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Gene: CBLL1 |
Gene summary for CBLL1 |
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Gene information | Species | Human | Gene symbol | CBLL1 | Gene ID | 79872 |
Gene name | Cbl proto-oncogene like 1 | |
Gene Alias | HAKAI | |
Cytomap | 7q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q75N03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79872 | CBLL1 | LZE4T | Human | Esophagus | ESCC | 5.46e-09 | 1.43e-01 | 0.0811 |
79872 | CBLL1 | LZE8T | Human | Esophagus | ESCC | 1.31e-02 | 5.87e-02 | 0.067 |
79872 | CBLL1 | LZE20T | Human | Esophagus | ESCC | 4.44e-02 | 1.32e-01 | 0.0662 |
79872 | CBLL1 | LZE24T | Human | Esophagus | ESCC | 1.45e-15 | 2.65e-01 | 0.0596 |
79872 | CBLL1 | LZE6T | Human | Esophagus | ESCC | 5.37e-03 | 1.11e-01 | 0.0845 |
79872 | CBLL1 | P1T-E | Human | Esophagus | ESCC | 2.67e-07 | 1.87e-01 | 0.0875 |
79872 | CBLL1 | P2T-E | Human | Esophagus | ESCC | 5.68e-13 | 1.28e-01 | 0.1177 |
79872 | CBLL1 | P4T-E | Human | Esophagus | ESCC | 6.40e-07 | 2.43e-01 | 0.1323 |
79872 | CBLL1 | P5T-E | Human | Esophagus | ESCC | 1.96e-12 | 1.10e-01 | 0.1327 |
79872 | CBLL1 | P8T-E | Human | Esophagus | ESCC | 1.45e-14 | 1.59e-01 | 0.0889 |
79872 | CBLL1 | P9T-E | Human | Esophagus | ESCC | 5.11e-12 | 1.63e-01 | 0.1131 |
79872 | CBLL1 | P10T-E | Human | Esophagus | ESCC | 2.14e-19 | 2.08e-01 | 0.116 |
79872 | CBLL1 | P11T-E | Human | Esophagus | ESCC | 7.52e-04 | 3.82e-01 | 0.1426 |
79872 | CBLL1 | P12T-E | Human | Esophagus | ESCC | 3.10e-16 | 3.34e-01 | 0.1122 |
79872 | CBLL1 | P15T-E | Human | Esophagus | ESCC | 2.73e-19 | 4.48e-01 | 0.1149 |
79872 | CBLL1 | P16T-E | Human | Esophagus | ESCC | 2.20e-20 | 1.91e-01 | 0.1153 |
79872 | CBLL1 | P17T-E | Human | Esophagus | ESCC | 5.53e-04 | 5.49e-01 | 0.1278 |
79872 | CBLL1 | P20T-E | Human | Esophagus | ESCC | 3.27e-31 | 8.01e-01 | 0.1124 |
79872 | CBLL1 | P21T-E | Human | Esophagus | ESCC | 1.22e-16 | 2.46e-01 | 0.1617 |
79872 | CBLL1 | P22T-E | Human | Esophagus | ESCC | 9.82e-14 | 1.17e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003010010 | Prostate | BPH | regulation of endocytosis | 60/3107 | 211/18723 | 1.06e-05 | 1.45e-04 | 60 |
GO:00458079 | Prostate | BPH | positive regulation of endocytosis | 32/3107 | 100/18723 | 1.09e-04 | 9.95e-04 | 32 |
GO:000716215 | Prostate | Tumor | negative regulation of cell adhesion | 82/3246 | 303/18723 | 1.38e-05 | 1.89e-04 | 82 |
GO:003010015 | Prostate | Tumor | regulation of endocytosis | 60/3246 | 211/18723 | 4.05e-05 | 4.62e-04 | 60 |
GO:004580716 | Prostate | Tumor | positive regulation of endocytosis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBLL1 | SNV | Missense_Mutation | c.1145N>T | p.Pro382Leu | p.P382L | Q75N03 | protein_coding | tolerated(0.09) | probably_damaging(0.998) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
CBLL1 | SNV | Missense_Mutation | rs763554958 | c.403N>G | p.Ile135Val | p.I135V | Q75N03 | protein_coding | tolerated(0.7) | benign(0.015) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CBLL1 | SNV | Missense_Mutation | c.140C>A | p.Thr47Asn | p.T47N | Q75N03 | protein_coding | tolerated(0.21) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
CBLL1 | SNV | Missense_Mutation | c.655C>T | p.Arg219Cys | p.R219C | Q75N03 | protein_coding | tolerated(0.2) | possibly_damaging(0.872) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CBLL1 | SNV | Missense_Mutation | novel | c.1157C>A | p.Pro386His | p.P386H | Q75N03 | protein_coding | deleterious(0.01) | possibly_damaging(0.865) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CBLL1 | SNV | Missense_Mutation | c.202N>C | p.Glu68Gln | p.E68Q | Q75N03 | protein_coding | deleterious(0.01) | benign(0.294) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CBLL1 | SNV | Missense_Mutation | novel | c.566N>A | p.Arg189His | p.R189H | Q75N03 | protein_coding | tolerated(0.07) | probably_damaging(0.911) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | c.652N>C | p.Glu218Gln | p.E218Q | Q75N03 | protein_coding | deleterious(0.02) | benign(0.086) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CBLL1 | SNV | Missense_Mutation | c.1402N>T | p.Gly468Cys | p.G468C | Q75N03 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CBLL1 | SNV | Missense_Mutation | rs756843724 | c.74N>A | p.Arg25Gln | p.R25Q | Q75N03 | protein_coding | tolerated_low_confidence(0.21) | benign(0.061) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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