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Gene: SLC39A1 |
Gene summary for SLC39A1 |
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Gene information | Species | Human | Gene symbol | SLC39A1 | Gene ID | 27173 |
Gene name | solute carrier family 39 member 1 | |
Gene Alias | ZIP1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q9NY26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27173 | SLC39A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.54e-08 | 1.38e-01 | 0.0155 |
27173 | SLC39A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.44e-06 | 2.85e-01 | -0.1808 |
27173 | SLC39A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.00e-15 | 4.68e-01 | -0.0811 |
27173 | SLC39A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.12e-10 | 2.74e-01 | -0.1088 |
27173 | SLC39A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.50e-15 | 3.45e-01 | -0.1954 |
27173 | SLC39A1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.15e-05 | 7.43e-01 | -0.2602 |
27173 | SLC39A1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.31e-02 | 3.36e-01 | -0.2196 |
27173 | SLC39A1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.54e-04 | 2.58e-01 | -0.1207 |
27173 | SLC39A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.20e-04 | 1.87e-01 | -0.1526 |
27173 | SLC39A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.61e-16 | 3.47e-01 | -0.1464 |
27173 | SLC39A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.96e-05 | 2.28e-01 | -0.1001 |
27173 | SLC39A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.79e-19 | 5.23e-01 | -0.059 |
27173 | SLC39A1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.19e-06 | 5.15e-01 | -0.1706 |
27173 | SLC39A1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.76e-04 | 2.70e-01 | -0.2061 |
27173 | SLC39A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.67e-22 | 4.74e-01 | 0.096 |
27173 | SLC39A1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.61e-05 | 3.58e-01 | 0.0446 |
27173 | SLC39A1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.17e-04 | 2.36e-01 | 0.0528 |
27173 | SLC39A1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.84e-03 | 3.04e-01 | 0.0131 |
27173 | SLC39A1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.76e-06 | 2.87e-01 | -0.0177 |
27173 | SLC39A1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.32e-06 | 2.36e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004691614 | Prostate | Tumor | cellular transition metal ion homeostasis | 37/3246 | 115/18723 | 7.56e-05 | 7.88e-04 | 37 |
GO:004366616 | Prostate | Tumor | regulation of phosphoprotein phosphatase activity | 22/3246 | 58/18723 | 1.53e-04 | 1.39e-03 | 22 |
GO:003530318 | Prostate | Tumor | regulation of dephosphorylation | 39/3246 | 128/18723 | 1.82e-04 | 1.60e-03 | 39 |
GO:001092113 | Prostate | Tumor | regulation of phosphatase activity | 28/3246 | 84/18723 | 2.80e-04 | 2.28e-03 | 28 |
GO:001631113 | Prostate | Tumor | dephosphorylation | 98/3246 | 417/18723 | 7.31e-04 | 5.08e-03 | 98 |
GO:003530711 | Prostate | Tumor | positive regulation of protein dephosphorylation | 17/3246 | 45/18723 | 8.86e-04 | 5.92e-03 | 17 |
GO:003251611 | Prostate | Tumor | positive regulation of phosphoprotein phosphatase activity | 10/3246 | 21/18723 | 1.33e-03 | 8.31e-03 | 10 |
GO:003530611 | Prostate | Tumor | positive regulation of dephosphorylation | 20/3246 | 59/18723 | 1.58e-03 | 9.63e-03 | 20 |
GO:001092212 | Prostate | Tumor | positive regulation of phosphatase activity | 13/3246 | 34/18723 | 3.09e-03 | 1.63e-02 | 13 |
GO:005085411 | Prostate | Tumor | regulation of antigen receptor-mediated signaling pathway | 19/3246 | 63/18723 | 8.63e-03 | 3.75e-02 | 19 |
GO:007066314 | Prostate | Tumor | regulation of leukocyte proliferation | 57/3246 | 245/18723 | 1.04e-02 | 4.36e-02 | 57 |
GO:000170124 | Skin | cSCC | in utero embryonic development | 150/4864 | 367/18723 | 2.47e-10 | 1.04e-08 | 150 |
GO:000647024 | Skin | cSCC | protein dephosphorylation | 111/4864 | 281/18723 | 4.10e-07 | 7.96e-06 | 111 |
GO:001003829 | Skin | cSCC | response to metal ion | 132/4864 | 373/18723 | 3.11e-05 | 3.42e-04 | 132 |
GO:0035304112 | Skin | cSCC | regulation of protein dephosphorylation | 41/4864 | 90/18723 | 4.61e-05 | 4.80e-04 | 41 |
GO:005507618 | Skin | cSCC | transition metal ion homeostasis | 57/4864 | 138/18723 | 5.96e-05 | 5.86e-04 | 57 |
GO:004691610 | Skin | cSCC | cellular transition metal ion homeostasis | 48/4864 | 115/18723 | 1.63e-04 | 1.43e-03 | 48 |
GO:0035303112 | Skin | cSCC | regulation of dephosphorylation | 49/4864 | 128/18723 | 1.46e-03 | 9.17e-03 | 49 |
GO:001631115 | Skin | cSCC | dephosphorylation | 134/4864 | 417/18723 | 2.65e-03 | 1.50e-02 | 134 |
GO:00068826 | Skin | cSCC | cellular zinc ion homeostasis | 17/4864 | 38/18723 | 9.41e-03 | 4.25e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050124 | Colorectum | MSS | Parkinson disease | 140/1875 | 266/8465 | 2.32e-28 | 7.79e-26 | 4.77e-26 | 140 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050125 | Colorectum | MSS | Parkinson disease | 140/1875 | 266/8465 | 2.32e-28 | 7.79e-26 | 4.77e-26 | 140 |
hsa050105 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0501214 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501215 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC39A1 | SNV | Missense_Mutation | c.14G>A | p.Gly5Glu | p.G5E | Q9NY26 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC39A1 | SNV | Missense_Mutation | c.118N>T | p.Leu40Phe | p.L40F | Q9NY26 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SLC39A1 | SNV | Missense_Mutation | novel | c.883G>C | p.Glu295Gln | p.E295Q | Q9NY26 | protein_coding | tolerated(0.06) | probably_damaging(0.976) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC39A1 | SNV | Missense_Mutation | novel | c.536N>A | p.Arg179His | p.R179H | Q9NY26 | protein_coding | deleterious(0) | possibly_damaging(0.777) | TCGA-AJ-A3BK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC39A1 | SNV | Missense_Mutation | c.244N>A | p.Ala82Thr | p.A82T | Q9NY26 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC39A1 | SNV | Missense_Mutation | novel | c.535N>T | p.Arg179Cys | p.R179C | Q9NY26 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC39A1 | SNV | Missense_Mutation | novel | c.503N>T | p.Ala168Val | p.A168V | Q9NY26 | protein_coding | tolerated(0.39) | benign(0.058) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SLC39A1 | SNV | Missense_Mutation | novel | c.770G>A | p.Gly257Asp | p.G257D | Q9NY26 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-6987-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC39A1 | SNV | Missense_Mutation | novel | c.294N>T | p.Glu98Asp | p.E98D | Q9NY26 | protein_coding | tolerated(0.45) | benign(0.066) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC39A1 | SNV | Missense_Mutation | c.901N>G | p.Gln301Glu | p.Q301E | Q9NY26 | protein_coding | tolerated(0.62) | benign(0.089) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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