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Gene: UBB |
Gene summary for UBB |
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Gene information | Species | Human | Gene symbol | UBB | Gene ID | 7314 |
Gene name | ubiquitin B | |
Gene Alias | HEL-S-50 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P0CG47 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7314 | UBB | GSM4909277 | Human | Breast | Precancer | 1.09e-09 | 7.00e-01 | 0.0177 |
7314 | UBB | GSM4909280 | Human | Breast | Precancer | 1.03e-09 | 5.37e-01 | 0.0305 |
7314 | UBB | GSM4909286 | Human | Breast | IDC | 8.44e-08 | -1.29e-01 | 0.1081 |
7314 | UBB | GSM4909291 | Human | Breast | IDC | 1.56e-14 | 4.41e-01 | 0.1753 |
7314 | UBB | GSM4909293 | Human | Breast | IDC | 5.37e-09 | -1.82e-01 | 0.1581 |
7314 | UBB | GSM4909294 | Human | Breast | IDC | 9.65e-05 | 8.74e-02 | 0.2022 |
7314 | UBB | GSM4909295 | Human | Breast | IDC | 4.96e-04 | 3.37e-01 | 0.0898 |
7314 | UBB | GSM4909297 | Human | Breast | IDC | 1.21e-20 | 2.35e-01 | 0.1517 |
7314 | UBB | GSM4909298 | Human | Breast | IDC | 2.05e-14 | -3.92e-01 | 0.1551 |
7314 | UBB | GSM4909302 | Human | Breast | IDC | 2.15e-03 | -3.61e-01 | 0.1545 |
7314 | UBB | GSM4909305 | Human | Breast | IDC | 2.80e-02 | 1.82e-01 | 0.0436 |
7314 | UBB | GSM4909308 | Human | Breast | IDC | 7.35e-03 | 2.01e-01 | 0.158 |
7314 | UBB | GSM4909311 | Human | Breast | IDC | 7.54e-40 | -6.90e-01 | 0.1534 |
7314 | UBB | GSM4909312 | Human | Breast | IDC | 2.00e-11 | -4.56e-01 | 0.1552 |
7314 | UBB | GSM4909315 | Human | Breast | IDC | 7.81e-05 | -3.29e-01 | 0.21 |
7314 | UBB | GSM4909317 | Human | Breast | IDC | 3.60e-07 | 3.15e-01 | 0.1355 |
7314 | UBB | GSM4909319 | Human | Breast | IDC | 1.70e-47 | -5.26e-01 | 0.1563 |
7314 | UBB | GSM4909321 | Human | Breast | IDC | 9.23e-44 | 5.66e-01 | 0.1559 |
7314 | UBB | brca3 | Human | Breast | Precancer | 8.90e-08 | -1.48e-01 | -0.0263 |
7314 | UBB | NCCBC14 | Human | Breast | DCIS | 4.62e-06 | -3.06e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200124410 | Esophagus | HGIN | positive regulation of intrinsic apoptotic signaling pathway | 25/2587 | 58/18723 | 4.91e-08 | 2.75e-06 | 25 |
GO:007233127 | Esophagus | HGIN | signal transduction by p53 class mediator | 49/2587 | 163/18723 | 5.71e-08 | 3.06e-06 | 49 |
GO:200123519 | Esophagus | HGIN | positive regulation of apoptotic signaling pathway | 41/2587 | 126/18723 | 6.06e-08 | 3.22e-06 | 41 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:007099727 | Esophagus | HGIN | neuron death | 81/2587 | 361/18723 | 5.01e-06 | 1.61e-04 | 81 |
GO:007233220 | Esophagus | HGIN | intrinsic apoptotic signaling pathway by p53 class mediator | 26/2587 | 76/18723 | 5.43e-06 | 1.73e-04 | 26 |
GO:190179827 | Esophagus | HGIN | positive regulation of signal transduction by p53 class mediator | 13/2587 | 25/18723 | 6.62e-06 | 2.07e-04 | 13 |
GO:190121424 | Esophagus | HGIN | regulation of neuron death | 68/2587 | 319/18723 | 1.46e-04 | 2.91e-03 | 68 |
GO:19033228 | Esophagus | HGIN | positive regulation of protein modification by small protein conjugation or removal | 35/2587 | 138/18723 | 2.11e-04 | 3.88e-03 | 35 |
GO:190179627 | Esophagus | HGIN | regulation of signal transduction by p53 class mediator | 26/2587 | 93/18723 | 2.60e-04 | 4.55e-03 | 26 |
