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Gene: NUCKS1 |
Gene summary for NUCKS1 |
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Gene information | Species | Human | Gene symbol | NUCKS1 | Gene ID | 64710 |
Gene name | nuclear casein kinase and cyclin dependent kinase substrate 1 | |
Gene Alias | JC7 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9H1E3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64710 | NUCKS1 | GSM4909281 | Human | Breast | IDC | 5.20e-19 | 5.54e-01 | 0.21 |
64710 | NUCKS1 | GSM4909282 | Human | Breast | IDC | 4.09e-26 | 5.97e-01 | -0.0288 |
64710 | NUCKS1 | GSM4909285 | Human | Breast | IDC | 7.37e-61 | 8.52e-01 | 0.21 |
64710 | NUCKS1 | GSM4909287 | Human | Breast | IDC | 1.30e-37 | 6.41e-01 | 0.2057 |
64710 | NUCKS1 | GSM4909290 | Human | Breast | IDC | 2.50e-23 | 6.22e-01 | 0.2096 |
64710 | NUCKS1 | GSM4909291 | Human | Breast | IDC | 2.01e-08 | 4.09e-01 | 0.1753 |
64710 | NUCKS1 | GSM4909293 | Human | Breast | IDC | 4.36e-86 | 9.29e-01 | 0.1581 |
64710 | NUCKS1 | GSM4909294 | Human | Breast | IDC | 4.64e-14 | 1.97e-01 | 0.2022 |
64710 | NUCKS1 | GSM4909296 | Human | Breast | IDC | 8.72e-18 | 1.79e-01 | 0.1524 |
64710 | NUCKS1 | GSM4909297 | Human | Breast | IDC | 8.69e-31 | 1.54e-01 | 0.1517 |
64710 | NUCKS1 | GSM4909298 | Human | Breast | IDC | 3.24e-27 | 6.20e-01 | 0.1551 |
64710 | NUCKS1 | GSM4909299 | Human | Breast | IDC | 5.41e-03 | 2.96e-01 | 0.035 |
64710 | NUCKS1 | GSM4909301 | Human | Breast | IDC | 1.51e-13 | 4.03e-01 | 0.1577 |
64710 | NUCKS1 | GSM4909302 | Human | Breast | IDC | 5.74e-26 | 4.87e-01 | 0.1545 |
64710 | NUCKS1 | GSM4909305 | Human | Breast | IDC | 3.64e-04 | 3.29e-01 | 0.0436 |
64710 | NUCKS1 | GSM4909306 | Human | Breast | IDC | 2.25e-26 | 5.82e-01 | 0.1564 |
64710 | NUCKS1 | GSM4909307 | Human | Breast | IDC | 5.99e-25 | 5.58e-01 | 0.1569 |
64710 | NUCKS1 | GSM4909308 | Human | Breast | IDC | 5.29e-19 | 5.32e-01 | 0.158 |
64710 | NUCKS1 | GSM4909309 | Human | Breast | IDC | 2.55e-12 | 3.24e-01 | 0.0483 |
64710 | NUCKS1 | GSM4909311 | Human | Breast | IDC | 3.19e-44 | -1.18e-01 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00714788 | Oral cavity | OSCC | cellular response to radiation | 109/7305 | 186/18723 | 4.54e-08 | 8.45e-07 | 109 |
GO:00518176 | Oral cavity | OSCC | modulation of process of other organism involved in symbiotic interaction | 54/7305 | 81/18723 | 4.22e-07 | 6.25e-06 | 54 |
GO:003286916 | Oral cavity | OSCC | cellular response to insulin stimulus | 114/7305 | 203/18723 | 5.07e-07 | 7.41e-06 | 114 |
GO:007147917 | Oral cavity | OSCC | cellular response to ionizing radiation | 49/7305 | 72/18723 | 5.59e-07 | 8.13e-06 | 49 |
GO:007137510 | Oral cavity | OSCC | cellular response to peptide hormone stimulus | 153/7305 | 290/18723 | 1.23e-06 | 1.63e-05 | 153 |
GO:004343419 | Oral cavity | OSCC | response to peptide hormone | 208/7305 | 414/18723 | 1.83e-06 | 2.35e-05 | 208 |
GO:00190833 | Oral cavity | OSCC | viral transcription | 36/7305 | 50/18723 | 2.26e-06 | 2.87e-05 | 36 |
GO:00358218 | Oral cavity | OSCC | modulation of process of other organism | 64/7305 | 106/18723 | 6.70e-06 | 7.36e-05 | 64 |
GO:003286816 | Oral cavity | OSCC | response to insulin | 138/7305 | 264/18723 | 7.54e-06 | 8.15e-05 | 138 |
GO:00063023 | Oral cavity | OSCC | double-strand break repair | 132/7305 | 251/18723 | 7.93e-06 | 8.52e-05 | 132 |
GO:00518517 | Oral cavity | OSCC | modulation by host of symbiont process | 40/7305 | 60/18723 | 1.32e-05 | 1.33e-04 | 40 |
GO:00062611 | Oral cavity | OSCC | DNA-dependent DNA replication | 84/7305 | 151/18723 | 2.46e-05 | 2.30e-04 | 84 |
GO:00082868 | Oral cavity | OSCC | insulin receptor signaling pathway | 67/7305 | 116/18723 | 3.23e-05 | 2.91e-04 | 67 |
GO:00062753 | Oral cavity | OSCC | regulation of DNA replication | 62/7305 | 107/18723 | 5.49e-05 | 4.54e-04 | 62 |
GO:00517029 | Oral cavity | OSCC | biological process involved in interaction with symbiont | 54/7305 | 94/18723 | 2.20e-04 | 1.44e-03 | 54 |
GO:19052141 | Oral cavity | OSCC | regulation of RNA binding | 11/7305 | 12/18723 | 2.45e-04 | 1.57e-03 | 11 |
GO:00439223 | Oral cavity | OSCC | negative regulation by host of viral transcription | 12/7305 | 14/18723 | 4.62e-04 | 2.76e-03 | 12 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
GO:000167816 | Oral cavity | OSCC | cellular glucose homeostasis | 88/7305 | 172/18723 | 7.74e-04 | 4.22e-03 | 88 |
GO:00447947 | Oral cavity | OSCC | positive regulation by host of viral process | 11/7305 | 13/18723 | 1.02e-03 | 5.29e-03 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUCKS1 | SNV | Missense_Mutation | c.256C>T | p.His86Tyr | p.H86Y | Q9H1E3 | protein_coding | tolerated(0.46) | benign(0.091) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
NUCKS1 | SNV | Missense_Mutation | rs771629435 | c.635C>T | p.Pro212Leu | p.P212L | Q9H1E3 | protein_coding | tolerated(0.29) | benign(0.061) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
NUCKS1 | SNV | Missense_Mutation | rs754971187 | c.274N>A | p.Gln92Lys | p.Q92K | Q9H1E3 | protein_coding | tolerated(1) | benign(0.444) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.218C>A | p.Ser73Tyr | p.S73Y | Q9H1E3 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | rs762593780 | c.89N>T | p.Ser30Leu | p.S30L | Q9H1E3 | protein_coding | tolerated(0.15) | possibly_damaging(0.572) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NUCKS1 | SNV | Missense_Mutation | rs551812416 | c.572N>A | p.Arg191His | p.R191H | Q9H1E3 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.295N>A | p.Ala99Thr | p.A99T | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | c.98N>T | p.Pro33Leu | p.P33L | Q9H1E3 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NUCKS1 | SNV | Missense_Mutation | rs758268939 | c.446N>T | p.Ser149Leu | p.S149L | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.343N>A | p.Glu115Lys | p.E115K | Q9H1E3 | protein_coding | tolerated(0.1) | possibly_damaging(0.452) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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