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Gene: PCM1 |
Gene summary for PCM1 |
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Gene information | Species | Human | Gene symbol | PCM1 | Gene ID | 5108 |
Gene name | pericentriolar material 1 | |
Gene Alias | PTC4 | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B9EIS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5108 | PCM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.29e-21 | -5.64e-01 | 0.0155 |
5108 | PCM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.31e-06 | -4.64e-01 | -0.1808 |
5108 | PCM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.10e-02 | -6.85e-01 | -0.2196 |
5108 | PCM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.61e-09 | -4.79e-01 | -0.1207 |
5108 | PCM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.46e-03 | -3.87e-01 | -0.1526 |
5108 | PCM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.36e-03 | -3.16e-01 | -0.1464 |
5108 | PCM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.89e-02 | -2.80e-01 | -0.1001 |
5108 | PCM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.01e-03 | -3.63e-01 | -0.059 |
5108 | PCM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.15e-04 | -6.17e-01 | -0.2061 |
5108 | PCM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.23e-03 | -7.35e-01 | -0.1462 |
5108 | PCM1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.27e-03 | -4.93e-01 | -0.0179 |
5108 | PCM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.84e-06 | -3.92e-01 | 0.096 |
5108 | PCM1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.55e-02 | -3.90e-01 | 0.0338 |
5108 | PCM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.90e-08 | -3.42e-01 | 0.0674 |
5108 | PCM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.92e-19 | -5.83e-01 | 0.3859 |
5108 | PCM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.66e-12 | -4.21e-01 | 0.3005 |
5108 | PCM1 | A015-C-203 | Human | Colorectum | FAP | 1.90e-23 | -6.10e-02 | -0.1294 |
5108 | PCM1 | A014-C-040 | Human | Colorectum | FAP | 3.97e-03 | -7.61e-02 | -0.1184 |
5108 | PCM1 | A002-C-201 | Human | Colorectum | FAP | 4.03e-11 | -1.13e-01 | 0.0324 |
5108 | PCM1 | A001-C-119 | Human | Colorectum | FAP | 5.81e-05 | 9.19e-02 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003150316 | Thyroid | ATC | protein-containing complex localization | 108/6293 | 220/18723 | 1.33e-06 | 1.69e-05 | 108 |
GO:005196014 | Thyroid | ATC | regulation of nervous system development | 195/6293 | 443/18723 | 2.62e-06 | 3.06e-05 | 195 |
GO:009872722 | Thyroid | ATC | maintenance of cell number | 70/6293 | 134/18723 | 6.45e-06 | 6.69e-05 | 70 |
GO:001982722 | Thyroid | ATC | stem cell population maintenance | 67/6293 | 131/18723 | 2.48e-05 | 2.16e-04 | 67 |
GO:003112215 | Thyroid | ATC | cytoplasmic microtubule organization | 34/6293 | 56/18723 | 2.92e-05 | 2.45e-04 | 34 |
GO:009911112 | Thyroid | ATC | microtubule-based transport | 91/6293 | 190/18723 | 2.97e-05 | 2.48e-04 | 91 |
GO:003090015 | Thyroid | ATC | forebrain development | 164/6293 | 379/18723 | 4.85e-05 | 3.87e-04 | 164 |
GO:003102311 | Thyroid | ATC | microtubule organizing center organization | 71/6293 | 143/18723 | 5.11e-05 | 3.99e-04 | 71 |
GO:000709811 | Thyroid | ATC | centrosome cycle | 65/6293 | 130/18723 | 7.95e-05 | 5.97e-04 | 65 |
GO:00107216 | Thyroid | ATC | negative regulation of cell development | 76/6293 | 180/18723 | 9.50e-03 | 3.49e-02 | 76 |
GO:000709712 | Thyroid | ATC | nuclear migration | 12/6293 | 20/18723 | 1.39e-02 | 4.81e-02 | 12 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCM1 | SNV | Missense_Mutation | rs374857257 | c.5357N>G | p.Ser1786Cys | p.S1786C | Q15154 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PCM1 | SNV | Missense_Mutation | novel | c.1067N>A | p.Ser356Tyr | p.S356Y | Q15154 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCM1 | SNV | Missense_Mutation | c.3985N>C | p.Lys1329Gln | p.K1329Q | Q15154 | protein_coding | tolerated(0.46) | benign(0.077) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
PCM1 | insertion | Frame_Shift_Ins | novel | c.142_143insG | p.Asn48ArgfsTer2 | p.N48Rfs*2 | Q15154 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
PCM1 | insertion | Nonsense_Mutation | novel | c.1270_1271insTCTAGGCTACTTATA | p.His424delinsLeuTerAlaThrTyrAsn | p.H424delinsL*ATYN | Q15154 | protein_coding | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | CR | |||
PCM1 | insertion | Frame_Shift_Ins | novel | c.2643_2644insGGGCAGATCATGAGGTCAGGTATTCA | p.Arg882GlyfsTer26 | p.R882Gfs*26 | Q15154 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
PCM1 | SNV | Missense_Mutation | rs768119487 | c.6034N>G | p.Thr2012Ala | p.T2012A | Q15154 | protein_coding | tolerated(0.59) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PCM1 | SNV | Missense_Mutation | c.1435N>A | p.Glu479Lys | p.E479K | Q15154 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PCM1 | SNV | Missense_Mutation | c.4408G>C | p.Asp1470His | p.D1470H | Q15154 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PCM1 | SNV | Missense_Mutation | novel | c.3398C>T | p.Ser1133Leu | p.S1133L | Q15154 | protein_coding | deleterious(0) | benign(0.225) | TCGA-VS-A954-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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