GO:003070517 | Esophagus | HGIN | cytoskeleton-dependent intracellular transport | 45/2587 | 195/18723 | 3.07e-04 | 5.15e-03 | 45 |
GO:00070518 | Esophagus | HGIN | spindle organization | 42/2587 | 184/18723 | 6.07e-04 | 8.49e-03 | 42 |
GO:190225320 | Esophagus | HGIN | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 11/2587 | 29/18723 | 1.08e-03 | 1.32e-02 | 11 |
GO:00109707 | Esophagus | HGIN | transport along microtubule | 35/2587 | 155/18723 | 2.01e-03 | 2.12e-02 | 35 |
GO:00313987 | Esophagus | HGIN | positive regulation of protein ubiquitination | 28/2587 | 119/18723 | 2.89e-03 | 2.81e-02 | 28 |
GO:00516542 | Esophagus | HGIN | establishment of mitochondrion localization | 10/2587 | 29/18723 | 4.07e-03 | 3.65e-02 | 10 |
GO:006145819 | Esophagus | HGIN | reproductive system development | 78/2587 | 427/18723 | 5.53e-03 | 4.52e-02 | 78 |
GO:00346432 | Esophagus | HGIN | establishment of mitochondrion localization, microtubule-mediated | 9/2587 | 26/18723 | 6.15e-03 | 4.92e-02 | 9 |
GO:00474972 | Esophagus | HGIN | mitochondrion transport along microtubule | 9/2587 | 26/18723 | 6.15e-03 | 4.92e-02 | 9 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0516718 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0516719 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0516723 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0516733 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBB | SNV | Missense_Mutation | c.70N>C | p.Glu24Gln | p.E24Q | P0CG47 | protein_coding | tolerated(0.2) | benign(0.047) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
UBB | SNV | Missense_Mutation | c.65N>T | p.Thr22Ile | p.T22I | P0CG47 | protein_coding | deleterious(0.01) | possibly_damaging(0.49) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UBB | SNV | Missense_Mutation | c.388N>T | p.Arg130Cys | p.R130C | P0CG47 | protein_coding | tolerated(0.07) | benign(0.198) | TCGA-AG-A01Y-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
UBB | SNV | Missense_Mutation | c.671N>A | p.Arg224His | p.R224H | P0CG47 | protein_coding | deleterious(0.04) | possibly_damaging(0.867) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UBB | SNV | Missense_Mutation | c.328N>A | p.Glu110Lys | p.E110K | P0CG47 | protein_coding | deleterious(0.02) | benign(0.268) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
UBB | SNV | Missense_Mutation | novel | c.355N>A | p.Leu119Ile | p.L119I | P0CG47 | protein_coding | deleterious(0.02) | possibly_damaging(0.645) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
UBB | SNV | Missense_Mutation | c.93G>T | p.Gln31His | p.Q31H | P0CG47 | protein_coding | tolerated(0.05) | benign(0.031) | TCGA-AX-A2H5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
UBB | SNV | Missense_Mutation | novel | c.179N>G | p.Asn60Ser | p.N60S | P0CG47 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBB | SNV | Missense_Mutation | novel | c.443N>A | p.Arg148His | p.R148H | P0CG47 | protein_coding | tolerated(0.08) | possibly_damaging(0.9) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBB | SNV | Missense_Mutation | novel | c.292N>G | p.Thr98Ala | p.T98A | P0CG47 | protein_coding | deleterious(0.01) | benign(0.13) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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