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Gene: SELE |
Gene summary for SELE |
Gene summary. |
Gene information | Species | Human | Gene symbol | SELE | Gene ID | 6401 |
Gene name | selectin E | |
Gene Alias | CD62E | |
Cytomap | 1q24.2 | |
Gene Type | protein-coding | GO ID | GO:0002090 | UniProtAcc | P16581 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6401 | SELE | P2T-E | Human | Esophagus | ESCC | 2.96e-09 | 9.01e-01 | 0.1177 |
6401 | SELE | P38T-E | Human | Esophagus | ESCC | 3.60e-04 | 2.01e-01 | 0.127 |
6401 | SELE | P61T-E | Human | Esophagus | ESCC | 1.63e-06 | 6.22e-02 | 0.099 |
6401 | SELE | P80T-E | Human | Esophagus | ESCC | 2.02e-02 | 5.43e-02 | 0.155 |
6401 | SELE | P127T-E | Human | Esophagus | ESCC | 7.96e-04 | 2.63e-02 | 0.0826 |
6401 | SELE | P128T-E | Human | Esophagus | ESCC | 5.36e-31 | 1.16e+00 | 0.1241 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:003462010 | Cervix | CC | cellular response to unfolded protein | 27/2311 | 96/18723 | 2.53e-05 | 4.29e-04 | 27 |
GO:00706617 | Cervix | CC | leukocyte proliferation | 65/2311 | 318/18723 | 2.56e-05 | 4.32e-04 | 65 |
GO:00507273 | Cervix | CC | regulation of inflammatory response | 75/2311 | 386/18723 | 3.95e-05 | 6.18e-04 | 75 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
GO:00466516 | Cervix | CC | lymphocyte proliferation | 59/2311 | 288/18723 | 5.53e-05 | 8.10e-04 | 59 |
GO:00716775 | Cervix | CC | positive regulation of mononuclear cell migration | 20/2311 | 65/18723 | 6.96e-05 | 9.81e-04 | 20 |
GO:00457306 | Cervix | CC | respiratory burst | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:000974310 | Cervix | CC | response to carbohydrate | 53/2311 | 253/18723 | 7.02e-05 | 9.85e-04 | 53 |
GO:00069846 | Cervix | CC | ER-nucleus signaling pathway | 16/2311 | 46/18723 | 7.12e-05 | 9.90e-04 | 16 |
GO:00329435 | Cervix | CC | mononuclear cell proliferation | 59/2311 | 291/18723 | 7.51e-05 | 1.03e-03 | 59 |
GO:00972379 | Cervix | CC | cellular response to toxic substance | 31/2311 | 124/18723 | 8.09e-05 | 1.10e-03 | 31 |
GO:003428410 | Cervix | CC | response to monosaccharide | 48/2311 | 225/18723 | 9.48e-05 | 1.25e-03 | 48 |
GO:003596710 | Cervix | CC | cellular response to topologically incorrect protein | 29/2311 | 116/18723 | 1.35e-04 | 1.66e-03 | 29 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00713757 | Cervix | CC | cellular response to peptide hormone stimulus | 57/2311 | 290/18723 | 2.32e-04 | 2.59e-03 | 57 |
GO:19022356 | Cervix | CC | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 12/2311 | 32/18723 | 2.53e-04 | 2.79e-03 | 12 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00507773 | Cervix | CC | negative regulation of immune response | 41/2311 | 194/18723 | 3.63e-04 | 3.76e-03 | 41 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa0493310 | Esophagus | ESCC | AGE-RAGE signaling pathway in diabetic complications | 72/4205 | 100/8465 | 4.15e-06 | 2.28e-05 | 1.17e-05 | 72 |
hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0466817 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa05417310 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa0493317 | Esophagus | ESCC | AGE-RAGE signaling pathway in diabetic complications | 72/4205 | 100/8465 | 4.15e-06 | 2.28e-05 | 1.17e-05 | 72 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SELE | CD44 | SELE_CD44 | SELE | Breast | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | ADJ |
SELPLG | SELE | SELPLG_SELE | SELPLG | Breast | ADJ |
SELE | CD44 | SELE_CD44 | SELE | Breast | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | Healthy |
SELPLG | SELE | SELPLG_SELE | SELPLG | Breast | Healthy |
SELE | CEACAM1 | SELE_CEACAM1 | CEACAM | Breast | Healthy |
SELE | CD44 | SELE_CD44 | SELE | Breast | Precancer |
SELE | CD44 | SELE_CD44 | SELE | Cervix | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | ADJ |
SELPLG | SELE | SELPLG_SELE | SELPLG | Cervix | ADJ |
SELE | CD44 | SELE_CD44 | SELE | Cervix | CC |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | CC |
SELE | CEACAM1 | SELE_CEACAM1 | CEACAM | Cervix | CC |
SELPLG | SELE | SELPLG_SELE | SELPLG | Cervix | CC |
SELE | CD44 | SELE_CD44 | SELE | Endometrium | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | ADJ |
SELPLG | SELE | SELPLG_SELE | SELPLG | Endometrium | ADJ |
SELE | CD44 | SELE_CD44 | SELE | Endometrium | AEH |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | AEH |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELE | SNV | Missense_Mutation | c.80N>G | p.Ser27Cys | p.S27C | P16581 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SELE | SNV | Missense_Mutation | novel | c.464N>G | p.Val155Gly | p.V155G | P16581 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SELE | insertion | In_Frame_Ins | novel | c.465_466insACT | p.Val155_Glu156insThr | p.V155_E156insT | P16581 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
SELE | SNV | Missense_Mutation | c.1681N>T | p.Leu561Phe | p.L561F | P16581 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
SELE | SNV | Missense_Mutation | c.113N>A | p.Ala38Asp | p.A38D | P16581 | protein_coding | tolerated(0.57) | benign(0.009) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SELE | SNV | Missense_Mutation | novel | c.518A>G | p.Lys173Arg | p.K173R | P16581 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
SELE | SNV | Missense_Mutation | c.1408N>G | p.Ser470Ala | p.S470A | P16581 | protein_coding | tolerated(0.13) | benign(0.217) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SELE | SNV | Missense_Mutation | c.113N>T | p.Ala38Val | p.A38V | P16581 | protein_coding | tolerated(0.25) | benign(0.069) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SELE | SNV | Missense_Mutation | novel | c.544G>A | p.Ala182Thr | p.A182T | P16581 | protein_coding | tolerated(0.24) | possibly_damaging(0.543) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SELE | SNV | Missense_Mutation | c.1758G>T | p.Lys586Asn | p.K586N | P16581 | protein_coding | deleterious(0) | benign(0.42) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | leucovorin | LEUCOVORIN | 24980946 | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | BIMOSIAMOSE | BIMOSIAMOSE | ||
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | fluorouracil | FLUOROURACIL | 24980946 | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | capecitabine | CAPECITABINE | 24980946 | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | CHEMBL1215923 | BIMOSIAMOSE | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | Bimosiamose | BIMOSIAMOSE | ||
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | GMI-1359 | |||
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | GMI-1070 | RIVIPANSEL | 20508165 | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | CHEMBL3707446 | RIVIPANSEL | |
6401 | SELE | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | SIALYL LEWIS X | SIALYL LEWIS X |
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