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Gene: ANKH |
Gene summary for ANKH |
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Gene information | Species | Human | Gene symbol | ANKH | Gene ID | 56172 |
Gene name | ANKH inorganic pyrophosphate transport regulator | |
Gene Alias | ANK | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9HCJ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56172 | ANKH | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.58e-08 | 8.25e-01 | -0.0811 |
56172 | ANKH | HTA11_78_2000001011 | Human | Colorectum | AD | 2.10e-04 | 6.33e-01 | -0.1088 |
56172 | ANKH | HTA11_347_2000001011 | Human | Colorectum | AD | 1.62e-02 | 3.75e-01 | -0.1954 |
56172 | ANKH | HTA11_866_2000001011 | Human | Colorectum | AD | 1.34e-05 | 5.56e-01 | -0.1001 |
56172 | ANKH | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.05e-07 | 1.12e+00 | -0.059 |
56172 | ANKH | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.59e-02 | 7.07e-01 | 0.0131 |
56172 | ANKH | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-02 | 6.33e-01 | 0.0338 |
56172 | ANKH | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.22e-03 | 7.16e-01 | 0.0112 |
56172 | ANKH | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.96e-10 | 9.35e-01 | 0.0588 |
56172 | ANKH | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.27e-04 | 9.19e-01 | 0.3487 |
56172 | ANKH | A001-C-207 | Human | Colorectum | FAP | 7.46e-04 | 1.29e-01 | 0.1278 |
56172 | ANKH | A015-C-203 | Human | Colorectum | FAP | 2.60e-28 | -1.75e-01 | -0.1294 |
56172 | ANKH | A015-C-204 | Human | Colorectum | FAP | 4.71e-06 | 1.31e-01 | -0.0228 |
56172 | ANKH | A014-C-040 | Human | Colorectum | FAP | 8.36e-05 | 3.99e-02 | -0.1184 |
56172 | ANKH | A002-C-201 | Human | Colorectum | FAP | 3.66e-16 | 1.75e-01 | 0.0324 |
56172 | ANKH | A002-C-203 | Human | Colorectum | FAP | 8.78e-08 | 3.25e-01 | 0.2786 |
56172 | ANKH | A001-C-119 | Human | Colorectum | FAP | 8.14e-05 | -2.11e-01 | -0.1557 |
56172 | ANKH | A001-C-108 | Human | Colorectum | FAP | 4.42e-15 | -1.17e-01 | -0.0272 |
56172 | ANKH | A002-C-205 | Human | Colorectum | FAP | 1.31e-22 | -1.63e-01 | -0.1236 |
56172 | ANKH | A015-C-005 | Human | Colorectum | FAP | 6.15e-09 | -3.68e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00701672 | Thyroid | ATC | regulation of biomineral tissue development | 44/6293 | 97/18723 | 1.05e-02 | 3.81e-02 | 44 |
GO:0030500 | Thyroid | ATC | regulation of bone mineralization | 36/6293 | 78/18723 | 1.43e-02 | 4.92e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKH | SNV | Missense_Mutation | c.563N>T | p.Glu188Val | p.E188V | Q9HCJ1 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKH | SNV | Missense_Mutation | rs142872069 | c.668N>T | p.Arg223Ile | p.R223I | Q9HCJ1 | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | c.1118N>A | p.Ile373Asn | p.I373N | Q9HCJ1 | protein_coding | deleterious(0) | possibly_damaging(0.467) | TCGA-B6-A0WS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKH | SNV | Missense_Mutation | c.383N>T | p.Thr128Met | p.T128M | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ANKH | insertion | Frame_Shift_Ins | novel | c.1408_1409insGT | p.Ser470CysfsTer4 | p.S470Cfs*4 | Q9HCJ1 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ANKH | insertion | In_Frame_Ins | novel | c.1406_1407insAAGAAAAAGGCAGGCCCTTTGTGTCTACCGTTTTCAGTG | p.Asp469delinsGluArgLysArgGlnAlaLeuCysValTyrArgPheGlnCys | p.D469delinsERKRQALCVYRFQC | Q9HCJ1 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ANKH | insertion | In_Frame_Ins | novel | c.1142_1143insGCCACTTCAATA | p.Val381_Thr382insProLeuGlnTyr | p.V381_T382insPLQY | Q9HCJ1 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKH | SNV | Missense_Mutation | novel | c.1318G>C | p.Glu440Gln | p.E440Q | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | c.851N>A | p.Pro284His | p.P284H | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKH | SNV | Missense_Mutation | c.1154C>T | p.Ala385Val | p.A385V | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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