Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SRSF1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SRSF1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SRSF1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SRSF1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SRSF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SRSF1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SRSF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SRSF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434848 | Lung | IAC | regulation of RNA splicing | 49/2061 | 148/18723 | 4.76e-13 | 7.06e-10 | 49 |
GO:19033117 | Lung | IAC | regulation of mRNA metabolic process | 71/2061 | 288/18723 | 3.76e-11 | 1.24e-08 | 71 |
GO:00480248 | Lung | IAC | regulation of mRNA splicing, via spliceosome | 34/2061 | 101/18723 | 1.05e-09 | 1.95e-07 | 34 |
GO:00506847 | Lung | IAC | regulation of mRNA processing | 41/2061 | 137/18723 | 1.23e-09 | 2.15e-07 | 41 |
GO:00331198 | Lung | IAC | negative regulation of RNA splicing | 12/2061 | 25/18723 | 4.03e-06 | 1.66e-04 | 12 |
GO:00164826 | Lung | IAC | cytosolic transport | 37/2061 | 168/18723 | 2.74e-05 | 7.26e-04 | 37 |
GO:00718268 | Lung | IAC | ribonucleoprotein complex subunit organization | 46/2061 | 227/18723 | 3.02e-05 | 7.79e-04 | 46 |
GO:00083808 | Lung | IAC | RNA splicing | 75/2061 | 434/18723 | 4.89e-05 | 1.12e-03 | 75 |
GO:00226188 | Lung | IAC | ribonucleoprotein complex assembly | 44/2061 | 220/18723 | 6.16e-05 | 1.34e-03 | 44 |
GO:19033128 | Lung | IAC | negative regulation of mRNA metabolic process | 22/2061 | 92/18723 | 3.30e-04 | 5.19e-03 | 22 |
GO:00003778 | Lung | IAC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 52/2061 | 320/18723 | 2.64e-03 | 2.44e-02 | 52 |
GO:00003988 | Lung | IAC | mRNA splicing, via spliceosome | 52/2061 | 320/18723 | 2.64e-03 | 2.44e-02 | 52 |
GO:00003758 | Lung | IAC | RNA splicing, via transesterification reactions | 52/2061 | 324/18723 | 3.43e-03 | 2.93e-02 | 52 |
GO:00480254 | Lung | IAC | negative regulation of mRNA splicing, via spliceosome | 7/2061 | 20/18723 | 4.11e-03 | 3.32e-02 | 7 |
GO:004348413 | Lung | AIS | regulation of RNA splicing | 45/1849 | 148/18723 | 2.75e-12 | 2.67e-09 | 45 |
GO:004802413 | Lung | AIS | regulation of mRNA splicing, via spliceosome | 32/1849 | 101/18723 | 1.20e-09 | 2.42e-07 | 32 |
GO:190331112 | Lung | AIS | regulation of mRNA metabolic process | 60/1849 | 288/18723 | 1.74e-08 | 2.47e-06 | 60 |
GO:005068412 | Lung | AIS | regulation of mRNA processing | 36/1849 | 137/18723 | 3.06e-08 | 3.79e-06 | 36 |
GO:003311913 | Lung | AIS | negative regulation of RNA splicing | 11/1849 | 25/18723 | 1.02e-05 | 4.19e-04 | 11 |
GO:001648212 | Lung | AIS | cytosolic transport | 35/1849 | 168/18723 | 1.57e-05 | 5.63e-04 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRSF1 | SNV | Missense_Mutation | novel | c.427N>A | p.Glu143Lys | p.E143K | Q07955 | protein_coding | tolerated(0.36) | probably_damaging(0.969) | TCGA-PE-A5DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | CR |
SRSF1 | insertion | Frame_Shift_Ins | novel | c.581_582insCATAGCAGATCTCGCTCTCGTACATAAGATGATTGGTG | p.Asp195IlefsTer106 | p.D195Ifs*106 | Q07955 | protein_coding | | | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
SRSF1 | SNV | Missense_Mutation | | c.158N>A | p.Gly53Glu | p.G53E | Q07955 | protein_coding | tolerated(0.24) | possibly_damaging(0.893) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SRSF1 | SNV | Missense_Mutation | | c.416A>G | p.Asp139Gly | p.D139G | Q07955 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EX-A69M-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SRSF1 | SNV | Missense_Mutation | novel | c.405N>T | p.Gln135His | p.Q135H | Q07955 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SRSF1 | SNV | Missense_Mutation | | c.229T>A | p.Tyr77Asn | p.Y77N | Q07955 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SRSF1 | SNV | Missense_Mutation | | c.414N>T | p.Lys138Asn | p.K138N | Q07955 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
SRSF1 | SNV | Missense_Mutation | | c.731C>A | p.Ser244Tyr | p.S244Y | Q07955 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.831) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
SRSF1 | SNV | Missense_Mutation | | c.478G>A | p.Val160Met | p.V160M | Q07955 | protein_coding | deleterious(0.01) | probably_damaging(0.955) | TCGA-BG-A0M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SRSF1 | SNV | Missense_Mutation | novel | c.581N>C | p.Val194Ala | p.V194A | Q07955 | protein_coding | tolerated(0.65) | benign(0.011) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |