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Gene: COMMD1 |
Gene summary for COMMD1 |
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Gene information | Species | Human | Gene symbol | COMMD1 | Gene ID | 150684 |
Gene name | copper metabolism domain containing 1 | |
Gene Alias | C2orf5 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | Q8N668 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150684 | COMMD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.03e-13 | -4.62e-01 | 0.0155 |
150684 | COMMD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.84e-05 | -3.14e-01 | 0.096 |
150684 | COMMD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.11e-17 | -4.48e-01 | 0.294 |
150684 | COMMD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.14e-03 | -3.58e-01 | 0.3859 |
150684 | COMMD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.08e-03 | -2.96e-01 | 0.3005 |
150684 | COMMD1 | A015-C-203 | Human | Colorectum | FAP | 8.44e-20 | -4.72e-01 | -0.1294 |
150684 | COMMD1 | A015-C-204 | Human | Colorectum | FAP | 4.34e-04 | -3.33e-01 | -0.0228 |
150684 | COMMD1 | A014-C-040 | Human | Colorectum | FAP | 9.11e-03 | -4.10e-01 | -0.1184 |
150684 | COMMD1 | A002-C-201 | Human | Colorectum | FAP | 3.39e-13 | -4.23e-01 | 0.0324 |
150684 | COMMD1 | A001-C-119 | Human | Colorectum | FAP | 1.87e-06 | -4.05e-01 | -0.1557 |
150684 | COMMD1 | A001-C-108 | Human | Colorectum | FAP | 3.91e-13 | -3.31e-01 | -0.0272 |
150684 | COMMD1 | A002-C-205 | Human | Colorectum | FAP | 1.18e-20 | -5.10e-01 | -0.1236 |
150684 | COMMD1 | A015-C-006 | Human | Colorectum | FAP | 3.97e-11 | -4.14e-01 | -0.0994 |
150684 | COMMD1 | A015-C-106 | Human | Colorectum | FAP | 6.34e-11 | -2.66e-01 | -0.0511 |
150684 | COMMD1 | A002-C-114 | Human | Colorectum | FAP | 2.64e-13 | -4.28e-01 | -0.1561 |
150684 | COMMD1 | A015-C-104 | Human | Colorectum | FAP | 7.50e-21 | -4.95e-01 | -0.1899 |
150684 | COMMD1 | A001-C-014 | Human | Colorectum | FAP | 4.93e-12 | -3.83e-01 | 0.0135 |
150684 | COMMD1 | A002-C-016 | Human | Colorectum | FAP | 7.13e-16 | -3.72e-01 | 0.0521 |
150684 | COMMD1 | A015-C-002 | Human | Colorectum | FAP | 1.84e-10 | -5.21e-01 | -0.0763 |
150684 | COMMD1 | A001-C-203 | Human | Colorectum | FAP | 7.20e-05 | -1.73e-01 | -0.0481 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421762 | Colorectum | MSS | regulation of protein catabolic process | 145/3467 | 391/18723 | 2.03e-18 | 1.17e-15 | 145 |
GO:19033622 | Colorectum | MSS | regulation of cellular protein catabolic process | 99/3467 | 255/18723 | 1.90e-14 | 5.37e-12 | 99 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:19030502 | Colorectum | MSS | regulation of proteolysis involved in cellular protein catabolic process | 82/3467 | 221/18723 | 4.97e-11 | 5.64e-09 | 82 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00988762 | Colorectum | MSS | vesicle-mediated transport to the plasma membrane | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:19033202 | Colorectum | MSS | regulation of protein modification by small protein conjugation or removal | 82/3467 | 242/18723 | 7.49e-09 | 4.63e-07 | 82 |
GO:20000582 | Colorectum | MSS | regulation of ubiquitin-dependent protein catabolic process | 61/3467 | 164/18723 | 1.28e-08 | 7.61e-07 | 61 |
GO:00611362 | Colorectum | MSS | regulation of proteasomal protein catabolic process | 67/3467 | 187/18723 | 1.45e-08 | 8.47e-07 | 67 |
GO:00313962 | Colorectum | MSS | regulation of protein ubiquitination | 70/3467 | 210/18723 | 1.88e-07 | 8.26e-06 | 70 |
GO:00324342 | Colorectum | MSS | regulation of proteasomal ubiquitin-dependent protein catabolic process | 49/3467 | 134/18723 | 6.02e-07 | 2.26e-05 | 49 |
GO:00068922 | Colorectum | MSS | post-Golgi vesicle-mediated transport | 40/3467 | 104/18723 | 1.45e-06 | 4.82e-05 | 40 |
GO:00068931 | Colorectum | MSS | Golgi to plasma membrane transport | 26/3467 | 60/18723 | 8.01e-06 | 2.03e-04 | 26 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00020282 | Colorectum | MSS | regulation of sodium ion transport | 32/3467 | 90/18723 | 9.56e-05 | 1.50e-03 | 32 |
GO:19023052 | Colorectum | MSS | regulation of sodium ion transmembrane transport | 26/3467 | 68/18723 | 1.08e-04 | 1.68e-03 | 26 |
GO:19038282 | Colorectum | MSS | negative regulation of cellular protein localization | 36/3467 | 117/18723 | 9.19e-04 | 9.34e-03 | 36 |
GO:0051090 | Colorectum | MSS | regulation of DNA-binding transcription factor activity | 106/3467 | 440/18723 | 1.88e-03 | 1.65e-02 | 106 |
GO:20000092 | Colorectum | MSS | negative regulation of protein localization to cell surface | 7/3467 | 12/18723 | 2.45e-03 | 1.97e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COMMD1 | SNV | Missense_Mutation | c.409N>G | p.Gln137Glu | p.Q137E | Q8N668 | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
COMMD1 | SNV | Missense_Mutation | novel | c.443A>G | p.Glu148Gly | p.E148G | Q8N668 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COMMD1 | SNV | Missense_Mutation | rs779213025 | c.340N>T | p.Arg114Cys | p.R114C | Q8N668 | protein_coding | tolerated(0.14) | benign(0.041) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
COMMD1 | SNV | Missense_Mutation | novel | c.157N>A | p.Ala53Thr | p.A53T | Q8N668 | protein_coding | tolerated(0.43) | benign(0.187) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COMMD1 | SNV | Missense_Mutation | novel | c.88A>G | p.Ile30Val | p.I30V | Q8N668 | protein_coding | tolerated(0.25) | benign(0.006) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
COMMD1 | SNV | Missense_Mutation | novel | c.353G>C | p.Gly118Ala | p.G118A | Q8N668 | protein_coding | tolerated(0.8) | benign(0.02) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
COMMD1 | SNV | Missense_Mutation | novel | c.508N>A | p.Gln170Lys | p.Q170K | Q8N668 | protein_coding | tolerated(0.14) | benign(0.294) | TCGA-63-A5MW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COMMD1 | SNV | Missense_Mutation | c.433N>G | p.Ile145Val | p.I145V | Q8N668 | protein_coding | tolerated(1) | benign(0) | TCGA-66-2771-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
COMMD1 | SNV | Missense_Mutation | c.425N>C | p.Val142Ala | p.V142A | Q8N668 | protein_coding | tolerated(0.07) | benign(0.318) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
COMMD1 | insertion | Nonsense_Mutation | novel | c.260_261insTTGAGGTT | p.Ser88Ter | p.S88* | Q8N668 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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