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Gene: SNAI2 |
Gene summary for SNAI2 |
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Gene information | Species | Human | Gene symbol | SNAI2 | Gene ID | 6591 |
Gene name | snail family transcriptional repressor 2 | |
Gene Alias | SLUG | |
Cytomap | 8q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O43623 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6591 | SNAI2 | LZE4T | Human | Esophagus | ESCC | 7.04e-08 | 5.18e-01 | 0.0811 |
6591 | SNAI2 | P2T-E | Human | Esophagus | ESCC | 8.09e-25 | 6.78e-01 | 0.1177 |
6591 | SNAI2 | P4T-E | Human | Esophagus | ESCC | 2.85e-06 | 4.37e-01 | 0.1323 |
6591 | SNAI2 | P5T-E | Human | Esophagus | ESCC | 1.69e-14 | 3.65e-01 | 0.1327 |
6591 | SNAI2 | P8T-E | Human | Esophagus | ESCC | 7.07e-03 | -1.94e-02 | 0.0889 |
6591 | SNAI2 | P9T-E | Human | Esophagus | ESCC | 4.77e-13 | 6.01e-01 | 0.1131 |
6591 | SNAI2 | P10T-E | Human | Esophagus | ESCC | 2.78e-26 | 7.35e-01 | 0.116 |
6591 | SNAI2 | P11T-E | Human | Esophagus | ESCC | 4.46e-06 | 1.04e+00 | 0.1426 |
6591 | SNAI2 | P12T-E | Human | Esophagus | ESCC | 3.92e-11 | 5.65e-01 | 0.1122 |
6591 | SNAI2 | P15T-E | Human | Esophagus | ESCC | 1.80e-18 | 7.42e-01 | 0.1149 |
6591 | SNAI2 | P16T-E | Human | Esophagus | ESCC | 1.49e-41 | 1.16e+00 | 0.1153 |
6591 | SNAI2 | P20T-E | Human | Esophagus | ESCC | 7.73e-19 | 7.65e-01 | 0.1124 |
6591 | SNAI2 | P21T-E | Human | Esophagus | ESCC | 3.58e-26 | 1.07e+00 | 0.1617 |
6591 | SNAI2 | P22T-E | Human | Esophagus | ESCC | 1.94e-34 | 9.31e-01 | 0.1236 |
6591 | SNAI2 | P23T-E | Human | Esophagus | ESCC | 6.10e-10 | 8.17e-01 | 0.108 |
6591 | SNAI2 | P26T-E | Human | Esophagus | ESCC | 2.56e-26 | 8.40e-01 | 0.1276 |
6591 | SNAI2 | P27T-E | Human | Esophagus | ESCC | 3.40e-14 | 3.81e-01 | 0.1055 |
6591 | SNAI2 | P28T-E | Human | Esophagus | ESCC | 4.22e-07 | 3.55e-01 | 0.1149 |
6591 | SNAI2 | P30T-E | Human | Esophagus | ESCC | 8.36e-41 | 2.05e+00 | 0.137 |
6591 | SNAI2 | P31T-E | Human | Esophagus | ESCC | 3.75e-24 | 7.89e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007233119 | Prostate | Tumor | signal transduction by p53 class mediator | 63/3246 | 163/18723 | 7.82e-11 | 4.96e-09 | 63 |
GO:001605514 | Prostate | Tumor | Wnt signaling pathway | 131/3246 | 444/18723 | 1.16e-10 | 7.11e-09 | 131 |
GO:019873814 | Prostate | Tumor | cell-cell signaling by wnt | 131/3246 | 446/18723 | 1.61e-10 | 9.69e-09 | 131 |
GO:200123619 | Prostate | Tumor | regulation of extrinsic apoptotic signaling pathway | 59/3246 | 151/18723 | 1.86e-10 | 1.09e-08 | 59 |
GO:000164915 | Prostate | Tumor | osteoblast differentiation | 77/3246 | 229/18723 | 1.55e-09 | 7.26e-08 | 77 |
GO:005067316 | Prostate | Tumor | epithelial cell proliferation | 125/3246 | 437/18723 | 2.56e-09 | 1.08e-07 | 125 |
GO:003011114 | Prostate | Tumor | regulation of Wnt signaling pathway | 99/3246 | 328/18723 | 5.92e-09 | 2.34e-07 | 99 |
GO:200124319 | Prostate | Tumor | negative regulation of intrinsic apoptotic signaling pathway | 41/3246 | 98/18723 | 1.06e-08 | 3.88e-07 | 41 |
GO:005067815 | Prostate | Tumor | regulation of epithelial cell proliferation | 110/3246 | 381/18723 | 1.32e-08 | 4.82e-07 | 110 |
GO:003166818 | Prostate | Tumor | cellular response to extracellular stimulus | 78/3246 | 246/18723 | 2.34e-08 | 8.08e-07 | 78 |
GO:006082814 | Prostate | Tumor | regulation of canonical Wnt signaling pathway | 79/3246 | 253/18723 | 4.01e-08 | 1.25e-06 | 79 |
GO:007084915 | Prostate | Tumor | response to epidermal growth factor | 25/3246 | 49/18723 | 7.26e-08 | 2.04e-06 | 25 |
GO:003052217 | Prostate | Tumor | intracellular receptor signaling pathway | 81/3246 | 265/18723 | 7.65e-08 | 2.14e-06 | 81 |
GO:190179619 | Prostate | Tumor | regulation of signal transduction by p53 class mediator | 38/3246 | 93/18723 | 7.68e-08 | 2.14e-06 | 38 |
GO:002241118 | Prostate | Tumor | cellular component disassembly | 121/3246 | 443/18723 | 8.10e-08 | 2.23e-06 | 121 |
GO:003166719 | Prostate | Tumor | response to nutrient levels | 127/3246 | 474/18723 | 1.27e-07 | 3.28e-06 | 127 |
GO:007136415 | Prostate | Tumor | cellular response to epidermal growth factor stimulus | 23/3246 | 45/18723 | 2.32e-07 | 5.52e-06 | 23 |
GO:003432915 | Prostate | Tumor | cell junction assembly | 113/3246 | 420/18723 | 4.94e-07 | 1.07e-05 | 113 |
GO:006007014 | Prostate | Tumor | canonical Wnt signaling pathway | 87/3246 | 303/18723 | 5.49e-07 | 1.17e-05 | 87 |
GO:003166917 | Prostate | Tumor | cellular response to nutrient levels | 66/3246 | 215/18723 | 1.00e-06 | 1.94e-05 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0452029 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa04520113 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439010 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa04520112 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439015 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa0452028 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439024 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
hsa0452036 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439034 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNAI2 | SNV | Missense_Mutation | novel | c.709N>A | p.Asp237Asn | p.D237N | O43623 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | novel | c.750N>A | p.Phe250Leu | p.F250L | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | novel | c.473N>A | p.Ser158Tyr | p.S158Y | O43623 | protein_coding | tolerated(1) | benign(0.025) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | novel | c.373N>A | p.Ala125Thr | p.A125T | O43623 | protein_coding | tolerated(0.11) | benign(0.283) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | c.89C>T | p.Ser30Phe | p.S30F | O43623 | protein_coding | tolerated(0.65) | possibly_damaging(0.459) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SNAI2 | SNV | Missense_Mutation | novel | c.783N>T | p.Glu261Asp | p.E261D | O43623 | protein_coding | tolerated(0.1) | benign(0.062) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SNAI2 | SNV | Missense_Mutation | c.422N>T | p.Ser141Phe | p.S141F | O43623 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNAI2 | SNV | Missense_Mutation | novel | c.359C>T | p.Pro120Leu | p.P120L | O43623 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | novel | c.750C>A | p.Phe250Leu | p.F250L | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | c.83N>G | p.Ile28Ser | p.I28S | O43623 | protein_coding | tolerated(0.5) | benign(0.006) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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