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Gene: DAG1 |
Gene summary for DAG1 |
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Gene information | Species | Human | Gene symbol | DAG1 | Gene ID | 1605 |
Gene name | dystroglycan 1 | |
Gene Alias | 156DAG | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R2W4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1605 | DAG1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.22e-11 | 6.63e-01 | -0.0811 |
1605 | DAG1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.67e-02 | 2.93e-01 | -0.1088 |
1605 | DAG1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-08 | 3.92e-01 | -0.1954 |
1605 | DAG1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.91e-02 | 1.97e-01 | -0.1526 |
1605 | DAG1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.20e-12 | 6.31e-01 | -0.059 |
1605 | DAG1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.36e-05 | 3.07e-01 | 0.096 |
1605 | DAG1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.15e-03 | 3.57e-01 | 0.294 |
1605 | DAG1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.35e-04 | 9.04e-01 | 0.3487 |
1605 | DAG1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.89e-09 | 5.51e-01 | 0.3859 |
1605 | DAG1 | A015-C-203 | Human | Colorectum | FAP | 6.70e-04 | -1.37e-01 | -0.1294 |
1605 | DAG1 | A015-C-104 | Human | Colorectum | FAP | 4.77e-04 | -1.40e-01 | -0.1899 |
1605 | DAG1 | A002-C-016 | Human | Colorectum | FAP | 8.81e-03 | -1.05e-01 | 0.0521 |
1605 | DAG1 | A002-C-116 | Human | Colorectum | FAP | 8.22e-03 | -1.01e-01 | -0.0452 |
1605 | DAG1 | LZE2T | Human | Esophagus | ESCC | 2.55e-02 | 4.36e-01 | 0.082 |
1605 | DAG1 | LZE4T | Human | Esophagus | ESCC | 4.25e-04 | 1.73e-01 | 0.0811 |
1605 | DAG1 | LZE7T | Human | Esophagus | ESCC | 4.60e-03 | 4.42e-01 | 0.0667 |
1605 | DAG1 | LZE8T | Human | Esophagus | ESCC | 1.12e-02 | 5.43e-02 | 0.067 |
1605 | DAG1 | LZE24T | Human | Esophagus | ESCC | 2.33e-11 | 2.82e-01 | 0.0596 |
1605 | DAG1 | LZE21T | Human | Esophagus | ESCC | 1.68e-05 | 2.87e-01 | 0.0655 |
1605 | DAG1 | P2T-E | Human | Esophagus | ESCC | 3.63e-15 | 2.63e-01 | 0.1177 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190437521 | Liver | HCC | regulation of protein localization to cell periphery | 83/7958 | 125/18723 | 5.60e-08 | 1.19e-06 | 83 |
GO:005212612 | Liver | HCC | movement in host environment | 109/7958 | 175/18723 | 9.58e-08 | 1.89e-06 | 109 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:00518172 | Liver | HCC | modulation of process of other organism involved in symbiotic interaction | 56/7958 | 81/18723 | 1.11e-06 | 1.65e-05 | 56 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:000756822 | Liver | HCC | aging | 185/7958 | 339/18723 | 4.28e-06 | 5.50e-05 | 185 |
GO:000836022 | Liver | HCC | regulation of cell shape | 92/7958 | 154/18723 | 1.15e-05 | 1.31e-04 | 92 |
GO:003582111 | Liver | HCC | modulation of process of other organism | 67/7958 | 106/18723 | 1.34e-05 | 1.48e-04 | 67 |
GO:001081022 | Liver | HCC | regulation of cell-substrate adhesion | 123/7958 | 221/18723 | 5.15e-05 | 4.90e-04 | 123 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:004440912 | Liver | HCC | entry into host | 88/7958 | 151/18723 | 6.47e-05 | 5.91e-04 | 88 |
GO:009730522 | Liver | HCC | response to alcohol | 138/7958 | 253/18723 | 6.91e-05 | 6.26e-04 | 138 |
GO:004671812 | Liver | HCC | viral entry into host cell | 83/7958 | 144/18723 | 1.73e-04 | 1.36e-03 | 83 |
GO:003158922 | Liver | HCC | cell-substrate adhesion | 188/7958 | 363/18723 | 2.00e-04 | 1.55e-03 | 188 |
GO:000195221 | Liver | HCC | regulation of cell-matrix adhesion | 74/7958 | 128/18723 | 3.34e-04 | 2.34e-03 | 74 |
GO:001072011 | Liver | HCC | positive regulation of cell development | 155/7958 | 298/18723 | 5.39e-04 | 3.48e-03 | 155 |
GO:00310992 | Liver | HCC | regeneration | 107/7958 | 198/18723 | 6.67e-04 | 4.12e-03 | 107 |
GO:00434097 | Liver | HCC | negative regulation of MAPK cascade | 98/7958 | 180/18723 | 7.88e-04 | 4.74e-03 | 98 |
GO:001081122 | Liver | HCC | positive regulation of cell-substrate adhesion | 70/7958 | 123/18723 | 8.74e-04 | 5.18e-03 | 70 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05416 | Colorectum | MSI-H | Viral myocarditis | 14/797 | 60/8465 | 1.09e-03 | 1.20e-02 | 1.01e-02 | 14 |
