Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SPIDR_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SPIDR_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SPIDR_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SPIDR_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SPIDR_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/SPIDR_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SPIDR_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SPIDR_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SPIDR_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SPIDR_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SPIDR_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00345025 | Skin | cSCC | protein localization to chromosome | 44/4864 | 92/18723 | 5.27e-06 | 7.64e-05 | 44 |
GO:2001020111 | Skin | cSCC | regulation of response to DNA damage stimulus | 87/4864 | 219/18723 | 5.38e-06 | 7.75e-05 | 87 |
GO:005105419 | Skin | cSCC | positive regulation of DNA metabolic process | 80/4864 | 201/18723 | 1.16e-05 | 1.50e-04 | 80 |
GO:00701997 | Skin | cSCC | establishment of protein localization to chromosome | 15/4864 | 25/18723 | 3.36e-04 | 2.67e-03 | 15 |
GO:00063025 | Skin | cSCC | double-strand break repair | 89/4864 | 251/18723 | 5.23e-04 | 3.92e-03 | 89 |
GO:00062827 | Skin | cSCC | regulation of DNA repair | 47/4864 | 130/18723 | 6.52e-03 | 3.17e-02 | 47 |
GO:0097305112 | Skin | cSCC | response to alcohol | 83/4864 | 253/18723 | 8.81e-03 | 4.05e-02 | 83 |
GO:00432546 | Stomach | GC | regulation of protein-containing complex assembly | 58/1159 | 428/18723 | 1.48e-08 | 1.32e-06 | 58 |
GO:00313346 | Stomach | GC | positive regulation of protein-containing complex assembly | 39/1159 | 237/18723 | 2.00e-08 | 1.63e-06 | 39 |
GO:00712416 | Stomach | GC | cellular response to inorganic substance | 30/1159 | 226/18723 | 6.50e-05 | 1.46e-03 | 30 |
GO:0009314 | Stomach | GC | response to radiation | 47/1159 | 456/18723 | 4.21e-04 | 6.33e-03 | 47 |
GO:00725946 | Stomach | GC | establishment of protein localization to organelle | 43/1159 | 422/18723 | 9.14e-04 | 1.11e-02 | 43 |
GO:00973055 | Stomach | GC | response to alcohol | 28/1159 | 253/18723 | 2.09e-03 | 2.09e-02 | 28 |
GO:00712144 | Stomach | GC | cellular response to abiotic stimulus | 34/1159 | 331/18723 | 2.62e-03 | 2.45e-02 | 34 |
GO:01040044 | Stomach | GC | cellular response to environmental stimulus | 34/1159 | 331/18723 | 2.62e-03 | 2.45e-02 | 34 |
GO:0071479 | Stomach | GC | cellular response to ionizing radiation | 11/1159 | 72/18723 | 4.54e-03 | 3.69e-02 | 11 |
GO:00702024 | Stomach | GC | regulation of establishment of protein localization to chromosome | 4/1159 | 12/18723 | 4.84e-03 | 3.87e-02 | 4 |
GO:004325411 | Stomach | CAG with IM | regulation of protein-containing complex assembly | 56/1050 | 428/18723 | 2.91e-09 | 3.23e-07 | 56 |
GO:003133411 | Stomach | CAG with IM | positive regulation of protein-containing complex assembly | 37/1050 | 237/18723 | 1.48e-08 | 1.23e-06 | 37 |
GO:00093141 | Stomach | CAG with IM | response to radiation | 44/1050 | 456/18723 | 3.24e-04 | 5.39e-03 | 44 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPIDR | SNV | Missense_Mutation | | c.715N>G | p.Gln239Glu | p.Q239E | Q14159 | protein_coding | tolerated(0.14) | benign(0.199) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
SPIDR | SNV | Missense_Mutation | novel | c.278N>T | p.Thr93Ile | p.T93I | Q14159 | protein_coding | tolerated(0.09) | benign(0.089) | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
SPIDR | SNV | Missense_Mutation | novel | c.1010N>A | p.Gly337Glu | p.G337E | Q14159 | protein_coding | tolerated(0.46) | benign(0.332) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SPIDR | SNV | Missense_Mutation | novel | c.319G>A | p.Asp107Asn | p.D107N | Q14159 | protein_coding | tolerated(0.11) | probably_damaging(0.996) | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SPIDR | SNV | Missense_Mutation | | c.1955N>G | p.Thr652Arg | p.T652R | Q14159 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPIDR | SNV | Missense_Mutation | rs777561291 | c.2068N>T | p.Leu690Phe | p.L690F | Q14159 | protein_coding | tolerated(0.06) | probably_damaging(0.967) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SPIDR | SNV | Missense_Mutation | rs782141616 | c.1045G>A | p.Ala349Thr | p.A349T | Q14159 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPIDR | SNV | Missense_Mutation | | c.1127N>A | p.Cys376Tyr | p.C376Y | Q14159 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-C8-A12Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPIDR | SNV | Missense_Mutation | rs375968682 | c.2654N>C | p.Cys885Ser | p.C885S | Q14159 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SPIDR | insertion | Frame_Shift_Ins | novel | c.2740_2741insTT | p.Glu914ValfsTer61 | p.E914Vfs*61 | Q14159 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |