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Gene: ATP5PB |
Gene summary for ATP5PB |
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Gene information | Species | Human | Gene symbol | ATP5PB | Gene ID | 515 |
Gene name | ATP synthase peripheral stalk-membrane subunit b | |
Gene Alias | ATP5F1 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P24539 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
515 | ATP5PB | GSM4909281 | Human | Breast | IDC | 1.19e-05 | 2.50e-01 | 0.21 |
515 | ATP5PB | GSM4909282 | Human | Breast | IDC | 1.71e-28 | 6.60e-01 | -0.0288 |
515 | ATP5PB | GSM4909285 | Human | Breast | IDC | 5.07e-45 | 7.56e-01 | 0.21 |
515 | ATP5PB | GSM4909286 | Human | Breast | IDC | 1.33e-06 | 1.13e-01 | 0.1081 |
515 | ATP5PB | GSM4909288 | Human | Breast | IDC | 1.62e-04 | 4.94e-01 | 0.0988 |
515 | ATP5PB | GSM4909290 | Human | Breast | IDC | 3.52e-04 | 2.67e-01 | 0.2096 |
515 | ATP5PB | GSM4909291 | Human | Breast | IDC | 2.44e-05 | 3.89e-01 | 0.1753 |
515 | ATP5PB | GSM4909293 | Human | Breast | IDC | 3.52e-03 | 3.11e-02 | 0.1581 |
515 | ATP5PB | GSM4909294 | Human | Breast | IDC | 2.01e-02 | 2.97e-01 | 0.2022 |
515 | ATP5PB | GSM4909296 | Human | Breast | IDC | 7.49e-07 | 2.52e-01 | 0.1524 |
515 | ATP5PB | GSM4909298 | Human | Breast | IDC | 1.34e-09 | 2.76e-01 | 0.1551 |
515 | ATP5PB | GSM4909304 | Human | Breast | IDC | 1.42e-04 | 2.91e-01 | 0.1636 |
515 | ATP5PB | GSM4909305 | Human | Breast | IDC | 1.13e-11 | 4.22e-01 | 0.0436 |
515 | ATP5PB | GSM4909306 | Human | Breast | IDC | 4.98e-06 | 2.99e-01 | 0.1564 |
515 | ATP5PB | GSM4909308 | Human | Breast | IDC | 2.21e-07 | 2.53e-01 | 0.158 |
515 | ATP5PB | GSM4909311 | Human | Breast | IDC | 3.71e-14 | 7.62e-02 | 0.1534 |
515 | ATP5PB | GSM4909312 | Human | Breast | IDC | 1.64e-16 | 4.84e-01 | 0.1552 |
515 | ATP5PB | GSM4909315 | Human | Breast | IDC | 3.99e-03 | 3.10e-01 | 0.21 |
515 | ATP5PB | GSM4909317 | Human | Breast | IDC | 5.33e-09 | 3.09e-01 | 0.1355 |
515 | ATP5PB | GSM4909319 | Human | Breast | IDC | 5.59e-19 | -5.60e-02 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000919915 | Endometrium | EEC | ribonucleoside triphosphate metabolic process | 31/2168 | 89/18723 | 7.48e-09 | 4.83e-07 | 31 |
GO:004277615 | Endometrium | EEC | mitochondrial ATP synthesis coupled proton transport | 13/2168 | 19/18723 | 8.98e-09 | 5.73e-07 | 13 |
GO:000914216 | Endometrium | EEC | nucleoside triphosphate biosynthetic process | 30/2168 | 85/18723 | 9.15e-09 | 5.78e-07 | 30 |
GO:000914116 | Endometrium | EEC | nucleoside triphosphate metabolic process | 35/2168 | 112/18723 | 2.08e-08 | 1.25e-06 | 35 |
GO:190260014 | Endometrium | EEC | proton transmembrane transport | 43/2168 | 157/18723 | 4.32e-08 | 2.38e-06 | 43 |
GO:199054216 | Endometrium | EEC | mitochondrial transmembrane transport | 31/2168 | 102/18723 | 2.65e-07 | 1.11e-05 | 31 |
GO:002176216 | Endometrium | EEC | substantia nigra development | 16/2168 | 44/18723 | 1.71e-05 | 3.26e-04 | 16 |
GO:000915017 | Endometrium | EEC | purine ribonucleotide metabolic process | 69/2168 | 368/18723 | 3.38e-05 | 5.77e-04 | 69 |
GO:000616317 | Endometrium | EEC | purine nucleotide metabolic process | 71/2168 | 396/18723 | 1.14e-04 | 1.54e-03 | 71 |
GO:000925916 | Endometrium | EEC | ribonucleotide metabolic process | 69/2168 | 385/18723 | 1.43e-04 | 1.84e-03 | 69 |
GO:003090113 | Endometrium | EEC | midbrain development | 23/2168 | 90/18723 | 1.80e-04 | 2.21e-03 | 23 |
GO:007252117 | Endometrium | EEC | purine-containing compound metabolic process | 73/2168 | 416/18723 | 1.82e-04 | 2.24e-03 | 73 |
GO:001969316 | Endometrium | EEC | ribose phosphate metabolic process | 70/2168 | 396/18723 | 1.96e-04 | 2.38e-03 | 70 |
GO:000915216 | Endometrium | EEC | purine ribonucleotide biosynthetic process | 36/2168 | 169/18723 | 2.03e-04 | 2.45e-03 | 36 |
GO:004885714 | Endometrium | EEC | neural nucleus development | 18/2168 | 64/18723 | 2.47e-04 | 2.88e-03 | 18 |
GO:000911716 | Endometrium | EEC | nucleotide metabolic process | 80/2168 | 489/18723 | 8.65e-04 | 7.95e-03 | 80 |
GO:000926015 | Endometrium | EEC | ribonucleotide biosynthetic process | 36/2168 | 182/18723 | 8.83e-04 | 8.03e-03 | 36 |
GO:004639015 | Endometrium | EEC | ribose phosphate biosynthetic process | 37/2168 | 190/18723 | 1.02e-03 | 8.98e-03 | 37 |
GO:000675315 | Endometrium | EEC | nucleoside phosphate metabolic process | 80/2168 | 497/18723 | 1.39e-03 | 1.14e-02 | 80 |
GO:000616414 | Endometrium | EEC | purine nucleotide biosynthetic process | 36/2168 | 191/18723 | 2.14e-03 | 1.61e-02 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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