hsa054161 | Colorectum | MSI-H | Viral myocarditis | 14/797 | 60/8465 | 1.09e-03 | 1.20e-02 | 1.01e-02 | 14 |
hsa05412 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa054121 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa0541630 | Esophagus | ESCC | Viral myocarditis | 41/4205 | 60/8465 | 2.59e-03 | 7.05e-03 | 3.61e-03 | 41 |
hsa05416114 | Esophagus | ESCC | Viral myocarditis | 41/4205 | 60/8465 | 2.59e-03 | 7.05e-03 | 3.61e-03 | 41 |
hsa0541614 | Liver | Cirrhotic | Viral myocarditis | 28/2530 | 60/8465 | 4.38e-03 | 1.68e-02 | 1.03e-02 | 28 |
hsa0541615 | Liver | Cirrhotic | Viral myocarditis | 28/2530 | 60/8465 | 4.38e-03 | 1.68e-02 | 1.03e-02 | 28 |
hsa0541629 | Oral cavity | OSCC | Viral myocarditis | 39/3704 | 60/8465 | 7.13e-04 | 2.09e-03 | 1.07e-03 | 39 |
hsa05416113 | Oral cavity | OSCC | Viral myocarditis | 39/3704 | 60/8465 | 7.13e-04 | 2.09e-03 | 1.07e-03 | 39 |
hsa05416210 | Oral cavity | LP | Viral myocarditis | 32/2418 | 60/8465 | 4.55e-05 | 2.91e-04 | 1.88e-04 | 32 |
hsa0541637 | Oral cavity | LP | Viral myocarditis | 32/2418 | 60/8465 | 4.55e-05 | 2.91e-04 | 1.88e-04 | 32 |
hsa0541628 | Prostate | Tumor | Viral myocarditis | 24/1791 | 60/8465 | 6.83e-04 | 3.33e-03 | 2.06e-03 | 24 |
hsa0541636 | Prostate | Tumor | Viral myocarditis | 24/1791 | 60/8465 | 6.83e-04 | 3.33e-03 | 2.06e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
LAMA2 | DAG1 | LAMA2_DAG1 | LAMININ | Breast | DCIS |
LAMA3 | DAG1 | LAMA3_DAG1 | LAMININ | Breast | DCIS |
LAMA4 | DAG1 | LAMA4_DAG1 | LAMININ | Breast | DCIS |
LAMB1 | DAG1 | LAMB1_DAG1 | LAMININ | Breast | DCIS |
LAMB2 | DAG1 | LAMB2_DAG1 | LAMININ | Breast | DCIS |
LAMC1 | DAG1 | LAMC1_DAG1 | LAMININ | Breast | DCIS |
HSPG2 | DAG1 | HSPG2_DAG1 | HSPG | Breast | DCIS |
LAMA2 | DAG1 | LAMA2_DAG1 | LAMININ | Cervix | Precancer |
LAMA3 | DAG1 | LAMA3_DAG1 | LAMININ | Cervix | Precancer |
LAMA4 | DAG1 | LAMA4_DAG1 | LAMININ | Cervix | Precancer |
LAMA5 | DAG1 | LAMA5_DAG1 | LAMININ | Cervix | Precancer |
LAMB1 | DAG1 | LAMB1_DAG1 | LAMININ | Cervix | Precancer |
LAMB2 | DAG1 | LAMB2_DAG1 | LAMININ | Cervix | Precancer |
LAMB3 | DAG1 | LAMB3_DAG1 | LAMININ | Cervix | Precancer |
LAMC1 | DAG1 | LAMC1_DAG1 | LAMININ | Cervix | Precancer |
LAMC3 | DAG1 | LAMC3_DAG1 | LAMININ | Cervix | Precancer |
HSPG2 | DAG1 | HSPG2_DAG1 | HSPG | Cervix | Precancer |
AGRN | DAG1 | AGRN_DAG1 | AGRN | Cervix | Precancer |
LAMA2 | DAG1 | LAMA2_DAG1 | LAMININ | CRC | AD |
LAMA4 | DAG1 | LAMA4_DAG1 | LAMININ | CRC | AD |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DAG1 | insertion | Frame_Shift_Ins | novel | c.273_274insAACCACTG | p.Asp92AsnfsTer45 | p.D92Nfs*45 | Q14118 | protein_coding | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
DAG1 | insertion | Frame_Shift_Ins | novel | c.275_276insATTGCTCAAGTCTAAACCTGCTTTTCTT | p.Asp92GlufsTer41 | p.D92Efs*41 | Q14118 | protein_coding | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
DAG1 | deletion | Frame_Shift_Del | novel | c.1477delN | p.Asn494ThrfsTer13 | p.N494Tfs*13 | Q14118 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DAG1 | deletion | Frame_Shift_Del | novel | c.2389delN | p.Pro797LeufsTer46 | p.P797Lfs*46 | Q14118 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DAG1 | deletion | Frame_Shift_Del | novel | c.836delN | p.Pro280LeufsTer103 | p.P280Lfs*103 | Q14118 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
DAG1 | SNV | Missense_Mutation | novel | c.592G>A | p.Asp198Asn | p.D198N | Q14118 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DAG1 | SNV | Missense_Mutation | rs562046526 | c.643C>T | p.Arg215Trp | p.R215W | Q14118 | protein_coding | deleterious(0) | benign(0.402) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DAG1 | SNV | Missense_Mutation | rs752984606 | c.1118N>A | p.Arg373Gln | p.R373Q | Q14118 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
DAG1 | SNV | Missense_Mutation | c.266C>T | p.Ser89Phe | p.S89F | Q14118 | protein_coding | tolerated(0.22) | possibly_damaging(0.731) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DAG1 | SNV | Missense_Mutation | c.2666N>A | p.Pro889His | p.P889H | Q14118 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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