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Gene: C6orf89 |
Gene summary for C6ORF89 |
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Gene information | Species | Human | Gene symbol | C6orf89 | Gene ID | 221477 |
Gene name | chromosome 6 open reading frame 89 | |
Gene Alias | BRAP | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RCY0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221477 | C6orf89 | LZE2T | Human | Esophagus | ESCC | 1.59e-04 | 7.28e-01 | 0.082 |
221477 | C6orf89 | LZE4T | Human | Esophagus | ESCC | 4.93e-12 | 3.68e-01 | 0.0811 |
221477 | C6orf89 | LZE7T | Human | Esophagus | ESCC | 1.30e-04 | 2.78e-01 | 0.0667 |
221477 | C6orf89 | LZE8T | Human | Esophagus | ESCC | 3.06e-11 | 3.45e-01 | 0.067 |
221477 | C6orf89 | LZE20T | Human | Esophagus | ESCC | 5.01e-09 | 4.54e-01 | 0.0662 |
221477 | C6orf89 | LZE22T | Human | Esophagus | ESCC | 1.66e-02 | 2.19e-01 | 0.068 |
221477 | C6orf89 | LZE24T | Human | Esophagus | ESCC | 3.44e-22 | 5.50e-01 | 0.0596 |
221477 | C6orf89 | LZE6T | Human | Esophagus | ESCC | 4.60e-05 | 1.77e-01 | 0.0845 |
221477 | C6orf89 | P1T-E | Human | Esophagus | ESCC | 3.16e-08 | 4.81e-01 | 0.0875 |
221477 | C6orf89 | P2T-E | Human | Esophagus | ESCC | 3.03e-45 | 7.72e-01 | 0.1177 |
221477 | C6orf89 | P4T-E | Human | Esophagus | ESCC | 6.00e-25 | 5.74e-01 | 0.1323 |
221477 | C6orf89 | P5T-E | Human | Esophagus | ESCC | 2.55e-13 | 3.81e-01 | 0.1327 |
221477 | C6orf89 | P8T-E | Human | Esophagus | ESCC | 5.15e-23 | 4.66e-01 | 0.0889 |
221477 | C6orf89 | P9T-E | Human | Esophagus | ESCC | 5.01e-13 | 2.90e-01 | 0.1131 |
221477 | C6orf89 | P10T-E | Human | Esophagus | ESCC | 1.06e-25 | 4.08e-01 | 0.116 |
221477 | C6orf89 | P11T-E | Human | Esophagus | ESCC | 1.55e-20 | 8.50e-01 | 0.1426 |
221477 | C6orf89 | P12T-E | Human | Esophagus | ESCC | 2.20e-22 | 4.38e-01 | 0.1122 |
221477 | C6orf89 | P15T-E | Human | Esophagus | ESCC | 4.43e-28 | 5.77e-01 | 0.1149 |
221477 | C6orf89 | P16T-E | Human | Esophagus | ESCC | 2.11e-23 | 4.81e-01 | 0.1153 |
221477 | C6orf89 | P17T-E | Human | Esophagus | ESCC | 2.68e-13 | 6.70e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003105621 | Liver | HCC | regulation of histone modification | 99/7958 | 152/18723 | 1.40e-08 | 3.40e-07 | 99 |
GO:004578711 | Liver | HCC | positive regulation of cell cycle | 172/7958 | 313/18723 | 5.29e-06 | 6.58e-05 | 172 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:0031058 | Liver | HCC | positive regulation of histone modification | 58/7958 | 92/18723 | 5.55e-05 | 5.21e-04 | 58 |
GO:0098732 | Liver | HCC | macromolecule deacylation | 67/7958 | 116/18723 | 6.46e-04 | 3.99e-03 | 67 |
GO:00356011 | Liver | HCC | protein deacylation | 64/7958 | 112/18723 | 1.23e-03 | 6.83e-03 | 64 |
GO:0090311 | Liver | HCC | regulation of protein deacetylation | 30/7958 | 48/18723 | 4.10e-03 | 1.78e-02 | 30 |
GO:00064761 | Liver | HCC | protein deacetylation | 55/7958 | 101/18723 | 1.01e-02 | 3.79e-02 | 55 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:00457879 | Oral cavity | OSCC | positive regulation of cell cycle | 173/7305 | 313/18723 | 3.28e-09 | 7.44e-08 | 173 |
GO:00356014 | Oral cavity | OSCC | protein deacylation | 74/7305 | 112/18723 | 5.88e-09 | 1.26e-07 | 74 |
GO:00310567 | Oral cavity | OSCC | regulation of histone modification | 94/7305 | 152/18723 | 9.57e-09 | 1.99e-07 | 94 |
GO:00987324 | Oral cavity | OSCC | macromolecule deacylation | 74/7305 | 116/18723 | 5.52e-08 | 1.01e-06 | 74 |
GO:00064764 | Oral cavity | OSCC | protein deacetylation | 66/7305 | 101/18723 | 7.36e-08 | 1.30e-06 | 66 |
GO:00310582 | Oral cavity | OSCC | positive regulation of histone modification | 60/7305 | 92/18723 | 3.17e-07 | 4.79e-06 | 60 |
GO:00165753 | Oral cavity | OSCC | histone deacetylation | 54/7305 | 82/18723 | 7.68e-07 | 1.08e-05 | 54 |
GO:005067310 | Oral cavity | OSCC | epithelial cell proliferation | 212/7305 | 437/18723 | 2.82e-05 | 2.61e-04 | 212 |
GO:0090312 | Oral cavity | OSCC | positive regulation of protein deacetylation | 20/7305 | 25/18723 | 3.47e-05 | 3.11e-04 | 20 |
GO:0031065 | Oral cavity | OSCC | positive regulation of histone deacetylation | 15/7305 | 19/18723 | 4.64e-04 | 2.76e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf89 | SNV | Missense_Mutation | rs143348146 | c.748N>T | p.Arg250Cys | p.R250C | Q6UWU4 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
C6orf89 | SNV | Missense_Mutation | c.655N>A | p.Gly219Arg | p.G219R | Q6UWU4 | protein_coding | tolerated(0.08) | benign(0.441) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
C6orf89 | SNV | Missense_Mutation | c.772N>G | p.His258Asp | p.H258D | Q6UWU4 | protein_coding | tolerated(0.21) | benign(0.023) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
C6orf89 | SNV | Missense_Mutation | rs779924954 | c.218N>A | p.Ala73Glu | p.A73E | Q6UWU4 | protein_coding | deleterious(0) | benign(0.086) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | c.353N>G | p.Ile118Ser | p.I118S | Q6UWU4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C6orf89 | SNV | Missense_Mutation | rs79686273 | c.979N>A | p.Asp327Asn | p.D327N | Q6UWU4 | protein_coding | tolerated(0.85) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs751486634 | c.923N>A | p.Arg308Gln | p.R308Q | Q6UWU4 | protein_coding | tolerated(0.33) | possibly_damaging(0.525) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs571648523 | c.313N>T | p.Arg105Cys | p.R105C | Q6UWU4 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.664N>C | p.Ala222Pro | p.A222P | Q6UWU4 | protein_coding | tolerated(0.06) | benign(0.417) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.794N>T | p.Ala265Val | p.A265V | Q6UWU4 | protein_coding | tolerated(0.69) | benign(0.015) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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