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Gene: AP1M2 |
Gene summary for AP1M2 |
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Gene information | Species | Human | Gene symbol | AP1M2 | Gene ID | 10053 |
Gene name | adaptor related protein complex 1 subunit mu 2 | |
Gene Alias | AP1-mu2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q53GI5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10053 | AP1M2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.25e-14 | 4.89e-01 | 0.0155 |
10053 | AP1M2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.27e-15 | 7.36e-01 | -0.1808 |
10053 | AP1M2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.54e-15 | 7.96e-01 | -0.0811 |
10053 | AP1M2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.40e-08 | 5.48e-01 | -0.1088 |
10053 | AP1M2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.45e-22 | 7.40e-01 | -0.1954 |
10053 | AP1M2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.10e-09 | 1.15e+00 | -0.2602 |
10053 | AP1M2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.33e-02 | 6.21e-01 | -0.2196 |
10053 | AP1M2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.44e-07 | 6.83e-01 | -0.1207 |
10053 | AP1M2 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.96e-10 | 6.19e-01 | -0.1526 |
10053 | AP1M2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.94e-22 | 7.33e-01 | -0.1464 |
10053 | AP1M2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.66e-06 | 4.31e-01 | -0.1001 |
10053 | AP1M2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.55e-22 | 9.66e-01 | -0.059 |
10053 | AP1M2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.79e-03 | 5.19e-01 | -0.2061 |
10053 | AP1M2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.79e-06 | 8.37e-01 | -0.1462 |
10053 | AP1M2 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.19e-09 | 6.92e-01 | -0.0842 |
10053 | AP1M2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.71e-03 | 3.59e-01 | -0.0179 |
10053 | AP1M2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.45e-15 | 5.67e-01 | 0.096 |
10053 | AP1M2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.05e-03 | 6.39e-01 | 0.0446 |
10053 | AP1M2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.23e-07 | 7.66e-01 | 0.0528 |
10053 | AP1M2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.46e-03 | 6.01e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069033 | Colorectum | FAP | vesicle targeting | 14/2622 | 45/18723 | 2.53e-03 | 1.99e-02 | 14 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:005165611 | Liver | Cirrhotic | establishment of organelle localization | 128/4634 | 390/18723 | 1.78e-04 | 1.67e-03 | 128 |
GO:00069034 | Liver | Cirrhotic | vesicle targeting | 22/4634 | 45/18723 | 3.90e-04 | 3.23e-03 | 22 |
GO:005165011 | Liver | Cirrhotic | establishment of vesicle localization | 58/4634 | 161/18723 | 8.98e-04 | 6.44e-03 | 58 |
GO:005164811 | Liver | Cirrhotic | vesicle localization | 62/4634 | 177/18723 | 1.37e-03 | 9.18e-03 | 62 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:005165021 | Liver | HCC | establishment of vesicle localization | 103/7958 | 161/18723 | 2.94e-08 | 6.69e-07 | 103 |
GO:005164821 | Liver | HCC | vesicle localization | 107/7958 | 177/18723 | 1.05e-06 | 1.57e-05 | 107 |
GO:000690311 | Liver | HCC | vesicle targeting | 34/7958 | 45/18723 | 6.75e-06 | 8.08e-05 | 34 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:00069037 | Oral cavity | OSCC | vesicle targeting | 38/7305 | 45/18723 | 4.49e-10 | 1.19e-08 | 38 |
GO:00516509 | Oral cavity | OSCC | establishment of vesicle localization | 101/7305 | 161/18723 | 8.79e-10 | 2.17e-08 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa051703 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa051706 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa051707 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa051709 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa0517012 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
hsa0517027 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP1M2 | SNV | Missense_Mutation | rs372188688 | c.478N>T | p.Arg160Cys | p.R160C | Q9Y6Q5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP1M2 | SNV | Missense_Mutation | c.837C>G | p.Ile279Met | p.I279M | Q9Y6Q5 | protein_coding | deleterious(0.01) | benign(0.358) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
AP1M2 | SNV | Missense_Mutation | c.508G>A | p.Glu170Lys | p.E170K | Q9Y6Q5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
AP1M2 | SNV | Missense_Mutation | rs754967797 | c.541N>A | p.Leu181Met | p.L181M | Q9Y6Q5 | protein_coding | tolerated(0.49) | benign(0.076) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AP1M2 | SNV | Missense_Mutation | novel | c.346N>A | p.Glu116Lys | p.E116K | Q9Y6Q5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AP1M2 | SNV | Missense_Mutation | c.1135N>A | p.Gly379Arg | p.G379R | Q9Y6Q5 | protein_coding | tolerated(0.5) | benign(0) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | |
AP1M2 | SNV | Missense_Mutation | c.889G>A | p.Val297Ile | p.V297I | Q9Y6Q5 | protein_coding | tolerated(0.53) | benign(0.024) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
AP1M2 | SNV | Missense_Mutation | c.158G>A | p.Gly53Asp | p.G53D | Q9Y6Q5 | protein_coding | tolerated(0.9) | benign(0.003) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AP1M2 | SNV | Missense_Mutation | rs370107597 | c.431N>T | p.Thr144Met | p.T144M | Q9Y6Q5 | protein_coding | tolerated(0.1) | benign(0.103) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AP1M2 | SNV | Missense_Mutation | rs780844145 | c.133N>A | p.Ala45Thr | p.A45T | Q9Y6Q5 | protein_coding | tolerated(0.59) | benign(0.005) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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