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Gene: INE1 |
Gene summary for INE1 |
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Gene information | Species | Human | Gene symbol | INE1 | Gene ID | 8552 |
Gene name | inactivation escape 1 | |
Gene Alias | NCRNA00010 | |
Cytomap | Xp11.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8552 | INE1 | HCC1 | Human | Liver | HCC | 2.10e-06 | 1.87e+00 | 0.5336 |
8552 | INE1 | HCC2 | Human | Liver | HCC | 2.78e-04 | 7.61e-01 | 0.5341 |
8552 | INE1 | HCC5 | Human | Liver | HCC | 2.57e-02 | 4.34e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00316383 | Oral cavity | LP | zymogen activation | 26/4623 | 60/18723 | 1.19e-03 | 9.62e-03 | 26 |
GO:000223718 | Oral cavity | LP | response to molecule of bacterial origin | 115/4623 | 363/18723 | 1.42e-03 | 1.13e-02 | 115 |
GO:00109551 | Oral cavity | LP | negative regulation of protein processing | 15/4623 | 29/18723 | 1.55e-03 | 1.20e-02 | 15 |
GO:19033181 | Oral cavity | LP | negative regulation of protein maturation | 15/4623 | 29/18723 | 1.55e-03 | 1.20e-02 | 15 |
GO:001095118 | Oral cavity | LP | negative regulation of endopeptidase activity | 83/4623 | 252/18723 | 1.86e-03 | 1.39e-02 | 83 |
GO:007122214 | Oral cavity | LP | cellular response to lipopolysaccharide | 69/4623 | 209/18723 | 3.99e-03 | 2.59e-02 | 69 |
GO:190204116 | Oral cavity | LP | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 21/4623 | 49/18723 | 4.00e-03 | 2.59e-02 | 21 |
GO:0010810110 | Oral cavity | LP | regulation of cell-substrate adhesion | 72/4623 | 221/18723 | 4.80e-03 | 3.03e-02 | 72 |
GO:000756914 | Oral cavity | LP | cell aging | 46/4623 | 132/18723 | 5.64e-03 | 3.40e-02 | 46 |
GO:003158918 | Oral cavity | LP | cell-substrate adhesion | 111/4623 | 363/18723 | 5.94e-03 | 3.53e-02 | 111 |
GO:004580717 | Oral cavity | LP | positive regulation of endocytosis | 36/4623 | 100/18723 | 7.54e-03 | 4.16e-02 | 36 |
GO:004206033 | Oral cavity | NEOLP | wound healing | 106/2005 | 422/18723 | 1.93e-17 | 1.91e-14 | 106 |
GO:200123334 | Oral cavity | NEOLP | regulation of apoptotic signaling pathway | 94/2005 | 356/18723 | 4.19e-17 | 3.11e-14 | 94 |
GO:003158932 | Oral cavity | NEOLP | cell-substrate adhesion | 93/2005 | 363/18723 | 4.93e-16 | 2.93e-13 | 93 |
GO:001081033 | Oral cavity | NEOLP | regulation of cell-substrate adhesion | 60/2005 | 221/18723 | 5.88e-12 | 1.03e-09 | 60 |
GO:000716023 | Oral cavity | NEOLP | cell-matrix adhesion | 62/2005 | 233/18723 | 6.73e-12 | 1.14e-09 | 62 |
GO:005254733 | Oral cavity | NEOLP | regulation of peptidase activity | 98/2005 | 461/18723 | 1.77e-11 | 2.56e-09 | 98 |
GO:200123433 | Oral cavity | NEOLP | negative regulation of apoptotic signaling pathway | 59/2005 | 224/18723 | 3.40e-11 | 4.59e-09 | 59 |
GO:000195223 | Oral cavity | NEOLP | regulation of cell-matrix adhesion | 41/2005 | 128/18723 | 5.14e-11 | 6.30e-09 | 41 |
GO:200123632 | Oral cavity | NEOLP | regulation of extrinsic apoptotic signaling pathway | 44/2005 | 151/18723 | 3.30e-10 | 2.97e-08 | 44 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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