GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000691326 | Thyroid | ATC | nucleocytoplasmic transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:005116926 | Thyroid | ATC | nuclear transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:000640326 | Thyroid | ATC | RNA localization | 132/6293 | 201/18723 | 1.13e-20 | 1.93e-18 | 132 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:000007013 | Thyroid | ATC | mitotic sister chromatid segregation | 108/6293 | 168/18723 | 3.53e-16 | 2.90e-14 | 108 |
GO:005116833 | Thyroid | ATC | nuclear export | 100/6293 | 154/18723 | 1.63e-15 | 1.20e-13 | 100 |
GO:000081913 | Thyroid | ATC | sister chromatid segregation | 122/6293 | 202/18723 | 4.71e-15 | 3.17e-13 | 122 |
GO:0046822112 | Thyroid | ATC | regulation of nucleocytoplasmic transport | 75/6293 | 106/18723 | 5.49e-15 | 3.62e-13 | 75 |
GO:000705913 | Thyroid | ATC | chromosome segregation | 183/6293 | 346/18723 | 8.03e-14 | 4.23e-12 | 183 |
GO:005123623 | Thyroid | ATC | establishment of RNA localization | 102/6293 | 166/18723 | 1.71e-13 | 8.60e-12 | 102 |
GO:005065722 | Thyroid | ATC | nucleic acid transport | 100/6293 | 163/18723 | 3.39e-13 | 1.56e-11 | 100 |
GO:005065822 | Thyroid | ATC | RNA transport | 100/6293 | 163/18723 | 3.39e-13 | 1.56e-11 | 100 |
GO:001593122 | Thyroid | ATC | nucleobase-containing compound transport | 122/6293 | 222/18723 | 4.30e-11 | 1.41e-09 | 122 |
GO:005102822 | Thyroid | ATC | mRNA transport | 80/6293 | 130/18723 | 6.13e-11 | 1.99e-09 | 80 |
GO:009881312 | Thyroid | ATC | nuclear chromosome segregation | 145/6293 | 281/18723 | 3.06e-10 | 8.61e-09 | 145 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:003105616 | Thyroid | ATC | regulation of histone modification | 85/6293 | 152/18723 | 1.23e-08 | 2.55e-07 | 85 |
GO:007116614 | Thyroid | ATC | ribonucleoprotein complex localization | 47/6293 | 77/18723 | 7.43e-07 | 9.89e-06 | 47 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKAP8 | SNV | Missense_Mutation | rs764482753 | c.1192N>T | p.Arg398Cys | p.R398C | O43823 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AKAP8 | SNV | Missense_Mutation | novel | c.1489C>T | p.Arg497Trp | p.R497W | O43823 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
AKAP8 | SNV | Missense_Mutation | rs767177827 | c.1268C>G | p.Thr423Ser | p.T423S | O43823 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AKAP8 | SNV | Missense_Mutation | | c.1600A>C | p.Lys534Gln | p.K534Q | O43823 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-E2-A1L7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
AKAP8 | SNV | Missense_Mutation | novel | c.1997N>C | p.Arg666Thr | p.R666T | O43823 | protein_coding | tolerated_low_confidence(0.6) | benign(0.005) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
AKAP8 | SNV | Missense_Mutation | | c.1581N>C | p.Leu527Phe | p.L527F | O43823 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
AKAP8 | SNV | Missense_Mutation | | c.374C>T | p.Ser125Phe | p.S125F | O43823 | protein_coding | deleterious(0.05) | benign(0.072) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
AKAP8 | SNV | Missense_Mutation | novel | c.1015T>G | p.Ser339Ala | p.S339A | O43823 | protein_coding | tolerated(0.09) | possibly_damaging(0.565) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AKAP8 | SNV | Missense_Mutation | | c.712N>T | p.Pro238Ser | p.P238S | O43823 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AKAP8 | SNV | Missense_Mutation | | c.2006N>T | p.Pro669Leu | p.P669L | O43823 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |