Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAMKK2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAMKK2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAMKK2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAMKK2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000989612 | Liver | Cirrhotic | positive regulation of catabolic process | 215/4634 | 492/18723 | 1.13e-20 | 3.56e-18 | 215 |
GO:003133112 | Liver | Cirrhotic | positive regulation of cellular catabolic process | 190/4634 | 427/18723 | 1.94e-19 | 4.18e-17 | 190 |
GO:000697912 | Liver | Cirrhotic | response to oxidative stress | 196/4634 | 446/18723 | 2.80e-19 | 5.86e-17 | 196 |
GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
GO:006219712 | Liver | Cirrhotic | cellular response to chemical stress | 147/4634 | 337/18723 | 1.84e-14 | 1.72e-12 | 147 |
GO:003459912 | Liver | Cirrhotic | cellular response to oxidative stress | 127/4634 | 288/18723 | 4.29e-13 | 3.32e-11 | 127 |
GO:001050611 | Liver | Cirrhotic | regulation of autophagy | 132/4634 | 317/18723 | 2.17e-11 | 1.33e-09 | 132 |
GO:000030212 | Liver | Cirrhotic | response to reactive oxygen species | 100/4634 | 222/18723 | 2.92e-11 | 1.73e-09 | 100 |
GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
GO:00346147 | Liver | Cirrhotic | cellular response to reactive oxygen species | 70/4634 | 155/18723 | 2.27e-08 | 7.91e-07 | 70 |
GO:00004225 | Liver | Cirrhotic | autophagy of mitochondrion | 43/4634 | 81/18723 | 4.02e-08 | 1.31e-06 | 43 |
GO:00617265 | Liver | Cirrhotic | mitochondrion disassembly | 43/4634 | 81/18723 | 4.02e-08 | 1.31e-06 | 43 |
GO:00108216 | Liver | Cirrhotic | regulation of mitochondrion organization | 62/4634 | 144/18723 | 1.09e-06 | 2.22e-05 | 62 |
GO:001050811 | Liver | Cirrhotic | positive regulation of autophagy | 51/4634 | 124/18723 | 4.25e-05 | 5.03e-04 | 51 |
GO:19031465 | Liver | Cirrhotic | regulation of autophagy of mitochondrion | 18/4634 | 33/18723 | 2.33e-04 | 2.11e-03 | 18 |
GO:19035995 | Liver | Cirrhotic | positive regulation of autophagy of mitochondrion | 9/4634 | 12/18723 | 3.59e-04 | 3.03e-03 | 9 |
GO:00108223 | Liver | Cirrhotic | positive regulation of mitochondrion organization | 30/4634 | 74/18723 | 1.97e-03 | 1.23e-02 | 30 |
GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
GO:003133122 | Liver | HCC | positive regulation of cellular catabolic process | 295/7958 | 427/18723 | 3.20e-29 | 1.45e-26 | 295 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMKK2 | SNV | Missense_Mutation | | c.854N>T | p.Ser285Phe | p.S285F | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAMKK2 | SNV | Missense_Mutation | rs200801054 | c.289N>T | p.Arg97Cys | p.R97C | Q96RR4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.889) | TCGA-BH-A18I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CAMKK2 | SNV | Missense_Mutation | | c.859N>A | p.Asp287Asn | p.D287N | Q96RR4 | protein_coding | tolerated(0.1) | benign(0.374) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CAMKK2 | SNV | Missense_Mutation | | c.17N>G | p.Ser6Cys | p.S6C | Q96RR4 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.533) | TCGA-FU-A5XV-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.55N>A | p.Glu19Lys | p.E19K | Q96RR4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.022) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAMKK2 | SNV | Missense_Mutation | | c.1520N>G | p.Glu507Gly | p.E507G | Q96RR4 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAMKK2 | SNV | Missense_Mutation | novel | c.1371N>T | p.Glu457Asp | p.E457D | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.1474N>T | p.Arg492Cys | p.R492C | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.802N>A | p.Glu268Lys | p.E268K | Q96RR4 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.1746G>T | p.Glu582Asp | p.E582D | Q96RR4 | protein_coding | tolerated_low_confidence(0.58) | benign(0) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | PF-562271 | PF-00562271 | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | inhibitor | 178101957 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | US9623028, Compound 101 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | CQ7 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | JNJ-7706621 | JNJ-7706621 | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | DOVITINIB | DOVITINIB | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | US9623028, Compound 79 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | AST-487 | AST-487 | |