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Gene: AIP |
Gene summary for AIP |
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Gene information | Species | Human | Gene symbol | AIP | Gene ID | 9049 |
Gene name | aryl hydrocarbon receptor interacting protein | |
Gene Alias | ARA9 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | O00170 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9049 | AIP | LZE2T | Human | Esophagus | ESCC | 7.16e-03 | 3.44e-01 | 0.082 |
9049 | AIP | LZE4T | Human | Esophagus | ESCC | 5.21e-13 | 4.56e-01 | 0.0811 |
9049 | AIP | LZE7T | Human | Esophagus | ESCC | 3.52e-12 | 6.40e-01 | 0.0667 |
9049 | AIP | LZE8T | Human | Esophagus | ESCC | 1.44e-09 | 3.03e-01 | 0.067 |
9049 | AIP | LZE20T | Human | Esophagus | ESCC | 8.87e-12 | 5.75e-01 | 0.0662 |
9049 | AIP | LZE22D1 | Human | Esophagus | HGIN | 5.76e-05 | 1.16e-01 | 0.0595 |
9049 | AIP | LZE22T | Human | Esophagus | ESCC | 1.07e-02 | 6.36e-01 | 0.068 |
9049 | AIP | LZE24T | Human | Esophagus | ESCC | 9.48e-25 | 7.38e-01 | 0.0596 |
9049 | AIP | LZE21T | Human | Esophagus | ESCC | 2.31e-02 | 2.23e-01 | 0.0655 |
9049 | AIP | LZE6T | Human | Esophagus | ESCC | 3.11e-11 | 5.41e-01 | 0.0845 |
9049 | AIP | P1T-E | Human | Esophagus | ESCC | 2.44e-08 | 6.42e-01 | 0.0875 |
9049 | AIP | P2T-E | Human | Esophagus | ESCC | 3.84e-34 | 5.80e-01 | 0.1177 |
9049 | AIP | P4T-E | Human | Esophagus | ESCC | 1.14e-51 | 1.28e+00 | 0.1323 |
9049 | AIP | P5T-E | Human | Esophagus | ESCC | 2.70e-52 | 1.01e+00 | 0.1327 |
9049 | AIP | P8T-E | Human | Esophagus | ESCC | 4.31e-69 | 1.17e+00 | 0.0889 |
9049 | AIP | P9T-E | Human | Esophagus | ESCC | 1.19e-29 | 6.04e-01 | 0.1131 |
9049 | AIP | P10T-E | Human | Esophagus | ESCC | 2.84e-30 | 5.74e-01 | 0.116 |
9049 | AIP | P11T-E | Human | Esophagus | ESCC | 2.80e-20 | 9.70e-01 | 0.1426 |
9049 | AIP | P12T-E | Human | Esophagus | ESCC | 1.62e-44 | 7.04e-01 | 0.1122 |
9049 | AIP | P15T-E | Human | Esophagus | ESCC | 4.79e-40 | 1.19e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014054612 | Thyroid | ATC | defense response to symbiont | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:001714823 | Thyroid | ATC | negative regulation of translation | 107/6293 | 245/18723 | 6.17e-04 | 3.51e-03 | 107 |
GO:00435171 | Thyroid | ATC | positive regulation of DNA damage response, signal transduction by p53 class mediator | 11/6293 | 14/18723 | 7.46e-04 | 4.14e-03 | 11 |
GO:190401921 | Thyroid | ATC | epithelial cell apoptotic process | 58/6293 | 121/18723 | 7.47e-04 | 4.14e-03 | 58 |
GO:190236923 | Thyroid | ATC | negative regulation of RNA catabolic process | 39/6293 | 75/18723 | 7.65e-04 | 4.23e-03 | 39 |
GO:009020012 | Thyroid | ATC | positive regulation of release of cytochrome c from mitochondria | 18/6293 | 28/18723 | 8.70e-04 | 4.72e-03 | 18 |
GO:004586134 | Thyroid | ATC | negative regulation of proteolysis | 146/6293 | 351/18723 | 9.84e-04 | 5.22e-03 | 146 |
GO:003300214 | Thyroid | ATC | muscle cell proliferation | 107/6293 | 248/18723 | 1.03e-03 | 5.47e-03 | 107 |
GO:009019915 | Thyroid | ATC | regulation of release of cytochrome c from mitochondria | 27/6293 | 48/18723 | 1.04e-03 | 5.50e-03 | 27 |
