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Gene: TAT |
Gene summary for TAT |
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Gene information | Species | Human | Gene symbol | TAT | Gene ID | 6898 |
Gene name | tyrosine aminotransferase | |
Gene Alias | TAT | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A140VKB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6898 | TAT | NAFLD1 | Human | Liver | NAFLD | 4.94e-17 | 1.55e+00 | -0.04 |
6898 | TAT | S41 | Human | Liver | Cirrhotic | 4.91e-08 | 9.39e-01 | -0.0343 |
6898 | TAT | S43 | Human | Liver | Cirrhotic | 9.02e-05 | 2.24e-01 | -0.0187 |
6898 | TAT | S44 | Human | Liver | HCC | 1.65e-15 | 1.47e+00 | -0.0083 |
6898 | TAT | HCC1_Meng | Human | Liver | HCC | 3.18e-12 | -2.89e-01 | 0.0246 |
6898 | TAT | HCC2_Meng | Human | Liver | HCC | 5.02e-08 | -3.06e-01 | 0.0107 |
6898 | TAT | cirrhotic1 | Human | Liver | Cirrhotic | 2.73e-06 | -2.90e-01 | 0.0202 |
6898 | TAT | cirrhotic2 | Human | Liver | Cirrhotic | 1.92e-03 | -2.62e-01 | 0.0201 |
6898 | TAT | HCC2 | Human | Liver | HCC | 3.75e-04 | 2.29e+00 | 0.5341 |
6898 | TAT | Pt13.b | Human | Liver | HCC | 2.29e-06 | -1.10e-01 | 0.0251 |
6898 | TAT | Pt14.b | Human | Liver | HCC | 1.34e-04 | 6.11e-02 | 0.018 |
6898 | TAT | Pt14.d | Human | Liver | HCC | 2.29e-05 | -2.81e-01 | 0.0143 |
6898 | TAT | S016 | Human | Liver | HCC | 5.80e-04 | -3.06e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0052548113 | Thyroid | PTC | regulation of endopeptidase activity | 174/5968 | 432/18723 | 1.20e-04 | 9.55e-04 | 174 |
GO:00603377 | Thyroid | PTC | type I interferon signaling pathway | 29/5968 | 50/18723 | 1.21e-04 | 9.66e-04 | 29 |
GO:000283114 | Thyroid | PTC | regulation of response to biotic stimulus | 136/5968 | 327/18723 | 1.22e-04 | 9.69e-04 | 136 |
GO:004639024 | Thyroid | PTC | ribose phosphate biosynthetic process | 85/5968 | 190/18723 | 1.30e-04 | 1.03e-03 | 85 |
GO:0006096110 | Thyroid | PTC | glycolytic process | 42/5968 | 81/18723 | 1.47e-04 | 1.13e-03 | 42 |
GO:009872710 | Thyroid | PTC | maintenance of cell number | 63/5968 | 134/18723 | 1.73e-04 | 1.32e-03 | 63 |
GO:20007367 | Thyroid | PTC | regulation of stem cell differentiation | 32/5968 | 58/18723 | 2.01e-04 | 1.50e-03 | 32 |
GO:0006757110 | Thyroid | PTC | ATP generation from ADP | 42/5968 | 82/18723 | 2.08e-04 | 1.54e-03 | 42 |
GO:0010950113 | Thyroid | PTC | positive regulation of endopeptidase activity | 80/5968 | 179/18723 | 2.09e-04 | 1.55e-03 | 80 |
GO:000926024 | Thyroid | PTC | ribonucleotide biosynthetic process | 81/5968 | 182/18723 | 2.27e-04 | 1.65e-03 | 81 |
GO:200073716 | Thyroid | PTC | negative regulation of stem cell differentiation | 16/5968 | 23/18723 | 2.31e-04 | 1.67e-03 | 16 |
GO:001605218 | Thyroid | PTC | carbohydrate catabolic process | 70/5968 | 154/18723 | 2.77e-04 | 1.97e-03 | 70 |
GO:0097305113 | Thyroid | PTC | response to alcohol | 107/5968 | 253/18723 | 2.92e-04 | 2.07e-03 | 107 |
GO:00198279 | Thyroid | PTC | stem cell population maintenance | 61/5968 | 131/18723 | 3.01e-04 | 2.12e-03 | 61 |
GO:2000377110 | Thyroid | PTC | regulation of reactive oxygen species metabolic process | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
GO:006014716 | Thyroid | PTC | regulation of posttranscriptional gene silencing | 29/5968 | 52/18723 | 3.09e-04 | 2.15e-03 | 29 |
GO:000609020 | Thyroid | PTC | pyruvate metabolic process | 51/5968 | 106/18723 | 3.47e-04 | 2.39e-03 | 51 |
GO:00609669 | Thyroid | PTC | regulation of gene silencing by RNA | 29/5968 | 53/18723 | 4.76e-04 | 3.13e-03 | 29 |
GO:007252219 | Thyroid | PTC | purine-containing compound biosynthetic process | 86/5968 | 200/18723 | 5.85e-04 | 3.72e-03 | 86 |
GO:004347015 | Thyroid | PTC | regulation of carbohydrate catabolic process | 30/5968 | 56/18723 | 6.17e-04 | 3.91e-03 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAT | SNV | Missense_Mutation | novel | c.533N>G | p.Ser178Cys | p.S178C | P17735 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TAT | SNV | Missense_Mutation | c.1137G>T | p.Glu379Asp | p.E379D | P17735 | protein_coding | tolerated(1) | benign(0.005) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TAT | SNV | Missense_Mutation | c.169N>G | p.Arg57Gly | p.R57G | P17735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
TAT | SNV | Missense_Mutation | c.58N>A | p.Val20Met | p.V20M | P17735 | protein_coding | deleterious_low_confidence(0.01) | benign(0.022) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
TAT | SNV | Missense_Mutation | c.868G>C | p.Gly290Arg | p.G290R | P17735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
TAT | insertion | Frame_Shift_Ins | novel | c.35_36insTGAAACCAAATCCAAACAAAAC | p.Asn13GlufsTer87 | p.N13Efs*87 | P17735 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TAT | insertion | Frame_Shift_Ins | novel | c.1118_1121dupACCT | p.Met375ProfsTer6 | p.M375Pfs*6 | P17735 | protein_coding | TCGA-E9-A22H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
TAT | SNV | Missense_Mutation | novel | c.185A>G | p.Asn62Ser | p.N62S | P17735 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TAT | SNV | Missense_Mutation | c.581G>T | p.Trp194Leu | p.W194L | P17735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
TAT | SNV | Missense_Mutation | c.744N>C | p.Glu248Asp | p.E248D | P17735 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-DR-A0ZL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6898 | TAT | ENZYME | TETRACYCLINE | TETRACYCLINE | 2154 | |
6898 | TAT | ENZYME | PROGESTERONE | PROGESTERONE | 9744518 | |
6898 | TAT | ENZYME | ALBUMIN | ALBUMIN HUMAN | 6127852 | |
6898 | TAT | ENZYME | ANDROGENS | 2882620 | ||
6898 | TAT | ENZYME | MITOMYCIN-C | 610 | ||
6898 | TAT | ENZYME | PREDNISOLONE | PREDNISOLONE | 6127207 | |
6898 | TAT | ENZYME | ENZYME INHIBITOR | 85301 | ||
6898 | TAT | ENZYME | PHENOBARBITAL | PHENOBARBITAL | 1688552 | |
6898 | TAT | ENZYME | VITAMIN A | 8100575 | ||
6898 | TAT | ENZYME | GENISTEIN | GENISTEIN | 9128187 |
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