Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/NOL3_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NOL3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NOL3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NOL3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NOL3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516517 | Liver | Cirrhotic | maintenance of location in cell | 76/4634 | 214/18723 | 2.66e-04 | 2.37e-03 | 76 |
GO:00002454 | Liver | Cirrhotic | spliceosomal complex assembly | 34/4634 | 79/18723 | 2.78e-04 | 2.46e-03 | 34 |
GO:0038061 | Liver | Cirrhotic | NIK/NF-kappaB signaling | 54/4634 | 143/18723 | 3.64e-04 | 3.07e-03 | 54 |
GO:00714563 | Liver | Cirrhotic | cellular response to hypoxia | 56/4634 | 151/18723 | 4.86e-04 | 3.90e-03 | 56 |
GO:00362946 | Liver | Cirrhotic | cellular response to decreased oxygen levels | 59/4634 | 161/18723 | 4.98e-04 | 3.98e-03 | 59 |
GO:00713566 | Liver | Cirrhotic | cellular response to tumor necrosis factor | 79/4634 | 229/18723 | 5.68e-04 | 4.45e-03 | 79 |
GO:19004077 | Liver | Cirrhotic | regulation of cellular response to oxidative stress | 36/4634 | 89/18723 | 7.79e-04 | 5.73e-03 | 36 |
GO:19021083 | Liver | Cirrhotic | regulation of mitochondrial membrane permeability involved in apoptotic process | 21/4634 | 45/18723 | 1.14e-03 | 7.76e-03 | 21 |
GO:1903317 | Liver | Cirrhotic | regulation of protein maturation | 28/4634 | 67/18723 | 1.60e-03 | 1.04e-02 | 28 |
GO:00108236 | Liver | Cirrhotic | negative regulation of mitochondrion organization | 22/4634 | 49/18723 | 1.64e-03 | 1.05e-02 | 22 |
GO:00487711 | Liver | Cirrhotic | tissue remodeling | 60/4634 | 175/18723 | 2.86e-03 | 1.65e-02 | 60 |
GO:0070613 | Liver | Cirrhotic | regulation of protein processing | 26/4634 | 65/18723 | 4.73e-03 | 2.48e-02 | 26 |
GO:00018366 | Liver | Cirrhotic | release of cytochrome c from mitochondria | 24/4634 | 59/18723 | 5.06e-03 | 2.62e-02 | 24 |
GO:0010955 | Liver | Cirrhotic | negative regulation of protein processing | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
GO:1903318 | Liver | Cirrhotic | negative regulation of protein maturation | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
GO:19032027 | Liver | Cirrhotic | negative regulation of oxidative stress-induced cell death | 22/4634 | 53/18723 | 5.36e-03 | 2.73e-02 | 22 |
GO:19028827 | Liver | Cirrhotic | regulation of response to oxidative stress | 36/4634 | 98/18723 | 5.44e-03 | 2.77e-02 | 36 |
GO:00063762 | Liver | Cirrhotic | mRNA splice site selection | 20/4634 | 49/18723 | 9.60e-03 | 4.35e-02 | 20 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL3 | SNV | Missense_Mutation | | c.343N>C | p.Asp115His | p.D115H | O60936 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NOL3 | SNV | Missense_Mutation | novel | c.60N>C | p.Gln20His | p.Q20H | O60936 | protein_coding | | benign(0.187) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NOL3 | SNV | Missense_Mutation | novel | c.604G>A | p.Glu202Lys | p.E202K | O60936 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.516) | TCGA-XS-A8TJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NOL3 | SNV | Missense_Mutation | novel | c.299N>T | p.Gly100Val | p.G100V | O60936 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL3 | SNV | Missense_Mutation | rs528140604 | c.635N>T | p.Pro212Leu | p.P212L | O60936 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
NOL3 | insertion | Frame_Shift_Ins | novel | c.190_191insC | p.Gly64AlafsTer52 | p.G64Afs*52 | O60936 | protein_coding | | | TCGA-AP-A0LH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
NOL3 | SNV | Missense_Mutation | novel | c.796G>A | p.Glu266Lys | p.E266K | O60936 | protein_coding | deleterious_low_confidence(0) | benign(0.042) | TCGA-CV-7097-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NOL3 | SNV | Missense_Mutation | | c.514N>A | p.Pro172Thr | p.P172T | O60936 | protein_coding | tolerated_low_confidence(0.08) | benign(0.025) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
NOL3 | SNV | Missense_Mutation | rs547594151 | c.259G>A | p.Ala87Thr | p.A87T | O60936 | protein_coding | tolerated_low_confidence(0.25) | benign(0.196) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |