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Gene: AURKB |
Gene summary for AURKB |
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Gene information | Species | Human | Gene symbol | AURKB | Gene ID | 9212 |
Gene name | aurora kinase B | |
Gene Alias | AIK2 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000022 | UniProtAcc | Q96GD4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9212 | AURKB | P2T-E | Human | Esophagus | ESCC | 9.44e-07 | 4.81e-01 | 0.1177 |
9212 | AURKB | P4T-E | Human | Esophagus | ESCC | 1.49e-09 | 3.93e-01 | 0.1323 |
9212 | AURKB | P5T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.77e-01 | 0.1327 |
9212 | AURKB | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.55e-01 | 0.0889 |
9212 | AURKB | P9T-E | Human | Esophagus | ESCC | 6.74e-06 | 2.10e-01 | 0.1131 |
9212 | AURKB | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.30e-01 | 0.116 |
9212 | AURKB | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.55e-01 | 0.1153 |
9212 | AURKB | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 8.08e-01 | 0.1278 |
9212 | AURKB | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 9.56e-01 | 0.1662 |
9212 | AURKB | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 2.45e-01 | 0.1124 |
9212 | AURKB | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 3.60e-01 | 0.1617 |
9212 | AURKB | P24T-E | Human | Esophagus | ESCC | 5.30e-21 | 6.19e-01 | 0.1287 |
9212 | AURKB | P28T-E | Human | Esophagus | ESCC | 1.33e-02 | 1.58e-01 | 0.1149 |
9212 | AURKB | P31T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.49e-01 | 0.1251 |
9212 | AURKB | P32T-E | Human | Esophagus | ESCC | 2.56e-16 | 5.84e-01 | 0.1666 |
9212 | AURKB | P36T-E | Human | Esophagus | ESCC | 1.12e-05 | 3.33e-01 | 0.1187 |
9212 | AURKB | P37T-E | Human | Esophagus | ESCC | 1.03e-11 | 4.07e-01 | 0.1371 |
9212 | AURKB | P38T-E | Human | Esophagus | ESCC | 1.45e-09 | 5.86e-01 | 0.127 |
9212 | AURKB | P42T-E | Human | Esophagus | ESCC | 2.62e-05 | 2.92e-01 | 0.1175 |
9212 | AURKB | P44T-E | Human | Esophagus | ESCC | 6.93e-04 | 2.60e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477219 | Thyroid | ATC | mitotic cell cycle phase transition | 223/6293 | 424/18723 | 3.46e-16 | 2.88e-14 | 223 |
GO:000007013 | Thyroid | ATC | mitotic sister chromatid segregation | 108/6293 | 168/18723 | 3.53e-16 | 2.90e-14 | 108 |
GO:000734622 | Thyroid | ATC | regulation of mitotic cell cycle | 236/6293 | 457/18723 | 7.58e-16 | 5.92e-14 | 236 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:000081913 | Thyroid | ATC | sister chromatid segregation | 122/6293 | 202/18723 | 4.71e-15 | 3.17e-13 | 122 |
GO:190285017 | Thyroid | ATC | microtubule cytoskeleton organization involved in mitosis | 95/6293 | 147/18723 | 1.29e-14 | 7.62e-13 | 95 |
GO:007233135 | Thyroid | ATC | signal transduction by p53 class mediator | 102/6293 | 163/18723 | 3.16e-14 | 1.75e-12 | 102 |
GO:000705913 | Thyroid | ATC | chromosome segregation | 183/6293 | 346/18723 | 8.03e-14 | 4.23e-12 | 183 |
GO:000705222 | Thyroid | ATC | mitotic spindle organization | 80/6293 | 120/18723 | 1.27e-13 | 6.46e-12 | 80 |
GO:190179635 | Thyroid | ATC | regulation of signal transduction by p53 class mediator | 66/6293 | 93/18723 | 1.86e-13 | 9.20e-12 | 66 |
GO:000705122 | Thyroid | ATC | spindle organization | 109/6293 | 184/18723 | 7.99e-13 | 3.46e-11 | 109 |
GO:001063926 | Thyroid | ATC | negative regulation of organelle organization | 179/6293 | 348/18723 | 3.74e-12 | 1.50e-10 | 179 |
GO:005105219 | Thyroid | ATC | regulation of DNA metabolic process | 183/6293 | 359/18723 | 5.97e-12 | 2.30e-10 | 183 |
GO:190199015 | Thyroid | ATC | regulation of mitotic cell cycle phase transition | 156/6293 | 299/18723 | 2.19e-11 | 7.80e-10 | 156 |
GO:007121427 | Thyroid | ATC | cellular response to abiotic stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:010400427 | Thyroid | ATC | cellular response to environmental stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:004339327 | Thyroid | ATC | regulation of protein binding | 110/6293 | 196/18723 | 6.99e-11 | 2.22e-09 | 110 |
GO:005198311 | Thyroid | ATC | regulation of chromosome segregation | 60/6293 | 91/18723 | 2.83e-10 | 8.10e-09 | 60 |
GO:009881312 | Thyroid | ATC | nuclear chromosome segregation | 145/6293 | 281/18723 | 3.06e-10 | 8.61e-09 | 145 |
GO:003007111 | Thyroid | ATC | regulation of mitotic metaphase/anaphase transition | 44/6293 | 60/18723 | 3.54e-10 | 9.86e-09 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AURKB | SNV | Missense_Mutation | c.386N>C | p.Ile129Thr | p.I129T | Q96GD4 | protein_coding | deleterious(0) | possibly_damaging(0.566) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD | |
AURKB | SNV | Missense_Mutation | rs749454960 | c.745N>T | p.Arg249Cys | p.R249C | Q96GD4 | protein_coding | deleterious(0.02) | benign(0.012) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AURKB | SNV | Missense_Mutation | rs772022668 | c.481N>A | p.Gly161Arg | p.G161R | Q96GD4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AURKB | SNV | Missense_Mutation | c.371G>A | p.Arg124His | p.R124H | Q96GD4 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
AURKB | SNV | Missense_Mutation | c.595C>T | p.His199Tyr | p.H199Y | Q96GD4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AURKB | SNV | Missense_Mutation | rs768656332 | c.897G>T | p.Met299Ile | p.M299I | Q96GD4 | protein_coding | tolerated(0.17) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AURKB | SNV | Missense_Mutation | rs201709756 | c.1033N>A | p.Ala345Thr | p.A345T | Q96GD4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.015) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AURKB | SNV | Missense_Mutation | rs780771169 | c.89N>A | p.Arg30Gln | p.R30Q | Q96GD4 | protein_coding | tolerated(0.68) | benign(0.007) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AURKB | SNV | Missense_Mutation | rs55871613 | c.539N>T | p.Thr180Met | p.T180M | Q96GD4 | protein_coding | deleterious(0.02) | benign(0.228) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AURKB | SNV | Missense_Mutation | novel | c.50N>T | p.Ala17Val | p.A17V | Q96GD4 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | ZM-447439 | CHEMBL202721 | ||
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 178102344 | TOZASERTIB | |
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | LINIFANIB | LINIFANIB | ||
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | PAZOPANIB | PAZOPANIB | ||
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | CHEMBL495727 | AT-9283 | |
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 249565620 | DANUSERTIB | |
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | CYC116 | |||
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | CHEMBL3545327 | TTP-607 | |
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | BAY-613606 | CHEMBL541400 | ||
9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 249565688 | CHEMBL1765740 |
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