![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SIPA1 |
Gene summary for SIPA1 |
![]() |
Gene information | Species | Human | Gene symbol | SIPA1 | Gene ID | 6494 |
Gene name | signal-induced proliferation-associated 1 | |
Gene Alias | SPA1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | Q96FS4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6494 | SIPA1 | LZE5T | Human | Esophagus | ESCC | 1.02e-05 | 3.65e-01 | 0.0514 |
6494 | SIPA1 | LZE20T | Human | Esophagus | ESCC | 1.94e-21 | 7.57e-01 | 0.0662 |
6494 | SIPA1 | LZE22T | Human | Esophagus | ESCC | 3.76e-04 | 4.15e-01 | 0.068 |
6494 | SIPA1 | LZE24T | Human | Esophagus | ESCC | 3.32e-33 | 7.78e-01 | 0.0596 |
6494 | SIPA1 | P1T-E | Human | Esophagus | ESCC | 8.04e-17 | 6.33e-01 | 0.0875 |
6494 | SIPA1 | P2T-E | Human | Esophagus | ESCC | 8.98e-11 | 1.34e-01 | 0.1177 |
6494 | SIPA1 | P4T-E | Human | Esophagus | ESCC | 3.70e-17 | 4.04e-01 | 0.1323 |
6494 | SIPA1 | P5T-E | Human | Esophagus | ESCC | 5.61e-14 | 2.49e-01 | 0.1327 |
6494 | SIPA1 | P8T-E | Human | Esophagus | ESCC | 3.34e-50 | 1.04e+00 | 0.0889 |
6494 | SIPA1 | P9T-E | Human | Esophagus | ESCC | 5.26e-04 | 1.25e-01 | 0.1131 |
6494 | SIPA1 | P10T-E | Human | Esophagus | ESCC | 6.95e-03 | 6.97e-02 | 0.116 |
6494 | SIPA1 | P11T-E | Human | Esophagus | ESCC | 3.49e-06 | 2.16e-01 | 0.1426 |
6494 | SIPA1 | P12T-E | Human | Esophagus | ESCC | 1.74e-03 | 1.25e-01 | 0.1122 |
6494 | SIPA1 | P15T-E | Human | Esophagus | ESCC | 4.50e-21 | 4.31e-01 | 0.1149 |
6494 | SIPA1 | P16T-E | Human | Esophagus | ESCC | 8.64e-19 | 3.91e-01 | 0.1153 |
6494 | SIPA1 | P17T-E | Human | Esophagus | ESCC | 4.36e-13 | 5.10e-01 | 0.1278 |
6494 | SIPA1 | P19T-E | Human | Esophagus | ESCC | 3.01e-06 | 4.41e-01 | 0.1662 |
6494 | SIPA1 | P20T-E | Human | Esophagus | ESCC | 6.05e-24 | 4.92e-01 | 0.1124 |
6494 | SIPA1 | P21T-E | Human | Esophagus | ESCC | 2.67e-07 | 2.29e-01 | 0.1617 |
6494 | SIPA1 | P23T-E | Human | Esophagus | ESCC | 4.43e-31 | 7.70e-01 | 0.108 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016541 | Prostate | Tumor | eye development | 82/3246 | 371/18723 | 1.02e-02 | 4.27e-02 | 82 |
GO:005080711 | Prostate | Tumor | regulation of synapse organization | 50/3246 | 211/18723 | 1.11e-02 | 4.56e-02 | 50 |
GO:006156416 | Skin | AK | axon development | 91/1910 | 467/18723 | 8.60e-10 | 8.63e-08 | 91 |
GO:000740916 | Skin | AK | axonogenesis | 80/1910 | 418/18723 | 2.07e-08 | 1.19e-06 | 80 |
GO:001097517 | Skin | AK | regulation of neuron projection development | 79/1910 | 445/18723 | 6.49e-07 | 2.23e-05 | 79 |
GO:00609968 | Skin | AK | dendritic spine development | 27/1910 | 99/18723 | 1.34e-06 | 4.15e-05 | 27 |
GO:001635817 | Skin | AK | dendrite development | 49/1910 | 243/18723 | 2.42e-06 | 6.72e-05 | 49 |
GO:00508088 | Skin | AK | synapse organization | 71/1910 | 426/18723 | 2.21e-05 | 4.07e-04 | 71 |
GO:00610016 | Skin | AK | regulation of dendritic spine morphogenesis | 15/1910 | 47/18723 | 4.05e-05 | 6.58e-04 | 15 |
GO:010602710 | Skin | AK | neuron projection organization | 23/1910 | 93/18723 | 4.44e-05 | 7.03e-04 | 23 |
GO:00970619 | Skin | AK | dendritic spine organization | 21/1910 | 84/18723 | 7.93e-05 | 1.09e-03 | 21 |
GO:00609975 | Skin | AK | dendritic spine morphogenesis | 17/1910 | 61/18723 | 8.79e-05 | 1.20e-03 | 17 |
GO:00488138 | Skin | AK | dendrite morphogenesis | 30/1910 | 146/18723 | 1.44e-04 | 1.73e-03 | 30 |
GO:00991753 | Skin | AK | regulation of postsynapse organization | 21/1910 | 90/18723 | 2.27e-04 | 2.51e-03 | 21 |
GO:00507734 | Skin | AK | regulation of dendrite development | 23/1910 | 103/18723 | 2.34e-04 | 2.58e-03 | 23 |
GO:00991737 | Skin | AK | postsynapse organization | 32/1910 | 168/18723 | 3.77e-04 | 3.65e-03 | 32 |
GO:003153219 | Skin | AK | actin cytoskeleton reorganization | 23/1910 | 107/18723 | 4.20e-04 | 4.00e-03 | 23 |
GO:00480134 | Skin | AK | ephrin receptor signaling pathway | 14/1910 | 51/18723 | 4.29e-04 | 4.05e-03 | 14 |
GO:00508031 | Skin | AK | regulation of synapse structure or activity | 38/1910 | 218/18723 | 7.06e-04 | 6.01e-03 | 38 |
GO:00508073 | Skin | AK | regulation of synapse organization | 37/1910 | 211/18723 | 7.35e-04 | 6.20e-03 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0467042 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
hsa0467052 | Liver | HCC | Leukocyte transendothelial migration | 68/4020 | 114/8465 | 5.79e-03 | 1.64e-02 | 9.15e-03 | 68 |
hsa0467030 | Oral cavity | OSCC | Leukocyte transendothelial migration | 63/3704 | 114/8465 | 8.46e-03 | 1.96e-02 | 9.95e-03 | 63 |
hsa0401518 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
hsa04670113 | Oral cavity | OSCC | Leukocyte transendothelial migration | 63/3704 | 114/8465 | 8.46e-03 | 1.96e-02 | 9.95e-03 | 63 |
hsa0401519 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIPA1 | SNV | Missense_Mutation | rs747257834 | c.2644N>A | p.Pro882Thr | p.P882T | Q96FS4 | protein_coding | tolerated(0.07) | benign(0.025) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
SIPA1 | SNV | Missense_Mutation | c.724N>A | p.Ala242Thr | p.A242T | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | c.3118N>C | p.Asp1040His | p.D1040H | Q96FS4 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.995) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | |
SIPA1 | SNV | Missense_Mutation | c.3120N>A | p.Asp1040Glu | p.D1040E | Q96FS4 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.935) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | |
SIPA1 | SNV | Missense_Mutation | novel | c.1247N>G | p.Pro416Arg | p.P416R | Q96FS4 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SIPA1 | insertion | In_Frame_Ins | novel | c.726_727insCCC | p.Ala242_Val243insPro | p.A242_V243insP | Q96FS4 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SIPA1 | SNV | Missense_Mutation | c.2530N>G | p.Leu844Val | p.L844V | Q96FS4 | protein_coding | tolerated(0.15) | benign(0.025) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SIPA1 | SNV | Missense_Mutation | c.803C>T | p.Thr268Met | p.T268M | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | c.778N>G | p.Ser260Gly | p.S260G | Q96FS4 | protein_coding | deleterious(0.02) | benign(0.281) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIPA1 | SNV | Missense_Mutation | novel | c.2713N>T | p.Arg905Cys | p.R905C | Q96FS4 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |