Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/BTBD10_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/BTBD10_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/BTBD10_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/BTBD10_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/BTBD10_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00443423 | Esophagus | ESCC | type B pancreatic cell proliferation | 15/8552 | 21/18723 | 1.54e-02 | 4.96e-02 | 15 |
GO:007099720 | Oral cavity | OSCC | neuron death | 202/7305 | 361/18723 | 3.75e-11 | 1.23e-09 | 202 |
GO:190121420 | Oral cavity | OSCC | regulation of neuron death | 174/7305 | 319/18723 | 1.09e-08 | 2.23e-07 | 174 |
GO:005067310 | Oral cavity | OSCC | epithelial cell proliferation | 212/7305 | 437/18723 | 2.82e-05 | 2.61e-04 | 212 |
GO:19012159 | Oral cavity | OSCC | negative regulation of neuron death | 104/7305 | 208/18723 | 7.90e-04 | 4.27e-03 | 104 |
GO:0070997110 | Oral cavity | LP | neuron death | 135/4623 | 361/18723 | 4.31e-08 | 1.52e-06 | 135 |
GO:1901214110 | Oral cavity | LP | regulation of neuron death | 115/4623 | 319/18723 | 3.39e-06 | 7.19e-05 | 115 |
GO:190121515 | Oral cavity | LP | negative regulation of neuron death | 69/4623 | 208/18723 | 3.50e-03 | 2.34e-02 | 69 |
GO:005067319 | Skin | AK | epithelial cell proliferation | 86/1910 | 437/18723 | 1.52e-09 | 1.43e-07 | 86 |
GO:007099728 | Skin | AK | neuron death | 63/1910 | 361/18723 | 1.50e-05 | 2.94e-04 | 63 |
GO:190121425 | Skin | AK | regulation of neuron death | 57/1910 | 319/18723 | 1.87e-05 | 3.52e-04 | 57 |
GO:00443424 | Skin | AK | type B pancreatic cell proliferation | 8/1910 | 21/18723 | 6.95e-04 | 5.94e-03 | 8 |
GO:190121517 | Skin | AK | negative regulation of neuron death | 34/1910 | 208/18723 | 3.87e-03 | 2.29e-02 | 34 |
GO:007099729 | Skin | cSCC | neuron death | 133/4864 | 361/18723 | 2.91e-06 | 4.58e-05 | 133 |
GO:190121426 | Skin | cSCC | regulation of neuron death | 112/4864 | 319/18723 | 1.71e-04 | 1.48e-03 | 112 |
GO:005067324 | Skin | cSCC | epithelial cell proliferation | 144/4864 | 437/18723 | 6.07e-04 | 4.38e-03 | 144 |
GO:004434211 | Skin | cSCC | type B pancreatic cell proliferation | 11/4864 | 21/18723 | 8.71e-03 | 4.01e-02 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTBD10 | SNV | Missense_Mutation | rs760524210 | c.218G>A | p.Arg73Gln | p.R73Q | Q9BSF8 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.836) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
BTBD10 | SNV | Missense_Mutation | | c.1426N>T | p.Pro476Ser | p.P476S | Q9BSF8 | protein_coding | deleterious_low_confidence(0.04) | benign(0) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
BTBD10 | SNV | Missense_Mutation | novel | c.704N>A | p.Ala235Glu | p.A235E | Q9BSF8 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-OL-A6VO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
BTBD10 | SNV | Missense_Mutation | rs771981722 | c.565G>C | p.Asp189His | p.D189H | Q9BSF8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BTBD10 | SNV | Missense_Mutation | novel | c.1375N>A | p.Glu459Lys | p.E459K | Q9BSF8 | protein_coding | tolerated(0.06) | possibly_damaging(0.79) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
BTBD10 | SNV | Missense_Mutation | novel | c.370C>G | p.Gln124Glu | p.Q124E | Q9BSF8 | protein_coding | tolerated_low_confidence(0.16) | benign(0.099) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BTBD10 | SNV | Missense_Mutation | | c.152N>T | p.Gly51Val | p.G51V | Q9BSF8 | protein_coding | tolerated_low_confidence(0.17) | benign(0.001) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
BTBD10 | SNV | Missense_Mutation | | c.529G>A | p.Val177Met | p.V177M | Q9BSF8 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BTBD10 | SNV | Missense_Mutation | novel | c.1020N>C | p.Glu340Asp | p.E340D | Q9BSF8 | protein_coding | tolerated(0.06) | possibly_damaging(0.897) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BTBD10 | SNV | Missense_Mutation | | c.218G>T | p.Arg73Leu | p.R73L | Q9BSF8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.493) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |