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Gene: AMH |
Gene summary for AMH |
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Gene information | Species | Human | Gene symbol | AMH | Gene ID | 268 |
Gene name | anti-Mullerian hormone | |
Gene Alias | MIF | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P03971 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
268 | AMH | C38 | Human | Oral cavity | OSCC | 5.51e-08 | 5.68e-01 | 0.172 |
268 | AMH | LN38 | Human | Oral cavity | OSCC | 4.47e-05 | 6.16e-01 | 0.168 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091411 | Colorectum | SER | nucleoside triphosphate metabolic process | 41/2897 | 112/18723 | 3.46e-08 | 2.31e-06 | 41 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00346551 | Colorectum | SER | nucleobase-containing compound catabolic process | 88/2897 | 407/18723 | 5.53e-04 | 7.71e-03 | 88 |
GO:00194391 | Colorectum | SER | aromatic compound catabolic process | 98/2897 | 467/18723 | 8.09e-04 | 1.01e-02 | 98 |
GO:00061951 | Colorectum | SER | purine nucleotide catabolic process | 16/2897 | 46/18723 | 9.88e-04 | 1.17e-02 | 16 |
GO:00725231 | Colorectum | SER | purine-containing compound catabolic process | 17/2897 | 52/18723 | 1.53e-03 | 1.64e-02 | 17 |
GO:0009200 | Colorectum | SER | deoxyribonucleoside triphosphate metabolic process | 8/2897 | 17/18723 | 2.12e-03 | 2.06e-02 | 8 |
GO:00343401 | Colorectum | SER | response to type I interferon | 17/2897 | 58/18723 | 5.50e-03 | 4.07e-02 | 17 |
GO:0009166 | Colorectum | SER | nucleotide catabolic process | 20/2897 | 73/18723 | 6.34e-03 | 4.56e-02 | 20 |
GO:00061632 | Colorectum | MSS | purine nucleotide metabolic process | 128/3467 | 396/18723 | 2.04e-11 | 3.02e-09 | 128 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:00346552 | Colorectum | MSS | nucleobase-containing compound catabolic process | 129/3467 | 407/18723 | 7.48e-11 | 8.18e-09 | 129 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa043506 | Oral cavity | OSCC | TGF-beta signaling pathway | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0435013 | Oral cavity | OSCC | TGF-beta signaling pathway | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMH | SNV | Missense_Mutation | novel | c.1441G>A | p.Glu481Lys | p.E481K | P03971 | protein_coding | deleterious(0.05) | probably_damaging(0.969) | TCGA-E9-A2JS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
AMH | SNV | Missense_Mutation | c.509N>A | p.Pro170His | p.P170H | P03971 | protein_coding | tolerated(0.06) | benign(0.037) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AMH | SNV | Missense_Mutation | rs371130597 | c.346N>T | p.Arg116Trp | p.R116W | P03971 | protein_coding | deleterious(0) | benign(0.35) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AMH | insertion | Frame_Shift_Ins | rs769922506 | c.208dupC | p.Leu70ProfsTer11 | p.L70Pfs*11 | P03971 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
AMH | SNV | Missense_Mutation | novel | c.41C>A | p.Ser14Tyr | p.S14Y | P03971 | protein_coding | tolerated_low_confidence(0.59) | benign(0.086) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AMH | deletion | Frame_Shift_Del | c.203delN | p.Leu70CysfsTer7 | p.L70Cfs*7 | P03971 | protein_coding | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
AMH | insertion | Frame_Shift_Ins | novel | c.470_471insC | p.Glu160ArgfsTer14 | p.E160Rfs*14 | P03971 | protein_coding | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
AMH | insertion | Frame_Shift_Ins | novel | c.283dupC | p.Arg95ProfsTer13 | p.R95Pfs*13 | P03971 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
AMH | SNV | Missense_Mutation | c.356N>T | p.Gly119Val | p.G119V | P03971 | protein_coding | tolerated(0.05) | benign(0.297) | TCGA-ED-A7XP-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
AMH | SNV | Missense_Mutation | novel | c.1438N>T | p.Pro480Ser | p.P480S | P03971 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7576-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | DES | DIETHYLSTILBESTROL | 9751506 | |
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | GONADOTROPINS | 347363,8810722 | ||
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | HUMAN CHORIONIC GONADOTROPIN | 10443662 | ||
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | DIETHYLSTILBESTROL | DIETHYLSTILBESTROL | 2286533 | |
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | TESTOSTERONE | TESTOSTERONE | 11248089,11545286,1292985,14584782,11315948,7962305,7818099 | |
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | RETINOIC ACID | 8326606,7815634 | ||
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | HORMONES | 12428210 | ||
268 | AMH | GROWTH FACTOR, HORMONE ACTIVITY, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | ETHINYL ESTRADIOL | 4049280 |
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