Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RICTOR_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RICTOR_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RICTOR_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RICTOR_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RICTOR_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RICTOR_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RICTOR_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RICTOR_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003227123 | Lung | AAH | regulation of protein polymerization | 17/613 | 233/18723 | 1.79e-03 | 4.22e-02 | 17 |
GO:003133422 | Lung | AAH | positive regulation of protein-containing complex assembly | 17/613 | 237/18723 | 2.15e-03 | 4.66e-02 | 17 |
GO:000815423 | Lung | AAH | actin polymerization or depolymerization | 16/613 | 218/18723 | 2.27e-03 | 4.84e-02 | 16 |
GO:003001031 | Lung | MIAC | establishment of cell polarity | 27/967 | 143/18723 | 4.16e-09 | 4.27e-06 | 27 |
GO:000716332 | Lung | MIAC | establishment or maintenance of cell polarity | 34/967 | 218/18723 | 7.70e-09 | 4.94e-06 | 34 |
GO:000701533 | Lung | MIAC | actin filament organization | 50/967 | 442/18723 | 1.64e-07 | 3.81e-05 | 50 |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:001810521 | Lung | MIAC | peptidyl-serine phosphorylation | 37/967 | 315/18723 | 2.73e-06 | 3.12e-04 | 37 |
GO:005125823 | Lung | MIAC | protein polymerization | 35/967 | 297/18723 | 4.69e-06 | 4.81e-04 | 35 |
GO:190290333 | Lung | MIAC | regulation of supramolecular fiber organization | 41/967 | 383/18723 | 8.33e-06 | 7.24e-04 | 41 |
GO:003227132 | Lung | MIAC | regulation of protein polymerization | 29/967 | 233/18723 | 1.06e-05 | 8.86e-04 | 29 |
GO:004325423 | Lung | MIAC | regulation of protein-containing complex assembly | 44/967 | 428/18723 | 1.11e-05 | 9.00e-04 | 44 |
GO:001820921 | Lung | MIAC | peptidyl-serine modification | 37/967 | 338/18723 | 1.38e-05 | 9.86e-04 | 37 |
GO:011005332 | Lung | MIAC | regulation of actin filament organization | 32/967 | 278/18723 | 1.91e-05 | 1.27e-03 | 32 |
GO:003297032 | Lung | MIAC | regulation of actin filament-based process | 41/967 | 397/18723 | 1.96e-05 | 1.28e-03 | 41 |
GO:003287831 | Lung | MIAC | regulation of establishment or maintenance of cell polarity | 8/967 | 25/18723 | 2.42e-05 | 1.53e-03 | 8 |
GO:003153231 | Lung | MIAC | actin cytoskeleton reorganization | 17/967 | 107/18723 | 3.31e-05 | 1.91e-03 | 17 |
GO:003133432 | Lung | MIAC | positive regulation of protein-containing complex assembly | 28/967 | 237/18723 | 3.91e-05 | 2.08e-03 | 28 |
GO:003295632 | Lung | MIAC | regulation of actin cytoskeleton organization | 37/967 | 358/18723 | 4.85e-05 | 2.49e-03 | 37 |
GO:200011431 | Lung | MIAC | regulation of establishment of cell polarity | 7/967 | 22/18723 | 8.25e-05 | 3.75e-03 | 7 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RICTOR | SNV | Missense_Mutation | novel | c.4426C>T | p.Pro1476Ser | p.P1476S | Q6R327 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RICTOR | SNV | Missense_Mutation | novel | c.1259N>T | p.Ser420Leu | p.S420L | Q6R327 | protein_coding | deleterious(0.04) | benign(0.055) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
RICTOR | SNV | Missense_Mutation | | c.2270N>T | p.Thr757Ile | p.T757I | Q6R327 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RICTOR | SNV | Missense_Mutation | | c.4292N>T | p.Ser1431Phe | p.S1431F | Q6R327 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RICTOR | SNV | Missense_Mutation | novel | c.604N>T | p.Val202Leu | p.V202L | Q6R327 | protein_coding | tolerated(0.1) | benign(0.028) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RICTOR | SNV | Missense_Mutation | | c.545N>C | p.Arg182Thr | p.R182T | Q6R327 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RICTOR | SNV | Missense_Mutation | | c.3665N>T | p.Thr1222Ile | p.T1222I | Q6R327 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RICTOR | SNV | Missense_Mutation | rs778788008 | c.301G>A | p.Ala101Thr | p.A101T | Q6R327 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
RICTOR | SNV | Missense_Mutation | | c.4882N>A | p.Asp1628Asn | p.D1628N | Q6R327 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RICTOR | SNV | Missense_Mutation | | c.2425N>T | p.Leu809Phe | p.L809F | Q6R327 | protein_coding | deleterious(0.01) | possibly_damaging(0.747) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |