Tumor | cytochrome complex assembly | 14/3246 | 36/18723 | 1.79e-03 | 1.05e-02 | 14 |
GO:003310824 | Skin | cSCC | mitochondrial respiratory chain complex assembly | 64/4864 | 93/18723 | 5.48e-18 | 6.58e-16 | 64 |
GO:00170045 | Skin | cSCC | cytochrome complex assembly | 22/4864 | 36/18723 | 9.20e-06 | 1.21e-04 | 22 |
GO:00336174 | Skin | cSCC | mitochondrial cytochrome c oxidase assembly | 15/4864 | 22/18723 | 4.00e-05 | 4.27e-04 | 15 |
GO:00085354 | Skin | cSCC | respiratory chain complex IV assembly | 16/4864 | 26/18723 | 1.39e-04 | 1.26e-03 | 16 |
GO:003310825 | Thyroid | HT | mitochondrial respiratory chain complex assembly | 24/1272 | 93/18723 | 8.72e-09 | 7.58e-07 | 24 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa047144 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
hsa047145 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
hsa047146 | Colorectum | MSI-H | Thermogenesis | 56/797 | 232/8465 | 1.79e-11 | 4.14e-10 | 3.47e-10 | 56 |
hsa047147 | Colorectum | MSI-H | Thermogenesis | 56/797 | 232/8465 | 1.79e-11 | 4.14e-10 | 3.47e-10 | 56 |
hsa0471426 | Endometrium | AEH | Thermogenesis | 85/1197 | 232/8465 | 3.44e-18 | 9.33e-17 | 6.83e-17 | 85 |
hsa04714111 | Endometrium | AEH | Thermogenesis | 85/1197 | 232/8465 | 3.44e-18 | 9.33e-17 | 6.83e-17 | 85 |
hsa0471427 | Endometrium | EEC | Thermogenesis | 85/1237 | 232/8465 | 2.79e-17 | 7.05e-16 | 5.26e-16 | 85 |
hsa0471436 | Endometrium | EEC | Thermogenesis | 85/1237 | 232/8465 | 2.79e-17 | 7.05e-16 | 5.26e-16 | 85 |
hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471414 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0471415 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COX14 | SNV | Missense_Mutation | rs368516862 | c.98N>A | p.Arg33Gln | p.R33Q | Q96I36 | protein_coding | tolerated(0.07) | possibly_damaging(0.572) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |