|
Gene: BPIFB1 |
Gene summary for BPIFB1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | BPIFB1 | Gene ID | 92747 |
Gene name | BPI fold containing family B member 1 | |
Gene Alias | C20orf114 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | Q8TDL5 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92747 | BPIFB1 | CA_HPV_1 | Human | Cervix | CC | 4.88e-24 | -6.78e-01 | 0.0264 |
92747 | BPIFB1 | CA_HPV_2 | Human | Cervix | CC | 1.95e-18 | -6.39e-01 | 0.0391 |
92747 | BPIFB1 | CA_HPV_3 | Human | Cervix | CC | 1.18e-12 | -6.32e-01 | 0.0414 |
92747 | BPIFB1 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 6.32e-11 | -6.07e-01 | 0.0116 |
92747 | BPIFB1 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.58e-12 | -5.85e-01 | 0.0208 |
92747 | BPIFB1 | N_HPV_1 | Human | Cervix | N_HPV | 5.37e-05 | -5.17e-01 | 0.0079 |
92747 | BPIFB1 | N_HPV_2 | Human | Cervix | N_HPV | 4.90e-05 | -5.04e-01 | -0.0131 |
92747 | BPIFB1 | CCI_1 | Human | Cervix | CC | 6.18e-06 | -6.78e-01 | 0.528 |
92747 | BPIFB1 | CCI_2 | Human | Cervix | CC | 2.44e-05 | -6.78e-01 | 0.5249 |
92747 | BPIFB1 | CCI_3 | Human | Cervix | CC | 2.45e-08 | -6.78e-01 | 0.516 |
92747 | BPIFB1 | CCII_1 | Human | Cervix | CC | 5.08e-12 | -6.78e-01 | 0.3249 |
92747 | BPIFB1 | Tumor | Human | Cervix | CC | 4.88e-24 | -6.78e-01 | 0.1241 |
92747 | BPIFB1 | sample1 | Human | Cervix | CC | 1.89e-07 | -6.37e-01 | 0.0959 |
92747 | BPIFB1 | sample3 | Human | Cervix | CC | 2.75e-23 | -6.78e-01 | 0.1387 |
92747 | BPIFB1 | H2 | Human | Cervix | HSIL_HPV | 1.84e-30 | 8.72e-01 | 0.0632 |
92747 | BPIFB1 | L1 | Human | Cervix | CC | 2.67e-13 | -6.78e-01 | 0.0802 |
92747 | BPIFB1 | T1 | Human | Cervix | CC | 1.16e-22 | -6.78e-01 | 0.0918 |
92747 | BPIFB1 | T2 | Human | Cervix | CC | 2.01e-06 | 8.48e-01 | 0.0709 |
92747 | BPIFB1 | T3 | Human | Cervix | CC | 2.05e-24 | -6.78e-01 | 0.1389 |
92747 | BPIFB1 | C09 | Human | Oral cavity | OSCC | 5.71e-30 | 1.66e+00 | 0.1431 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00022243 | Oral cavity | OSCC | toll-like receptor signaling pathway | 63/7305 | 121/18723 | 2.36e-03 | 1.04e-02 | 63 |
GO:00027646 | Oral cavity | OSCC | immune response-regulating signaling pathway | 212/7305 | 468/18723 | 2.93e-03 | 1.27e-02 | 212 |
GO:00341424 | Oral cavity | OSCC | toll-like receptor 4 signaling pathway | 25/7305 | 43/18723 | 8.52e-03 | 3.09e-02 | 25 |
GO:00622075 | Prostate | Tumor | regulation of pattern recognition receptor signaling pathway | 28/3246 | 105/18723 | 1.08e-02 | 4.47e-02 | 28 |
GO:0002764 | Stomach | GC | immune response-regulating signaling pathway | 46/1159 | 468/18723 | 1.31e-03 | 1.46e-02 | 46 |
GO:00027641 | Stomach | CAG with IM | immune response-regulating signaling pathway | 43/1050 | 468/18723 | 1.03e-03 | 1.29e-02 | 43 |
GO:0062207 | Stomach | CAG with IM | regulation of pattern recognition receptor signaling pathway | 13/1050 | 105/18723 | 5.85e-03 | 4.55e-02 | 13 |
GO:00027642 | Stomach | CSG | immune response-regulating signaling pathway | 43/1034 | 468/18723 | 7.58e-04 | 1.04e-02 | 43 |
GO:00622071 | Stomach | CSG | regulation of pattern recognition receptor signaling pathway | 13/1034 | 105/18723 | 5.15e-03 | 4.18e-02 | 13 |
GO:00341422 | Stomach | SIM | toll-like receptor 4 signaling pathway | 7/708 | 43/18723 | 1.06e-03 | 1.39e-02 | 7 |
GO:0034143 | Stomach | SIM | regulation of toll-like receptor 4 signaling pathway | 5/708 | 27/18723 | 3.08e-03 | 2.94e-02 | 5 |
Page: 1 2 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BPIFB1 | SNV | Missense_Mutation | c.129N>T | p.Glu43Asp | p.E43D | Q8TDL5 | protein_coding | tolerated(0.13) | possibly_damaging(0.516) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BPIFB1 | SNV | Missense_Mutation | c.629N>C | p.Gly210Ala | p.G210A | Q8TDL5 | protein_coding | deleterious(0.03) | benign(0.014) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BPIFB1 | SNV | Missense_Mutation | c.1402C>T | p.Leu468Phe | p.L468F | Q8TDL5 | protein_coding | deleterious(0.03) | possibly_damaging(0.753) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BPIFB1 | SNV | Missense_Mutation | c.988N>A | p.Asp330Asn | p.D330N | Q8TDL5 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BPIFB1 | SNV | Missense_Mutation | rs376198152 | c.401C>T | p.Thr134Met | p.T134M | Q8TDL5 | protein_coding | deleterious(0.05) | benign(0.286) | TCGA-C8-A12U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BPIFB1 | insertion | Frame_Shift_Ins | novel | c.94_95insTGAGGCAGGAGAATGGTGTGAACTCAGGAGGTGGA | p.Gly32ValfsTer21 | p.G32Vfs*21 | Q8TDL5 | protein_coding | TCGA-AN-A0FD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BPIFB1 | SNV | Missense_Mutation | novel | c.322N>A | p.Leu108Met | p.L108M | Q8TDL5 | protein_coding | tolerated(0.09) | possibly_damaging(0.871) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BPIFB1 | SNV | Missense_Mutation | novel | c.172N>G | p.Leu58Val | p.L58V | Q8TDL5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
BPIFB1 | SNV | Missense_Mutation | c.4N>A | p.Ala2Thr | p.A2T | Q8TDL5 | protein_coding | deleterious(0.04) | benign(0.023) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BPIFB1 | SNV | Missense_Mutation | rs758437993 | c.812N>A | p.Thr271Lys | p.T271K | Q8TDL5 | protein_coding | tolerated(0.08) | benign(0.025) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |