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Gene: ADPGK |
Gene summary for ADPGK |
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Gene information | Species | Human | Gene symbol | ADPGK | Gene ID | 83440 |
Gene name | ADP dependent glucokinase | |
Gene Alias | 2610017G09Rik | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q9BRR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83440 | ADPGK | LZE4T | Human | Esophagus | ESCC | 2.01e-09 | 2.02e-01 | 0.0811 |
83440 | ADPGK | LZE5T | Human | Esophagus | ESCC | 2.36e-06 | 2.66e-01 | 0.0514 |
83440 | ADPGK | LZE7T | Human | Esophagus | ESCC | 9.47e-07 | 3.80e-01 | 0.0667 |
83440 | ADPGK | LZE20T | Human | Esophagus | ESCC | 7.82e-05 | 1.33e-01 | 0.0662 |
83440 | ADPGK | LZE24T | Human | Esophagus | ESCC | 1.78e-15 | 2.58e-01 | 0.0596 |
83440 | ADPGK | LZE21T | Human | Esophagus | ESCC | 1.59e-03 | 1.57e-01 | 0.0655 |
83440 | ADPGK | P1T-E | Human | Esophagus | ESCC | 1.47e-07 | 3.18e-01 | 0.0875 |
83440 | ADPGK | P2T-E | Human | Esophagus | ESCC | 6.71e-25 | 3.91e-01 | 0.1177 |
83440 | ADPGK | P4T-E | Human | Esophagus | ESCC | 1.15e-32 | 6.71e-01 | 0.1323 |
83440 | ADPGK | P5T-E | Human | Esophagus | ESCC | 5.30e-09 | 1.16e-01 | 0.1327 |
83440 | ADPGK | P8T-E | Human | Esophagus | ESCC | 1.14e-32 | 4.50e-01 | 0.0889 |
83440 | ADPGK | P9T-E | Human | Esophagus | ESCC | 6.94e-22 | 3.98e-01 | 0.1131 |
83440 | ADPGK | P10T-E | Human | Esophagus | ESCC | 3.45e-42 | 6.01e-01 | 0.116 |
83440 | ADPGK | P11T-E | Human | Esophagus | ESCC | 1.08e-14 | 6.19e-01 | 0.1426 |
83440 | ADPGK | P12T-E | Human | Esophagus | ESCC | 1.72e-28 | 4.82e-01 | 0.1122 |
83440 | ADPGK | P15T-E | Human | Esophagus | ESCC | 5.63e-33 | 5.93e-01 | 0.1149 |
83440 | ADPGK | P16T-E | Human | Esophagus | ESCC | 5.52e-26 | 5.38e-01 | 0.1153 |
83440 | ADPGK | P17T-E | Human | Esophagus | ESCC | 7.92e-09 | 2.90e-01 | 0.1278 |
83440 | ADPGK | P19T-E | Human | Esophagus | ESCC | 2.97e-09 | 4.75e-01 | 0.1662 |
83440 | ADPGK | P20T-E | Human | Esophagus | ESCC | 3.10e-21 | 4.74e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000616519 | Esophagus | ESCC | nucleoside diphosphate phosphorylation | 59/8552 | 99/18723 | 3.65e-03 | 1.49e-02 | 59 |
GO:00616203 | Esophagus | ESCC | glycolytic process through glucose-6-phosphate | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:000609620 | Esophagus | ESCC | glycolytic process | 48/8552 | 81/18723 | 9.54e-03 | 3.30e-02 | 48 |
GO:000675720 | Esophagus | ESCC | ATP generation from ADP | 48/8552 | 82/18723 | 1.29e-02 | 4.27e-02 | 48 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:001969322 | Liver | HCC | ribose phosphate metabolic process | 248/7958 | 396/18723 | 3.15e-16 | 2.70e-14 | 248 |
GO:000925922 | Liver | HCC | ribonucleotide metabolic process | 240/7958 | 385/18723 | 2.07e-15 | 1.51e-13 | 240 |
GO:000915022 | Liver | HCC | purine ribonucleotide metabolic process | 226/7958 | 368/18723 | 1.36e-13 | 7.69e-12 | 226 |
GO:007252122 | Liver | HCC | purine-containing compound metabolic process | 250/7958 | 416/18723 | 2.26e-13 | 1.24e-11 | 250 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:000616322 | Liver | HCC | purine nucleotide metabolic process | 236/7958 | 396/18723 | 3.59e-12 | 1.62e-10 | 236 |
GO:000600621 | Liver | HCC | glucose metabolic process | 128/7958 | 196/18723 | 8.60e-11 | 3.06e-09 | 128 |
GO:000609022 | Liver | HCC | pyruvate metabolic process | 73/7958 | 106/18723 | 3.52e-08 | 7.82e-07 | 73 |
