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Gene: CLEC7A |
Gene summary for CLEC7A |
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Gene information | Species | Human | Gene symbol | CLEC7A | Gene ID | 64581 |
Gene name | C-type lectin domain containing 7A | |
Gene Alias | BGR | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q68D78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64581 | CLEC7A | P1T-E | Human | Esophagus | ESCC | 6.11e-03 | 1.28e-01 | 0.0875 |
64581 | CLEC7A | P4T-E | Human | Esophagus | ESCC | 3.02e-03 | 2.23e-01 | 0.1323 |
64581 | CLEC7A | P20T-E | Human | Esophagus | ESCC | 9.46e-06 | 7.73e-02 | 0.1124 |
64581 | CLEC7A | P22T-E | Human | Esophagus | ESCC | 4.60e-53 | 1.30e+00 | 0.1236 |
64581 | CLEC7A | P23T-E | Human | Esophagus | ESCC | 3.86e-05 | 3.25e-01 | 0.108 |
64581 | CLEC7A | P24T-E | Human | Esophagus | ESCC | 1.14e-02 | 2.64e-01 | 0.1287 |
64581 | CLEC7A | P31T-E | Human | Esophagus | ESCC | 2.17e-10 | 2.59e-01 | 0.1251 |
64581 | CLEC7A | P40T-E | Human | Esophagus | ESCC | 7.29e-06 | 3.33e-01 | 0.109 |
64581 | CLEC7A | P42T-E | Human | Esophagus | ESCC | 4.81e-02 | 2.86e-01 | 0.1175 |
64581 | CLEC7A | P61T-E | Human | Esophagus | ESCC | 8.51e-03 | 1.16e-02 | 0.099 |
64581 | CLEC7A | P62T-E | Human | Esophagus | ESCC | 3.09e-27 | 7.61e-01 | 0.1302 |
64581 | CLEC7A | P65T-E | Human | Esophagus | ESCC | 4.46e-06 | 1.57e-01 | 0.0978 |
64581 | CLEC7A | P80T-E | Human | Esophagus | ESCC | 3.23e-08 | 5.53e-01 | 0.155 |
64581 | CLEC7A | P107T-E | Human | Esophagus | ESCC | 1.87e-25 | 8.29e-01 | 0.171 |
64581 | CLEC7A | P126T-E | Human | Esophagus | ESCC | 1.51e-02 | 4.51e-01 | 0.1125 |
64581 | CLEC7A | P127T-E | Human | Esophagus | ESCC | 1.69e-06 | 1.47e-01 | 0.0826 |
64581 | CLEC7A | P130T-E | Human | Esophagus | ESCC | 2.89e-57 | 1.24e+00 | 0.1676 |
64581 | CLEC7A | C04 | Human | Oral cavity | OSCC | 6.79e-09 | 5.67e-01 | 0.2633 |
64581 | CLEC7A | C30 | Human | Oral cavity | OSCC | 2.16e-12 | 8.04e-01 | 0.3055 |
64581 | CLEC7A | C38 | Human | Oral cavity | OSCC | 3.06e-04 | 7.83e-01 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001056110 | Esophagus | ESCC | positive regulation of cysteine-type endopeptidase activity | 94/8552 | 148/18723 | 8.87e-06 | 8.59e-05 | 94 |
GO:007030217 | Esophagus | ESCC | regulation of stress-activated protein kinase signaling cascade | 119/8552 | 195/18723 | 1.07e-05 | 1.01e-04 | 119 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:003287217 | Esophagus | ESCC | regulation of stress-activated MAPK cascade | 116/8552 | 192/18723 | 2.63e-05 | 2.21e-04 | 116 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:00510926 | Esophagus | ESCC | positive regulation of NF-kappaB transcription factor activity | 91/8552 | 152/18723 | 2.91e-04 | 1.75e-03 | 91 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:003582114 | Esophagus | ESCC | modulation of process of other organism | 64/8552 | 106/18723 | 1.61e-03 | 7.50e-03 | 64 |
GO:00507303 | Esophagus | ESCC | regulation of peptidyl-tyrosine phosphorylation | 144/8552 | 264/18723 | 2.22e-03 | 9.78e-03 | 144 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:000680917 | Esophagus | ESCC | nitric oxide biosynthetic process | 47/8552 | 76/18723 | 3.29e-03 | 1.35e-02 | 47 |
GO:200105717 | Esophagus | ESCC | reactive nitrogen species metabolic process | 50/8552 | 82/18723 | 3.76e-03 | 1.53e-02 | 50 |
GO:00703046 | Esophagus | ESCC | positive regulation of stress-activated protein kinase signaling cascade | 74/8552 | 128/18723 | 3.77e-03 | 1.53e-02 | 74 |
GO:004620917 | Esophagus | ESCC | nitric oxide metabolic process | 49/8552 | 81/18723 | 5.11e-03 | 1.93e-02 | 49 |
GO:190303420 | Esophagus | ESCC | regulation of response to wounding | 93/8552 | 167/18723 | 5.77e-03 | 2.14e-02 | 93 |
GO:00328745 | Esophagus | ESCC | positive regulation of stress-activated MAPK cascade | 72/8552 | 126/18723 | 6.24e-03 | 2.29e-02 | 72 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046259 | Esophagus | ESCC | C-type lectin receptor signaling pathway | 73/4205 | 104/8465 | 1.57e-05 | 7.98e-05 | 4.09e-05 | 73 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa0462513 | Esophagus | ESCC | C-type lectin receptor signaling pathway | 73/4205 | 104/8465 | 1.57e-05 | 7.98e-05 | 4.09e-05 | 73 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0515212 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa046258 | Oral cavity | OSCC | C-type lectin receptor signaling pathway | 73/3704 | 104/8465 | 3.83e-08 | 3.12e-07 | 1.59e-07 | 73 |
hsa051526 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa0414528 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0462512 | Oral cavity | OSCC | C-type lectin receptor signaling pathway | 73/3704 | 104/8465 | 3.83e-08 | 3.12e-07 | 1.59e-07 | 73 |
hsa0515211 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa04145113 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0414529 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0462521 | Oral cavity | LP | C-type lectin receptor signaling pathway | 43/2418 | 104/8465 | 3.33e-03 | 1.41e-02 | 9.06e-03 | 43 |
hsa0515221 | Oral cavity | LP | Tuberculosis | 65/2418 | 180/8465 | 1.60e-02 | 4.92e-02 | 3.17e-02 | 65 |
hsa0414536 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0462531 | Oral cavity | LP | C-type lectin receptor signaling pathway | 43/2418 | 104/8465 | 3.33e-03 | 1.41e-02 | 9.06e-03 | 43 |
hsa0515231 | Oral cavity | LP | Tuberculosis | 65/2418 | 180/8465 | 1.60e-02 | 4.92e-02 | 3.17e-02 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLEC7A | SNV | Missense_Mutation | novel | c.433N>C | p.Lys145Gln | p.K145Q | Q9BXN2 | protein_coding | tolerated(0.22) | possibly_damaging(0.886) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
CLEC7A | SNV | Missense_Mutation | novel | c.480N>A | p.Ser160Arg | p.S160R | Q9BXN2 | protein_coding | deleterious(0) | possibly_damaging(0.529) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLEC7A | SNV | Missense_Mutation | c.85N>A | p.Ala29Thr | p.A29T | Q9BXN2 | protein_coding | tolerated(0.12) | benign(0.024) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLEC7A | SNV | Missense_Mutation | c.625N>G | p.Thr209Ala | p.T209A | Q9BXN2 | protein_coding | tolerated(0.1) | benign(0.079) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLEC7A | SNV | Missense_Mutation | novel | c.5N>C | p.Glu2Ala | p.E2A | Q9BXN2 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLEC7A | SNV | Missense_Mutation | novel | c.196A>G | p.Thr66Ala | p.T66A | Q9BXN2 | protein_coding | tolerated(0.42) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CLEC7A | SNV | Missense_Mutation | rs759032825 | c.65C>T | p.Ser22Phe | p.S22F | Q9BXN2 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLEC7A | SNV | Missense_Mutation | novel | c.729N>T | p.Lys243Asn | p.K243N | Q9BXN2 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLEC7A | SNV | Missense_Mutation | novel | c.209N>T | p.Trp70Leu | p.W70L | Q9BXN2 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLEC7A | SNV | Missense_Mutation | c.26A>G | p.Asn9Ser | p.N9S | Q9BXN2 | protein_coding | deleterious(0.02) | benign(0.217) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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