GO:003192911 | Thyroid | ATC | TOR signaling | 59/6293 | 126/18723 | 1.39e-03 | 7.19e-03 | 59 |
GO:190204212 | Thyroid | ATC | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 19/6293 | 31/18723 | 1.45e-03 | 7.47e-03 | 19 |
GO:003320917 | Thyroid | ATC | tumor necrosis factor-mediated signaling pathway | 48/6293 | 99/18723 | 1.51e-03 | 7.70e-03 | 48 |
GO:007064613 | Thyroid | ATC | protein modification by small protein removal | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
GO:00487715 | Thyroid | ATC | tissue remodeling | 78/6293 | 175/18723 | 1.60e-03 | 8.04e-03 | 78 |
GO:005134629 | Thyroid | ATC | negative regulation of hydrolase activity | 155/6293 | 379/18723 | 1.64e-03 | 8.23e-03 | 155 |
GO:00457657 | Thyroid | ATC | regulation of angiogenesis | 141/6293 | 342/18723 | 1.80e-03 | 8.85e-03 | 141 |
GO:004352412 | Thyroid | ATC | negative regulation of neuron apoptotic process | 66/6293 | 145/18723 | 1.86e-03 | 9.11e-03 | 66 |
GO:19013427 | Thyroid | ATC | regulation of vasculature development | 143/6293 | 348/18723 | 1.95e-03 | 9.44e-03 | 143 |
GO:004865916 | Thyroid | ATC | smooth muscle cell proliferation | 81/6293 | 184/18723 | 2.02e-03 | 9.60e-03 | 81 |
GO:004508813 | Thyroid | ATC | regulation of innate immune response | 94/6293 | 218/18723 | 2.05e-03 | 9.71e-03 | 94 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIP | SNV | Missense_Mutation | rs574205552 | c.133G>A | p.Asp45Asn | p.D45N | O00170 | protein_coding | tolerated(0.47) | benign(0) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | c.52N>C | p.Ile18Leu | p.I18L | O00170 | protein_coding | tolerated(1) | benign(0.001) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AIP | SNV | Missense_Mutation | rs4930199 | c.920G>A | p.Arg307Gln | p.R307Q | O00170 | protein_coding | tolerated(0.22) | benign(0.022) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.190N>G | p.Ile64Val | p.I64V | O00170 | protein_coding | tolerated(0.57) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
AIP | SNV | Missense_Mutation | c.504N>T | p.Trp168Cys | p.W168C | O00170 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AIP | SNV | Missense_Mutation | rs752553438 | c.160N>T | p.Arg54Trp | p.R54W | O00170 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.138N>T | p.Glu46Asp | p.E46D | O00170 | protein_coding | tolerated(0.15) | benign(0.011) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
AIP | SNV | Missense_Mutation | novel | c.336N>T | p.Lys112Asn | p.K112N | O00170 | protein_coding | deleterious(0) | benign(0.107) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
AIP | SNV | Missense_Mutation | novel | c.505G>A | p.Ala169Thr | p.A169T | O00170 | protein_coding | tolerated(0.32) | probably_damaging(0.947) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.474G>C | p.Glu158Asp | p.E158D | O00170 | protein_coding | tolerated(0.17) | benign(0.249) | TCGA-CN-4730-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9049 | AIP | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | TCDD | 10986286 |
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