GO:001605222 | Liver | HCC | carbohydrate catabolic process | 99/7958 | 154/18723 | 3.79e-08 | 8.30e-07 | 99 |
GO:000918522 | Liver | HCC | ribonucleoside diphosphate metabolic process | 72/7958 | 106/18723 | 1.05e-07 | 2.03e-06 | 72 |
GO:004603122 | Liver | HCC | ADP metabolic process | 63/7958 | 90/18723 | 1.17e-07 | 2.25e-06 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0001016 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0001017 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0120041 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0001022 | Liver | HCC | Glycolysis / Gluconeogenesis | 43/4020 | 67/8465 | 4.26e-03 | 1.29e-02 | 7.15e-03 | 43 |
hsa0120051 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0001032 | Liver | HCC | Glycolysis / Gluconeogenesis | 43/4020 | 67/8465 | 4.26e-03 | 1.29e-02 | 7.15e-03 | 43 |
hsa0120014 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa0001014 | Oral cavity | OSCC | Glycolysis / Gluconeogenesis | 40/3704 | 67/8465 | 6.08e-03 | 1.44e-02 | 7.31e-03 | 40 |
hsa0120015 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa0001015 | Oral cavity | OSCC | Glycolysis / Gluconeogenesis | 40/3704 | 67/8465 | 6.08e-03 | 1.44e-02 | 7.31e-03 | 40 |
hsa0120022 | Oral cavity | LP | Carbon metabolism | 62/2418 | 115/8465 | 8.38e-09 | 1.39e-07 | 8.99e-08 | 62 |
hsa0001023 | Oral cavity | LP | Glycolysis / Gluconeogenesis | 28/2418 | 67/8465 | 1.36e-02 | 4.44e-02 | 2.86e-02 | 28 |
hsa0120032 | Oral cavity | LP | Carbon metabolism | 62/2418 | 115/8465 | 8.38e-09 | 1.39e-07 | 8.99e-08 | 62 |
hsa0001033 | Oral cavity | LP | Glycolysis / Gluconeogenesis | 28/2418 | 67/8465 | 1.36e-02 | 4.44e-02 | 2.86e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADPGK | SNV | Missense_Mutation | rs192015434 | c.535N>A | p.Gly179Ser | p.G179S | Q9BRR6 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ADPGK | SNV | Missense_Mutation | c.889N>C | p.Glu297Gln | p.E297Q | Q9BRR6 | protein_coding | tolerated(0.06) | probably_damaging(0.97) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADPGK | SNV | Missense_Mutation | rs778341188 | c.710A>G | p.Asn237Ser | p.N237S | Q9BRR6 | protein_coding | tolerated(0.13) | possibly_damaging(0.898) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ADPGK | SNV | Missense_Mutation | c.1010N>A | p.Gly337Glu | p.G337E | Q9BRR6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADPGK | SNV | Missense_Mutation | c.1268N>T | p.Arg423Leu | p.R423L | Q9BRR6 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR | |
ADPGK | SNV | Missense_Mutation | novel | c.965N>A | p.Gly322Glu | p.G322E | Q9BRR6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3872-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ADPGK | SNV | Missense_Mutation | c.400N>G | p.Ser134Gly | p.S134G | Q9BRR6 | protein_coding | deleterious(0.01) | possibly_damaging(0.74) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ADPGK | SNV | Missense_Mutation | novel | c.1226N>G | p.Ala409Gly | p.A409G | Q9BRR6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ADPGK | SNV | Missense_Mutation | novel | c.1295N>G | p.Phe432Cys | p.F432C | Q9BRR6 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ADPGK | SNV | Missense_Mutation | c.365N>C | p.Phe122Ser | p.F122S | Q9BRR6 | protein_coding | tolerated(0.11) | benign(0.112) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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