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Gene: CERT1 |
Gene summary for CERT1 |
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Gene information | Species | Human | Gene symbol | CERT1 | Gene ID | 10087 |
Gene name | ceramide transporter 1 | |
Gene Alias | CERT | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y5P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10087 | CERT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-09 | 2.13e-01 | 0.0155 |
10087 | CERT1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 2.75e-01 | -0.1808 |
10087 | CERT1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 2.22e-01 | 0.0216 |
10087 | CERT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-19 | 5.72e-01 | -0.0811 |
10087 | CERT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.83e-27 | 6.13e-01 | -0.1088 |
10087 | CERT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.10e-46 | 8.26e-01 | -0.1954 |
10087 | CERT1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 6.00e-01 | -0.2602 |
10087 | CERT1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 3.07e-01 | -0.2196 |
10087 | CERT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.57e-07 | 2.99e-01 | -0.1207 |
10087 | CERT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.13e-10 | 3.34e-01 | -0.1526 |
10087 | CERT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.63e-19 | 3.37e-01 | -0.1464 |
10087 | CERT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.02e-22 | 4.08e-01 | -0.1001 |
10087 | CERT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.20e-22 | 4.99e-01 | -0.059 |
10087 | CERT1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.10e-01 | -0.1706 |
10087 | CERT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.22e-01 | -0.2061 |
10087 | CERT1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.63e-01 | -0.1462 |
10087 | CERT1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 3.33e-01 | -0.0842 |
10087 | CERT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.51e-05 | 1.77e-01 | 0.096 |
10087 | CERT1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.13e-05 | 3.07e-01 | 0.0528 |
10087 | CERT1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.70e-11 | 5.64e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000301213 | Endometrium | EEC | muscle system process | 79/2168 | 452/18723 | 1.16e-04 | 1.55e-03 | 79 |
GO:00030071 | Endometrium | EEC | heart morphogenesis | 45/2168 | 246/18723 | 1.24e-03 | 1.03e-02 | 45 |
GO:00069361 | Endometrium | EEC | muscle contraction | 59/2168 | 347/18723 | 1.57e-03 | 1.26e-02 | 59 |
GO:00017016 | Lung | IAC | in utero embryonic development | 68/2061 | 367/18723 | 1.12e-05 | 3.45e-04 | 68 |
GO:00349768 | Lung | IAC | response to endoplasmic reticulum stress | 46/2061 | 256/18723 | 5.58e-04 | 7.76e-03 | 46 |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
GO:00159142 | Lung | IAC | phospholipid transport | 20/2061 | 96/18723 | 3.58e-03 | 3.00e-02 | 20 |
GO:00157482 | Lung | IAC | organophosphate ester transport | 26/2061 | 140/18723 | 5.22e-03 | 3.97e-02 | 26 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:003497613 | Lung | AIS | response to endoplasmic reticulum stress | 42/1849 | 256/18723 | 7.09e-04 | 1.04e-02 | 42 |
GO:000301211 | Lung | AIS | muscle system process | 63/1849 | 452/18723 | 3.18e-03 | 3.05e-02 | 63 |
GO:001591411 | Lung | AIS | phospholipid transport | 18/1849 | 96/18723 | 5.64e-03 | 4.76e-02 | 18 |
GO:000170131 | Lung | MIAC | in utero embryonic development | 33/967 | 367/18723 | 1.44e-03 | 2.54e-02 | 33 |
GO:000170120 | Skin | AK | in utero embryonic development | 75/1910 | 367/18723 | 3.09e-09 | 2.62e-07 | 75 |
GO:003497626 | Skin | AK | response to endoplasmic reticulum stress | 46/1910 | 256/18723 | 9.99e-05 | 1.33e-03 | 46 |
GO:00030129 | Skin | AK | muscle system process | 64/1910 | 452/18723 | 4.32e-03 | 2.52e-02 | 64 |
GO:01200094 | Skin | AK | intermembrane lipid transfer | 11/1910 | 48/18723 | 7.81e-03 | 3.96e-02 | 11 |
GO:0001701110 | Skin | SCCIS | in utero embryonic development | 32/919 | 367/18723 | 1.23e-03 | 1.45e-02 | 32 |
GO:0034976112 | Skin | cSCC | response to endoplasmic reticulum stress | 128/4864 | 256/18723 | 1.16e-16 | 1.17e-14 | 128 |
GO:000170124 | Skin | cSCC | in utero embryonic development | 150/4864 | 367/18723 | 2.47e-10 | 1.04e-08 | 150 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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