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Gene: CLPTM1 |
Gene summary for CLPTM1 |
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Gene information | Species | Human | Gene symbol | CLPTM1 | Gene ID | 1209 |
Gene name | CLPTM1 regulator of GABA type A receptor forward trafficking | |
Gene Alias | CLPTM1 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | O96005 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1209 | CLPTM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.81e-02 | 1.72e-01 | 0.0155 |
1209 | CLPTM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.88e-08 | 5.07e-01 | -0.1808 |
1209 | CLPTM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.90e-03 | 4.20e-01 | -0.0811 |
1209 | CLPTM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.56e-08 | 4.60e-01 | -0.1954 |
1209 | CLPTM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.20e-03 | 4.58e-01 | -0.1526 |
1209 | CLPTM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-16 | 5.90e-01 | -0.1464 |
1209 | CLPTM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.76e-06 | 2.97e-01 | -0.1001 |
1209 | CLPTM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.26e-13 | 6.30e-01 | -0.059 |
1209 | CLPTM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.48e-04 | 5.48e-01 | -0.0842 |
1209 | CLPTM1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.85e-02 | 3.44e-01 | 0.0338 |
1209 | CLPTM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.13e-24 | 6.59e-01 | 0.0674 |
1209 | CLPTM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.26e-08 | 3.92e-01 | 0.3859 |
1209 | CLPTM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.61e-02 | 2.75e-01 | 0.3005 |
1209 | CLPTM1 | A002-C-201 | Human | Colorectum | FAP | 3.68e-02 | -1.31e-01 | 0.0324 |
1209 | CLPTM1 | A002-C-116 | Human | Colorectum | FAP | 9.36e-06 | -1.24e-01 | -0.0452 |
1209 | CLPTM1 | LZE2T | Human | Esophagus | ESCC | 3.39e-04 | 9.01e-01 | 0.082 |
1209 | CLPTM1 | LZE4T | Human | Esophagus | ESCC | 5.05e-06 | 3.25e-01 | 0.0811 |
1209 | CLPTM1 | LZE5T | Human | Esophagus | ESCC | 1.66e-05 | 4.06e-01 | 0.0514 |
1209 | CLPTM1 | LZE7T | Human | Esophagus | ESCC | 2.89e-03 | 3.73e-01 | 0.0667 |
1209 | CLPTM1 | LZE8T | Human | Esophagus | ESCC | 7.60e-07 | 6.78e-02 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004211017 | Oral cavity | LP | T cell activation | 146/4623 | 487/18723 | 4.13e-03 | 2.66e-02 | 146 |
GO:190370619 | Oral cavity | LP | regulation of hemopoiesis | 111/4623 | 367/18723 | 8.48e-03 | 4.60e-02 | 111 |
GO:190370626 | Skin | cSCC | regulation of hemopoiesis | 120/4864 | 367/18723 | 2.23e-03 | 1.32e-02 | 120 |
GO:190210524 | Skin | cSCC | regulation of leukocyte differentiation | 92/4864 | 279/18723 | 5.20e-03 | 2.63e-02 | 92 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLPTM1 | SNV | Missense_Mutation | c.921N>G | p.Phe307Leu | p.F307L | O96005 | protein_coding | tolerated(0.05) | benign(0.026) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CLPTM1 | SNV | Missense_Mutation | rs199925354 | c.886N>A | p.Glu296Lys | p.E296K | O96005 | protein_coding | tolerated(0.08) | benign(0.148) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CLPTM1 | insertion | Nonsense_Mutation | novel | c.182_183insAGGACAGCAAAAGACTCTCTAGGTCACCACTGTCCC | p.Phe61delinsLeuGlyGlnGlnLysThrLeuTerValThrThrValPro | p.F61delinsLGQQKTL*VTTVP | O96005 | protein_coding | TCGA-BH-A0B3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
CLPTM1 | deletion | Frame_Shift_Del | novel | c.829delN | p.Ile278SerfsTer68 | p.I278Sfs*68 | O96005 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CLPTM1 | SNV | Missense_Mutation | novel | c.152N>C | p.Asn51Thr | p.N51T | O96005 | protein_coding | deleterious(0.02) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLPTM1 | SNV | Missense_Mutation | novel | c.1579N>T | p.Leu527Phe | p.L527F | O96005 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLPTM1 | SNV | Missense_Mutation | novel | c.114N>C | p.Glu38Asp | p.E38D | O96005 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CLPTM1 | SNV | Missense_Mutation | novel | c.1137C>G | p.Ile379Met | p.I379M | O96005 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CLPTM1 | SNV | Missense_Mutation | c.656N>G | p.Asp219Gly | p.D219G | O96005 | protein_coding | tolerated(0.17) | benign(0.03) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CLPTM1 | SNV | Missense_Mutation | rs770360744 | c.1198N>A | p.Val400Ile | p.V400I | O96005 | protein_coding | tolerated(0.2) | possibly_damaging(0.457) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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