Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2000058210 | Thyroid | ATC | regulation of ubiquitin-dependent protein catabolic process | 116/6293 | 164/18723 | 2.15e-22 | 5.43e-20 | 116 |
GO:0032434210 | Thyroid | ATC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/6293 | 134/18723 | 2.41e-22 | 5.86e-20 | 100 |
GO:0045732210 | Thyroid | ATC | positive regulation of protein catabolic process | 148/6293 | 231/18723 | 1.93e-21 | 4.36e-19 | 148 |
GO:190336434 | Thyroid | ATC | positive regulation of cellular protein catabolic process | 109/6293 | 155/18723 | 8.26e-21 | 1.49e-18 | 109 |
GO:190180027 | Thyroid | ATC | positive regulation of proteasomal protein catabolic process | 85/6293 | 114/18723 | 3.70e-19 | 5.20e-17 | 85 |
GO:003243627 | Thyroid | ATC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 70/6293 | 90/18723 | 9.72e-18 | 1.10e-15 | 70 |
GO:190305227 | Thyroid | ATC | positive regulation of proteolysis involved in cellular protein catabolic process | 93/6293 | 133/18723 | 1.06e-17 | 1.18e-15 | 93 |
GO:004586234 | Thyroid | ATC | positive regulation of proteolysis | 202/6293 | 372/18723 | 1.07e-16 | 9.42e-15 | 202 |
GO:200006029 | Thyroid | ATC | positive regulation of ubiquitin-dependent protein catabolic process | 77/6293 | 107/18723 | 5.14e-16 | 4.11e-14 | 77 |
GO:0070997210 | Thyroid | ATC | neuron death | 176/6293 | 361/18723 | 1.43e-09 | 3.57e-08 | 176 |
GO:005140227 | Thyroid | ATC | neuron apoptotic process | 120/6293 | 246/18723 | 5.41e-07 | 7.75e-06 | 120 |
GO:000961225 | Thyroid | ATC | response to mechanical stimulus | 105/6293 | 216/18723 | 3.29e-06 | 3.70e-05 | 105 |
GO:0006470111 | Thyroid | ATC | protein dephosphorylation | 129/6293 | 281/18723 | 1.11e-05 | 1.09e-04 | 129 |
GO:000736915 | Thyroid | ATC | gastrulation | 90/6293 | 185/18723 | 1.54e-05 | 1.43e-04 | 90 |
GO:001631117 | Thyroid | ATC | dephosphorylation | 179/6293 | 417/18723 | 3.88e-05 | 3.15e-04 | 179 |
GO:000170612 | Thyroid | ATC | endoderm formation | 32/6293 | 54/18723 | 9.72e-05 | 7.10e-04 | 32 |
GO:000749222 | Thyroid | ATC | endoderm development | 42/6293 | 77/18723 | 1.24e-04 | 8.82e-04 | 42 |
GO:000170414 | Thyroid | ATC | formation of primary germ layer | 60/6293 | 121/18723 | 1.96e-04 | 1.31e-03 | 60 |
GO:004340926 | Thyroid | ATC | negative regulation of MAPK cascade | 82/6293 | 180/18723 | 5.51e-04 | 3.19e-03 | 82 |
GO:007064613 | Thyroid | ATC | protein modification by small protein removal | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP5 | SNV | Missense_Mutation | | c.103N>A | p.Asp35Asn | p.D35N | P45974 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP5 | SNV | Missense_Mutation | | c.891N>C | p.Glu297Asp | p.E297D | P45974 | protein_coding | tolerated(0.09) | benign(0.031) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP5 | SNV | Missense_Mutation | rs782807103 | c.221G>A | p.Arg74Gln | p.R74Q | P45974 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP5 | SNV | Missense_Mutation | | c.1725N>T | p.Lys575Asn | p.K575N | P45974 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
USP5 | SNV | Missense_Mutation | novel | c.334N>C | p.Glu112Gln | p.E112Q | P45974 | protein_coding | tolerated(0.37) | possibly_damaging(0.672) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP5 | insertion | Frame_Shift_Ins | novel | c.339_340insGAAACCAGCCTGGGCAATATGGCAAGACCTCATC | p.Phe114GlufsTer13 | p.F114Efs*13 | P45974 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP5 | insertion | Nonsense_Mutation | novel | c.480_481insCCATTCTGACCTCCTATTGGACTCAGTTTCTTTTTTTCACCTACT | p.Ala160_Ser161insProPheTerProProIleGlyLeuSerPhePhePheSerProThr | p.A160_S161insPF*PPIGLSFFFSPT | P45974 | protein_coding | | | TCGA-A8-A08Z-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USP5 | deletion | Frame_Shift_Del | novel | c.851_852delNN | p.Leu284GlnfsTer11 | p.L284Qfs*11 | P45974 | protein_coding | | | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
USP5 | deletion | Frame_Shift_Del | | c.1931delN | p.Pro645LeufsTer45 | p.P645Lfs*45 | P45974 | protein_coding | | | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
USP5 | SNV | Missense_Mutation | novel | c.907N>T | p.Arg303Trp | p.R303W | P45974 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |