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Gene: TH |
Gene summary for TH |
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Gene information | Species | Human | Gene symbol | TH | Gene ID | 7054 |
Gene name | tyrosine hydroxylase | |
Gene Alias | DYT14 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P07101 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7054 | TH | C04 | Human | Oral cavity | OSCC | 2.26e-15 | 7.94e-01 | 0.2633 |
7054 | TH | C21 | Human | Oral cavity | OSCC | 3.65e-07 | 1.94e-01 | 0.2678 |
7054 | TH | C30 | Human | Oral cavity | OSCC | 2.87e-17 | 6.63e-01 | 0.3055 |
7054 | TH | C51 | Human | Oral cavity | OSCC | 4.98e-04 | 2.56e-01 | 0.2674 |
7054 | TH | SYSMH5 | Human | Oral cavity | OSCC | 3.73e-03 | 1.34e-01 | 0.0647 |
7054 | TH | P4_cSCC | Human | Skin | cSCC | 3.76e-02 | 9.18e-02 | -0.00290000000000005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00550769 | Prostate | BPH | transition metal ion homeostasis | 43/3107 | 138/18723 | 1.66e-05 | 2.07e-04 | 43 |
GO:190136110 | Prostate | BPH | organic cyclic compound catabolic process | 118/3107 | 495/18723 | 1.75e-05 | 2.17e-04 | 118 |
GO:00510516 | Prostate | BPH | negative regulation of transport | 113/3107 | 470/18723 | 1.76e-05 | 2.18e-04 | 113 |
GO:00164855 | Prostate | BPH | protein processing | 62/3107 | 225/18723 | 2.22e-05 | 2.67e-04 | 62 |
GO:003461216 | Prostate | BPH | response to tumor necrosis factor | 68/3107 | 253/18723 | 2.22e-05 | 2.67e-04 | 68 |
GO:005123610 | Prostate | BPH | establishment of RNA localization | 49/3107 | 166/18723 | 2.26e-05 | 2.71e-04 | 49 |
GO:005134616 | Prostate | BPH | negative regulation of hydrolase activity | 94/3107 | 379/18723 | 2.46e-05 | 2.94e-04 | 94 |
GO:00510568 | Prostate | BPH | regulation of small GTPase mediated signal transduction | 78/3107 | 302/18723 | 2.69e-05 | 3.16e-04 | 78 |
GO:005116815 | Prostate | BPH | nuclear export | 46/3107 | 154/18723 | 2.86e-05 | 3.32e-04 | 46 |
GO:003312010 | Prostate | BPH | positive regulation of RNA splicing | 17/3107 | 37/18723 | 2.89e-05 | 3.34e-04 | 17 |
GO:004315415 | Prostate | BPH | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 28/3107 | 78/18723 | 2.91e-05 | 3.34e-04 | 28 |
GO:000862514 | Prostate | BPH | extrinsic apoptotic signaling pathway via death domain receptors | 29/3107 | 82/18723 | 2.92e-05 | 3.34e-04 | 29 |
GO:005065710 | Prostate | BPH | nucleic acid transport | 48/3107 | 163/18723 | 2.92e-05 | 3.34e-04 | 48 |
GO:005065810 | Prostate | BPH | RNA transport | 48/3107 | 163/18723 | 2.92e-05 | 3.34e-04 | 48 |
GO:00435429 | Prostate | BPH | endothelial cell migration | 73/3107 | 279/18723 | 3.03e-05 | 3.46e-04 | 73 |
GO:00400135 | Prostate | BPH | negative regulation of locomotion | 96/3107 | 391/18723 | 3.11e-05 | 3.54e-04 | 96 |
GO:00903038 | Prostate | BPH | positive regulation of wound healing | 23/3107 | 59/18723 | 3.28e-05 | 3.69e-04 | 23 |
GO:00518975 | Prostate | BPH | positive regulation of protein kinase B signaling | 38/3107 | 120/18723 | 3.37e-05 | 3.77e-04 | 38 |
GO:00610148 | Prostate | BPH | positive regulation of mRNA catabolic process | 30/3107 | 87/18723 | 3.72e-05 | 4.04e-04 | 30 |
GO:00303365 | Prostate | BPH | negative regulation of cell migration | 86/3107 | 344/18723 | 3.93e-05 | 4.25e-04 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa05012113 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TH | SNV | Missense_Mutation | c.58N>C | p.Glu20Gln | p.E20Q | P07101 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-E2-A1LS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cyclophosphamide | SD | |
TH | SNV | Missense_Mutation | novel | c.307N>A | p.Ala103Thr | p.A103T | P07101 | protein_coding | tolerated(0.31) | benign(0.055) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TH | SNV | Missense_Mutation | rs760640869 | c.374N>T | p.Ser125Leu | p.S125L | P07101 | protein_coding | deleterious(0.01) | benign(0.058) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TH | SNV | Missense_Mutation | c.235N>A | p.Glu79Lys | p.E79K | P07101 | protein_coding | deleterious(0.04) | probably_damaging(0.957) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TH | SNV | Missense_Mutation | rs372409517 | c.677N>T | p.Ser226Leu | p.S226L | P07101 | protein_coding | deleterious(0.01) | possibly_damaging(0.661) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | novel | c.1201N>C | p.Tyr401His | p.Y401H | P07101 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | novel | c.944N>A | p.Gly315Asp | p.G315D | P07101 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TH | SNV | Missense_Mutation | rs757607038 | c.806C>T | p.Thr269Met | p.T269M | P07101 | protein_coding | deleterious(0.04) | possibly_damaging(0.904) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | c.721N>A | p.Ala241Thr | p.A241T | P07101 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TH | SNV | Missense_Mutation | rs200751977 | c.1492G>A | p.Asp498Asn | p.D498N | P07101 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7054 | TH | ENZYME, DRUGGABLE GENOME | L-Phenylalanine | PHENYLALANINE | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | methylphenidate | METHYLPHENIDATE | 26810137 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | metyrosine | METYROSINE | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | EPO | EPOETIN ALFA | 16368081 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | TETRAHYDROBIOPTERIN | SAPROPTERIN | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | SERTRALINE HYDROCHLORIDE | 8629887 | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | DEHYDROEPIANDROSTERONE | PRASTERONE | 8704732 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1200862 | METYROSINE | |
7054 | TH | ENZYME, DRUGGABLE GENOME | IFN | 8724983 | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | DOXYCYCLINE | DOXYCYCLINE | 15585109 |
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