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Gene: ANXA1 |
Gene summary for ANXA1 |
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Gene information | Species | Human | Gene symbol | ANXA1 | Gene ID | 301 |
Gene name | annexin A1 | |
Gene Alias | ANX1 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P04083 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
301 | ANXA1 | GSM4909281 | Human | Breast | IDC | 9.72e-06 | -3.81e-01 | 0.21 |
301 | ANXA1 | GSM4909282 | Human | Breast | IDC | 9.16e-07 | -1.64e-01 | -0.0288 |
301 | ANXA1 | GSM4909285 | Human | Breast | IDC | 6.68e-16 | -5.41e-01 | 0.21 |
301 | ANXA1 | GSM4909286 | Human | Breast | IDC | 3.03e-23 | -8.52e-01 | 0.1081 |
301 | ANXA1 | GSM4909287 | Human | Breast | IDC | 8.76e-03 | -3.28e-01 | 0.2057 |
301 | ANXA1 | GSM4909290 | Human | Breast | IDC | 5.24e-23 | -9.23e-01 | 0.2096 |
301 | ANXA1 | GSM4909291 | Human | Breast | IDC | 1.57e-23 | -1.00e+00 | 0.1753 |
301 | ANXA1 | GSM4909292 | Human | Breast | IDC | 2.62e-07 | -1.08e+00 | 0.1236 |
301 | ANXA1 | GSM4909293 | Human | Breast | IDC | 1.21e-21 | -7.81e-01 | 0.1581 |
301 | ANXA1 | GSM4909294 | Human | Breast | IDC | 1.44e-29 | -8.53e-01 | 0.2022 |
301 | ANXA1 | GSM4909296 | Human | Breast | IDC | 1.71e-36 | -9.89e-01 | 0.1524 |
301 | ANXA1 | GSM4909297 | Human | Breast | IDC | 6.02e-27 | -7.85e-01 | 0.1517 |
301 | ANXA1 | GSM4909298 | Human | Breast | IDC | 1.37e-29 | -8.73e-01 | 0.1551 |
301 | ANXA1 | GSM4909299 | Human | Breast | IDC | 1.47e-07 | 4.25e-01 | 0.035 |
301 | ANXA1 | GSM4909301 | Human | Breast | IDC | 2.31e-49 | -1.06e+00 | 0.1577 |
301 | ANXA1 | GSM4909302 | Human | Breast | IDC | 1.39e-28 | -9.03e-01 | 0.1545 |
301 | ANXA1 | GSM4909303 | Human | Breast | IDC | 5.04e-07 | -8.20e-01 | 0.0438 |
301 | ANXA1 | GSM4909304 | Human | Breast | IDC | 4.09e-44 | -1.05e+00 | 0.1636 |
301 | ANXA1 | GSM4909306 | Human | Breast | IDC | 5.39e-14 | -6.64e-01 | 0.1564 |
301 | ANXA1 | GSM4909307 | Human | Breast | IDC | 1.98e-15 | -6.60e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00329444 | Cervix | CC | regulation of mononuclear cell proliferation | 51/2311 | 227/18723 | 1.36e-05 | 2.73e-04 | 51 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:00310996 | Cervix | CC | regeneration | 46/2311 | 198/18723 | 1.43e-05 | 2.84e-04 | 46 |
GO:00508708 | Cervix | CC | positive regulation of T cell activation | 49/2311 | 216/18723 | 1.51e-05 | 2.97e-04 | 49 |
GO:00448434 | Cervix | CC | cell cycle G1/S phase transition | 53/2311 | 241/18723 | 1.76e-05 | 3.32e-04 | 53 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00459316 | Cervix | CC | positive regulation of mitotic cell cycle | 32/2311 | 121/18723 | 1.88e-05 | 3.47e-04 | 32 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:19037074 | Cervix | CC | negative regulation of hemopoiesis | 29/2311 | 106/18723 | 2.29e-05 | 4.01e-04 | 29 |
GO:00706617 | Cervix | CC | leukocyte proliferation | 65/2311 | 318/18723 | 2.56e-05 | 4.32e-04 | 65 |
GO:00610418 | Cervix | CC | regulation of wound healing | 34/2311 | 134/18723 | 2.70e-05 | 4.52e-04 | 34 |
GO:0002695 | Cervix | CC | negative regulation of leukocyte activation | 43/2311 | 187/18723 | 3.47e-05 | 5.60e-04 | 43 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00507273 | Cervix | CC | regulation of inflammatory response | 75/2311 | 386/18723 | 3.95e-05 | 6.18e-04 | 75 |
GO:19019922 | Cervix | CC | positive regulation of mitotic cell cycle phase transition | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
GO:00319609 | Cervix | CC | response to corticosteroid | 39/2311 | 167/18723 | 5.48e-05 | 8.06e-04 | 39 |
GO:00466516 | Cervix | CC | lymphocyte proliferation | 59/2311 | 288/18723 | 5.53e-05 | 8.10e-04 | 59 |
GO:0050868 | Cervix | CC | negative regulation of T cell activation | 31/2311 | 122/18723 | 5.81e-05 | 8.46e-04 | 31 |
GO:00329435 | Cervix | CC | mononuclear cell proliferation | 59/2311 | 291/18723 | 7.51e-05 | 1.03e-03 | 59 |
GO:00323556 | Cervix | CC | response to estradiol | 34/2311 | 141/18723 | 8.19e-05 | 1.11e-03 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Breast | DCIS |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Breast | IDC |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | ADJ |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | CC |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | CC |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | Healthy |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | Healthy |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | Precancer |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | Precancer |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | CRC | AD |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | CRC | MSI-H |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | AEH |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | EEC |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | GC | ADJ |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | HNSCC | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | HNSCC | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | HNSCC | Healthy |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Liver | HCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ANXA1 | PANIN | Pancreas | Healthy | VIM,LMNA,CAV1, etc. | 2.06e-01 | ![]() |
ANXA1 | LYMEND | Thyroid | ADJ | TPSB2,S100A10,ANXA2, etc. | 4.63e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANXA1 | SNV | Missense_Mutation | novel | c.428C>T | p.Ser143Leu | p.S143L | P04083 | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ANXA1 | SNV | Missense_Mutation | novel | c.37N>C | p.Phe13Leu | p.F13L | P04083 | protein_coding | tolerated(0.4) | benign(0.162) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ANXA1 | SNV | Missense_Mutation | c.80C>T | p.Ser27Leu | p.S27L | P04083 | protein_coding | tolerated(0.15) | benign(0) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ANXA1 | SNV | Missense_Mutation | novel | c.598G>A | p.Asp200Asn | p.D200N | P04083 | protein_coding | deleterious(0.02) | possibly_damaging(0.71) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ANXA1 | SNV | Missense_Mutation | novel | c.168N>A | p.Met56Ile | p.M56I | P04083 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
ANXA1 | SNV | Missense_Mutation | c.604G>A | p.Asp202Asn | p.D202N | P04083 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-A71X-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANXA1 | SNV | Missense_Mutation | c.831C>A | p.Phe277Leu | p.F277L | P04083 | protein_coding | deleterious(0.01) | possibly_damaging(0.5) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ANXA1 | SNV | Missense_Mutation | novel | c.881A>G | p.Lys294Arg | p.K294R | P04083 | protein_coding | tolerated(0.41) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ANXA1 | SNV | Missense_Mutation | rs142849845 | c.97N>A | p.Gly33Arg | p.G33R | P04083 | protein_coding | tolerated(0.27) | benign(0.037) | TCGA-CK-4948-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANXA1 | SNV | Missense_Mutation | c.901N>A | p.Val301Ile | p.V301I | P04083 | protein_coding | deleterious(0.02) | probably_damaging(0.945) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | RIMEXOLONE | RIMEXOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | CLOCORTOLONE | CLOCORTOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | PREDNISOLONE | PREDNISOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | BECLOMETHASONE | BECLOMETHASONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | MOMETASONE | MOMETASONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | METHYLPREDNISOLONE | METHYLPREDNISOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | AMCINONIDE | AMCINONIDE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | PPD | 11468004 | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | CLOBETASOL | CLOBETASOL | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | HYDROCORTISONE | HYDROCORTISONE | 1712816 |
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