Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SPRED1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SPRED1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SPRED1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SPRED1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SPRED1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SPRED1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004001313 | Prostate | Tumor | negative regulation of locomotion | 94/3246 | 391/18723 | 4.20e-04 | 3.21e-03 | 94 |
GO:00107171 | Prostate | Tumor | regulation of epithelial to mesenchymal transition | 31/3246 | 99/18723 | 4.74e-04 | 3.54e-03 | 31 |
GO:003033613 | Prostate | Tumor | negative regulation of cell migration | 84/3246 | 344/18723 | 4.95e-04 | 3.66e-03 | 84 |
GO:003560112 | Prostate | Tumor | protein deacylation | 33/3246 | 112/18723 | 1.05e-03 | 6.77e-03 | 33 |
GO:00902871 | Prostate | Tumor | regulation of cellular response to growth factor stimulus | 74/3246 | 304/18723 | 1.13e-03 | 7.22e-03 | 74 |
GO:000647612 | Prostate | Tumor | protein deacetylation | 30/3246 | 101/18723 | 1.50e-03 | 9.27e-03 | 30 |
GO:009873211 | Prostate | Tumor | macromolecule deacylation | 33/3246 | 116/18723 | 2.00e-03 | 1.16e-02 | 33 |
GO:007037312 | Prostate | Tumor | negative regulation of ERK1 and ERK2 cascade | 24/3246 | 78/18723 | 2.56e-03 | 1.42e-02 | 24 |
GO:00308571 | Prostate | Tumor | negative regulation of epithelial cell differentiation | 17/3246 | 49/18723 | 2.61e-03 | 1.43e-02 | 17 |
GO:00108011 | Prostate | Tumor | negative regulation of peptidyl-threonine phosphorylation | 9/3246 | 20/18723 | 3.73e-03 | 1.91e-02 | 9 |
GO:007037113 | Prostate | Tumor | ERK1 and ERK2 cascade | 76/3246 | 330/18723 | 4.66e-03 | 2.29e-02 | 76 |
GO:009009212 | Prostate | Tumor | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 61/3246 | 256/18723 | 4.84e-03 | 2.37e-02 | 61 |
GO:00703061 | Prostate | Tumor | lens fiber cell differentiation | 13/3246 | 36/18723 | 5.47e-03 | 2.60e-02 | 13 |
GO:190134212 | Prostate | Tumor | regulation of vasculature development | 79/3246 | 348/18723 | 5.84e-03 | 2.71e-02 | 79 |
GO:004353412 | Prostate | Tumor | blood vessel endothelial cell migration | 44/3246 | 176/18723 | 6.27e-03 | 2.89e-02 | 44 |
GO:004576512 | Prostate | Tumor | regulation of angiogenesis | 77/3246 | 342/18723 | 7.92e-03 | 3.52e-02 | 77 |
GO:00305122 | Prostate | Tumor | negative regulation of transforming growth factor beta receptor signaling pathway | 23/3246 | 81/18723 | 9.13e-03 | 3.93e-02 | 23 |
GO:00016541 | Prostate | Tumor | eye development | 82/3246 | 371/18723 | 1.02e-02 | 4.27e-02 | 82 |
GO:0010799 | Prostate | Tumor | regulation of peptidyl-threonine phosphorylation | 15/3246 | 47/18723 | 1.07e-02 | 4.45e-02 | 15 |
GO:200102212 | Prostate | Tumor | positive regulation of response to DNA damage stimulus | 28/3246 | 105/18723 | 1.08e-02 | 4.47e-02 | 28 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPRED1 | SNV | Missense_Mutation | | c.337N>A | p.Asp113Asn | p.D113N | Q7Z699 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SPRED1 | SNV | Missense_Mutation | | c.279G>C | p.Lys93Asn | p.K93N | Q7Z699 | protein_coding | deleterious(0.02) | probably_damaging(0.957) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
SPRED1 | SNV | Missense_Mutation | novel | c.140N>C | p.Val47Ala | p.V47A | Q7Z699 | protein_coding | tolerated(0.12) | benign(0.014) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
SPRED1 | SNV | Missense_Mutation | | c.970A>G | p.Lys324Glu | p.K324E | Q7Z699 | protein_coding | tolerated(0.12) | benign(0.444) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPRED1 | SNV | Missense_Mutation | novel | c.506N>C | p.Arg169Thr | p.R169T | Q7Z699 | protein_coding | tolerated(0.5) | benign(0.057) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | | SD |
SPRED1 | SNV | Missense_Mutation | rs200142785 | c.565N>A | p.Gln189Lys | p.Q189K | Q7Z699 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPRED1 | SNV | Missense_Mutation | novel | c.752N>A | p.Arg251Gln | p.R251Q | Q7Z699 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPRED1 | SNV | Missense_Mutation | | c.397N>A | p.Glu133Lys | p.E133K | Q7Z699 | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SPRED1 | SNV | Missense_Mutation | novel | c.1175N>T | p.Ser392Leu | p.S392L | Q7Z699 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
SPRED1 | SNV | Missense_Mutation | novel | c.161N>A | p.Gly54Asp | p.G54D | Q7Z699 | protein_coding | deleterious(0.02) | benign(0.089) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |