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Gene: ABI2 |
Gene summary for ABI2 |
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Gene information | Species | Human | Gene symbol | ABI2 | Gene ID | 10152 |
Gene name | abl interactor 2 | |
Gene Alias | ABI-2 | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | F8WAL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10152 | ABI2 | LZE7T | Human | Esophagus | ESCC | 4.32e-14 | 4.83e-01 | 0.0667 |
10152 | ABI2 | LZE20T | Human | Esophagus | ESCC | 1.71e-03 | 6.07e-02 | 0.0662 |
10152 | ABI2 | LZE24T | Human | Esophagus | ESCC | 1.53e-14 | 4.69e-01 | 0.0596 |
10152 | ABI2 | P1T-E | Human | Esophagus | ESCC | 1.03e-02 | 3.34e-01 | 0.0875 |
10152 | ABI2 | P2T-E | Human | Esophagus | ESCC | 8.19e-37 | 7.02e-01 | 0.1177 |
10152 | ABI2 | P4T-E | Human | Esophagus | ESCC | 1.28e-27 | 6.33e-01 | 0.1323 |
10152 | ABI2 | P5T-E | Human | Esophagus | ESCC | 6.16e-11 | 2.27e-01 | 0.1327 |
10152 | ABI2 | P8T-E | Human | Esophagus | ESCC | 1.30e-21 | 4.23e-01 | 0.0889 |
10152 | ABI2 | P9T-E | Human | Esophagus | ESCC | 1.95e-09 | 3.15e-01 | 0.1131 |
10152 | ABI2 | P10T-E | Human | Esophagus | ESCC | 7.36e-38 | 5.71e-01 | 0.116 |
10152 | ABI2 | P11T-E | Human | Esophagus | ESCC | 4.29e-08 | 4.45e-01 | 0.1426 |
10152 | ABI2 | P12T-E | Human | Esophagus | ESCC | 1.80e-37 | 7.29e-01 | 0.1122 |
10152 | ABI2 | P15T-E | Human | Esophagus | ESCC | 7.06e-34 | 8.19e-01 | 0.1149 |
10152 | ABI2 | P16T-E | Human | Esophagus | ESCC | 4.74e-35 | 6.66e-01 | 0.1153 |
10152 | ABI2 | P17T-E | Human | Esophagus | ESCC | 4.83e-04 | 2.91e-01 | 0.1278 |
10152 | ABI2 | P20T-E | Human | Esophagus | ESCC | 2.18e-11 | 3.14e-01 | 0.1124 |
10152 | ABI2 | P21T-E | Human | Esophagus | ESCC | 3.77e-13 | 2.75e-01 | 0.1617 |
10152 | ABI2 | P22T-E | Human | Esophagus | ESCC | 2.64e-30 | 5.39e-01 | 0.1236 |
10152 | ABI2 | P23T-E | Human | Esophagus | ESCC | 4.58e-11 | 2.42e-01 | 0.108 |
10152 | ABI2 | P24T-E | Human | Esophagus | ESCC | 1.26e-28 | 4.86e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000806419 | Esophagus | ESCC | regulation of actin polymerization or depolymerization | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:003083218 | Esophagus | ESCC | regulation of actin filament length | 112/8552 | 189/18723 | 1.13e-04 | 7.85e-04 | 112 |
GO:003083320 | Esophagus | ESCC | regulation of actin filament polymerization | 103/8552 | 172/18723 | 1.19e-04 | 8.15e-04 | 103 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:006049118 | Esophagus | ESCC | regulation of cell projection assembly | 110/8552 | 188/18723 | 2.60e-04 | 1.58e-03 | 110 |
GO:012003218 | Esophagus | ESCC | regulation of plasma membrane bounded cell projection assembly | 108/8552 | 186/18723 | 4.37e-04 | 2.46e-03 | 108 |
GO:003431415 | Esophagus | ESCC | Arp2/3 complex-mediated actin nucleation | 28/8552 | 39/18723 | 8.57e-04 | 4.40e-03 | 28 |
GO:01200347 | Esophagus | ESCC | positive regulation of plasma membrane bounded cell projection assembly | 64/8552 | 105/18723 | 1.15e-03 | 5.70e-03 | 64 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:00343156 | Esophagus | ESCC | regulation of Arp2/3 complex-mediated actin nucleation | 16/8552 | 21/18723 | 4.47e-03 | 1.76e-02 | 16 |
GO:00450108 | Esophagus | ESCC | actin nucleation | 33/8552 | 52/18723 | 7.38e-03 | 2.65e-02 | 33 |
GO:009758116 | Esophagus | ESCC | lamellipodium organization | 53/8552 | 90/18723 | 7.92e-03 | 2.82e-02 | 53 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:190274515 | Esophagus | ESCC | positive regulation of lamellipodium organization | 24/8552 | 37/18723 | 1.46e-02 | 4.74e-02 | 24 |
GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
GO:000701512 | Liver | Cirrhotic | actin filament organization | 171/4634 | 442/18723 | 3.93e-11 | 2.30e-09 | 171 |
GO:190290312 | Liver | Cirrhotic | regulation of supramolecular fiber organization | 148/4634 | 383/18723 | 8.85e-10 | 4.08e-08 | 148 |
GO:003297012 | Liver | Cirrhotic | regulation of actin filament-based process | 152/4634 | 397/18723 | 1.12e-09 | 5.00e-08 | 152 |
GO:003295612 | Liver | Cirrhotic | regulation of actin cytoskeleton organization | 136/4634 | 358/18723 | 1.47e-08 | 5.49e-07 | 136 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481043 | Oral cavity | NEOLP | Regulation of actin cytoskeleton | 55/1112 | 229/8465 | 4.12e-06 | 3.86e-05 | 2.42e-05 | 55 |
hsa0481053 | Oral cavity | NEOLP | Regulation of actin cytoskeleton | 55/1112 | 229/8465 | 4.12e-06 | 3.86e-05 | 2.42e-05 | 55 |
hsa0481020 | Prostate | BPH | Regulation of actin cytoskeleton | 80/1718 | 229/8465 | 1.23e-07 | 1.31e-06 | 8.10e-07 | 80 |
hsa04810110 | Prostate | BPH | Regulation of actin cytoskeleton | 80/1718 | 229/8465 | 1.23e-07 | 1.31e-06 | 8.10e-07 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABI2 | SNV | Missense_Mutation | c.535N>G | p.Gln179Glu | p.Q179E | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ABI2 | SNV | Missense_Mutation | c.403N>T | p.Arg135Cys | p.R135C | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ABI2 | SNV | Missense_Mutation | c.1456N>A | p.Asp486Asn | p.D486N | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | ||
ABI2 | SNV | Missense_Mutation | novel | c.736A>T | p.Ser246Cys | p.S246C | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABI2 | SNV | Missense_Mutation | novel | c.512T>A | p.Leu171Gln | p.L171Q | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ABI2 | SNV | Missense_Mutation | novel | c.1525N>G | p.Met509Val | p.M509V | protein_coding | deleterious(0.05) | possibly_damaging(0.841) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ABI2 | SNV | Missense_Mutation | c.403C>T | p.Arg135Cys | p.R135C | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ABI2 | SNV | Missense_Mutation | c.1185N>T | p.Gln395His | p.Q395H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-CM-5344-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
ABI2 | SNV | Missense_Mutation | c.596N>A | p.Arg199His | p.R199H | protein_coding | deleterious(0.03) | possibly_damaging(0.847) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ABI2 | SNV | Missense_Mutation | novel | c.436N>A | p.Leu146Ile | p.L146I | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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