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Gene: CHMP2B |
Gene summary for CHMP2B |
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Gene information | Species | Human | Gene symbol | CHMP2B | Gene ID | 25978 |
Gene name | charged multivesicular body protein 2B | |
Gene Alias | ALS17 | |
Cytomap | 3p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | B2RE76 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25978 | CHMP2B | LZE4T | Human | Esophagus | ESCC | 4.43e-11 | 2.26e-01 | 0.0811 |
25978 | CHMP2B | LZE5T | Human | Esophagus | ESCC | 4.45e-04 | 3.61e-01 | 0.0514 |
25978 | CHMP2B | LZE7T | Human | Esophagus | ESCC | 3.01e-06 | 6.51e-02 | 0.0667 |
25978 | CHMP2B | LZE8T | Human | Esophagus | ESCC | 5.57e-06 | 5.19e-01 | 0.067 |
25978 | CHMP2B | LZE20T | Human | Esophagus | ESCC | 3.32e-03 | 2.22e-01 | 0.0662 |
25978 | CHMP2B | LZE24T | Human | Esophagus | ESCC | 7.25e-16 | 7.64e-01 | 0.0596 |
25978 | CHMP2B | LZE6T | Human | Esophagus | ESCC | 1.25e-06 | 9.44e-02 | 0.0845 |
25978 | CHMP2B | P2T-E | Human | Esophagus | ESCC | 1.13e-22 | 2.80e-01 | 0.1177 |
25978 | CHMP2B | P4T-E | Human | Esophagus | ESCC | 5.67e-24 | 6.00e-01 | 0.1323 |
25978 | CHMP2B | P5T-E | Human | Esophagus | ESCC | 1.33e-09 | 1.78e-01 | 0.1327 |
25978 | CHMP2B | P8T-E | Human | Esophagus | ESCC | 4.98e-16 | 3.59e-01 | 0.0889 |
25978 | CHMP2B | P9T-E | Human | Esophagus | ESCC | 1.19e-15 | 1.86e-01 | 0.1131 |
25978 | CHMP2B | P10T-E | Human | Esophagus | ESCC | 1.70e-13 | 2.15e-01 | 0.116 |
25978 | CHMP2B | P11T-E | Human | Esophagus | ESCC | 2.97e-12 | 9.60e-01 | 0.1426 |
25978 | CHMP2B | P12T-E | Human | Esophagus | ESCC | 1.12e-18 | 3.79e-01 | 0.1122 |
25978 | CHMP2B | P15T-E | Human | Esophagus | ESCC | 3.70e-17 | 3.82e-01 | 0.1149 |
25978 | CHMP2B | P16T-E | Human | Esophagus | ESCC | 1.43e-17 | 2.38e-01 | 0.1153 |
25978 | CHMP2B | P17T-E | Human | Esophagus | ESCC | 5.56e-03 | 2.25e-01 | 0.1278 |
25978 | CHMP2B | P19T-E | Human | Esophagus | ESCC | 4.43e-06 | 8.70e-01 | 0.1662 |
25978 | CHMP2B | P20T-E | Human | Esophagus | ESCC | 3.37e-21 | 5.47e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004440318 | Prostate | BPH | biological process involved in symbiotic interaction | 90/3107 | 290/18723 | 6.98e-10 | 3.25e-08 | 90 |
GO:005170118 | Prostate | BPH | biological process involved in interaction with host | 69/3107 | 203/18723 | 9.94e-10 | 4.56e-08 | 69 |
GO:002241117 | Prostate | BPH | cellular component disassembly | 121/3107 | 443/18723 | 6.34e-09 | 2.25e-07 | 121 |
GO:00516569 | Prostate | BPH | establishment of organelle localization | 107/3107 | 390/18723 | 3.67e-08 | 1.03e-06 | 107 |
GO:00162369 | Prostate | BPH | macroautophagy | 85/3107 | 291/18723 | 4.68e-08 | 1.29e-06 | 85 |
GO:005079218 | Prostate | BPH | regulation of viral process | 53/3107 | 164/18723 | 5.22e-07 | 1.04e-05 | 53 |
GO:00009109 | Prostate | BPH | cytokinesis | 55/3107 | 173/18723 | 5.81e-07 | 1.15e-05 | 55 |
GO:00705076 | Prostate | BPH | regulation of microtubule cytoskeleton organization | 48/3107 | 148/18723 | 1.57e-06 | 2.67e-05 | 48 |
GO:00160507 | Prostate | BPH | vesicle organization | 82/3107 | 300/18723 | 1.64e-06 | 2.78e-05 | 82 |
GO:004852415 | Prostate | BPH | positive regulation of viral process | 27/3107 | 65/18723 | 1.65e-06 | 2.78e-05 | 27 |
GO:00329849 | Prostate | BPH | protein-containing complex disassembly | 65/3107 | 224/18723 | 2.19e-06 | 3.60e-05 | 65 |
GO:00508087 | Prostate | BPH | synapse organization | 103/3107 | 426/18723 | 3.19e-05 | 3.61e-04 | 103 |
GO:00991736 | Prostate | BPH | postsynapse organization | 49/3107 | 168/18723 | 3.20e-05 | 3.61e-04 | 49 |
GO:00161978 | Prostate | BPH | endosomal transport | 62/3107 | 230/18723 | 4.54e-05 | 4.77e-04 | 62 |
GO:00070349 | Prostate | BPH | vacuolar transport | 46/3107 | 157/18723 | 4.86e-05 | 5.07e-04 | 46 |
GO:00328862 | Prostate | BPH | regulation of microtubule-based process | 64/3107 | 240/18723 | 4.93e-05 | 5.11e-04 | 64 |
GO:00901694 | Prostate | BPH | regulation of spindle assembly | 13/3107 | 25/18723 | 5.04e-05 | 5.21e-04 | 13 |
GO:19028505 | Prostate | BPH | microtubule cytoskeleton organization involved in mitosis | 43/3107 | 147/18723 | 8.78e-05 | 8.27e-04 | 43 |
GO:190390018 | Prostate | BPH | regulation of viral life cycle | 43/3107 | 148/18723 | 1.04e-04 | 9.58e-04 | 43 |
GO:00070525 | Prostate | BPH | mitotic spindle organization | 36/3107 | 120/18723 | 1.83e-04 | 1.54e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP2B | SNV | Missense_Mutation | c.369N>C | p.Gln123His | p.Q123H | Q9UQN3 | protein_coding | deleterious(0.03) | possibly_damaging(0.77) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | c.296N>T | p.Ala99Val | p.A99V | Q9UQN3 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | c.194T>G | p.Leu65Arg | p.L65R | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | novel | c.499N>A | p.Leu167Ile | p.L167I | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.554N>T | p.Ala185Val | p.A185V | Q9UQN3 | protein_coding | tolerated(0.28) | benign(0.028) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.327N>A | p.Met109Ile | p.M109I | Q9UQN3 | protein_coding | deleterious(0.01) | possibly_damaging(0.785) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.25A>T | p.Thr9Ser | p.T9S | Q9UQN3 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.238N>G | p.Ser80Ala | p.S80A | Q9UQN3 | protein_coding | tolerated(0.34) | benign(0.23) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.375N>A | p.Met125Ile | p.M125I | Q9UQN3 | protein_coding | deleterious(0.04) | benign(0.162) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.499C>A | p.Leu167Ile | p.L167I | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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