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Gene: RGS2 |
Gene summary for RGS2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RGS2 | Gene ID | 5997 |
| Gene name | regulator of G protein signaling 2 | |
| Gene Alias | G0S8 | |
| Cytomap | 1q31.2 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R939 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5997 | RGS2 | CA_HPV_1 | Human | Cervix | CC | 1.47e-09 | 5.63e-01 | 0.0264 |
| 5997 | RGS2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 5.45e-07 | -4.49e-01 | 0.0208 |
| 5997 | RGS2 | CCI_1 | Human | Cervix | CC | 9.73e-04 | -7.04e-01 | 0.528 |
| 5997 | RGS2 | CCI_2 | Human | Cervix | CC | 1.72e-04 | -7.43e-01 | 0.5249 |
| 5997 | RGS2 | CCI_3 | Human | Cervix | CC | 2.81e-07 | -7.33e-01 | 0.516 |
| 5997 | RGS2 | CCII_1 | Human | Cervix | CC | 4.27e-14 | -7.65e-01 | 0.3249 |
| 5997 | RGS2 | Tumor | Human | Cervix | CC | 4.47e-16 | -5.82e-01 | 0.1241 |
| 5997 | RGS2 | sample3 | Human | Cervix | CC | 1.87e-16 | -5.59e-01 | 0.1387 |
| 5997 | RGS2 | H2 | Human | Cervix | HSIL_HPV | 5.20e-22 | -6.61e-01 | 0.0632 |
| 5997 | RGS2 | L1 | Human | Cervix | CC | 1.59e-06 | -6.07e-01 | 0.0802 |
| 5997 | RGS2 | T3 | Human | Cervix | CC | 1.06e-16 | -6.00e-01 | 0.1389 |
| 5997 | RGS2 | LZE7T | Human | Esophagus | ESCC | 3.52e-07 | 3.32e-02 | 0.0667 |
| 5997 | RGS2 | LZE8T | Human | Esophagus | ESCC | 1.54e-02 | -2.46e-01 | 0.067 |
| 5997 | RGS2 | LZE21D1 | Human | Esophagus | HGIN | 6.03e-05 | -1.85e-01 | 0.0632 |
| 5997 | RGS2 | LZE24T | Human | Esophagus | ESCC | 2.05e-03 | -8.31e-02 | 0.0596 |
| 5997 | RGS2 | LZE21T | Human | Esophagus | ESCC | 3.37e-02 | -1.36e-01 | 0.0655 |
| 5997 | RGS2 | P2T-E | Human | Esophagus | ESCC | 1.33e-11 | -2.61e-01 | 0.1177 |
| 5997 | RGS2 | P4T-E | Human | Esophagus | ESCC | 5.10e-14 | 8.06e-01 | 0.1323 |
| 5997 | RGS2 | P5T-E | Human | Esophagus | ESCC | 1.59e-36 | 1.15e+00 | 0.1327 |
| 5997 | RGS2 | P8T-E | Human | Esophagus | ESCC | 4.92e-08 | -1.02e-01 | 0.0889 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:006013514 | Prostate | Tumor | maternal process involved in female pregnancy | 20/3246 | 62/18723 | 3.07e-03 | 1.63e-02 | 20 |
| GO:001097611 | Prostate | Tumor | positive regulation of neuron projection development | 42/3246 | 163/18723 | 4.24e-03 | 2.12e-02 | 42 |
| GO:00487382 | Prostate | Tumor | cardiac muscle tissue development | 57/3246 | 236/18723 | 4.67e-03 | 2.29e-02 | 57 |
| GO:00861031 | Prostate | Tumor | G protein-coupled receptor signaling pathway involved in heart process | 7/3246 | 14/18723 | 5.15e-03 | 2.48e-02 | 7 |
| GO:1903959 | Prostate | Tumor | regulation of anion transmembrane transport | 10/3246 | 25/18723 | 6.30e-03 | 2.89e-02 | 10 |
| GO:001407512 | Prostate | Tumor | response to amine | 16/3246 | 49/18723 | 6.74e-03 | 3.07e-02 | 16 |
| GO:00550011 | Prostate | Tumor | muscle cell development | 45/3246 | 184/18723 | 8.73e-03 | 3.78e-02 | 45 |
| GO:00030183 | Prostate | Tumor | vascular process in circulatory system | 61/3246 | 263/18723 | 8.88e-03 | 3.84e-02 | 61 |
| GO:004863813 | Prostate | Tumor | regulation of developmental growth | 74/3246 | 330/18723 | 1.00e-02 | 4.20e-02 | 74 |
| GO:000641730 | Thyroid | HT | regulation of translation | 78/1272 | 468/18723 | 1.12e-13 | 2.83e-11 | 78 |
| GO:006053718 | Thyroid | HT | muscle tissue development | 62/1272 | 403/18723 | 1.10e-09 | 1.20e-07 | 62 |
| GO:005134830 | Thyroid | HT | negative regulation of transferase activity | 45/1272 | 268/18723 | 1.49e-08 | 1.20e-06 | 45 |
| GO:001470610 | Thyroid | HT | striated muscle tissue development | 55/1272 | 384/18723 | 1.16e-07 | 6.59e-06 | 55 |
| GO:005134628 | Thyroid | HT | negative regulation of hydrolase activity | 54/1272 | 379/18723 | 1.80e-07 | 9.53e-06 | 54 |
| GO:000646924 | Thyroid | HT | negative regulation of protein kinase activity | 33/1272 | 212/18723 | 6.62e-06 | 1.95e-04 | 33 |
| GO:00342498 | Thyroid | HT | negative regulation of cellular amide metabolic process | 39/1272 | 273/18723 | 8.37e-06 | 2.34e-04 | 39 |
| GO:003367324 | Thyroid | HT | negative regulation of kinase activity | 35/1272 | 237/18723 | 1.16e-05 | 3.05e-04 | 35 |
| GO:00426929 | Thyroid | HT | muscle cell differentiation | 49/1272 | 384/18723 | 1.52e-05 | 3.78e-04 | 49 |
| GO:000193327 | Thyroid | HT | negative regulation of protein phosphorylation | 45/1272 | 342/18723 | 1.54e-05 | 3.80e-04 | 45 |
| GO:001604926 | Thyroid | HT | cell growth | 58/1272 | 482/18723 | 1.56e-05 | 3.82e-04 | 58 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa049218 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
| hsa0492111 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
| hsa049219 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
| hsa040224 | Oral cavity | EOLP | cGMP-PKG signaling pathway | 36/1218 | 167/8465 | 7.34e-03 | 2.12e-02 | 1.25e-02 | 36 |
| hsa0492112 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
| hsa0402211 | Oral cavity | EOLP | cGMP-PKG signaling pathway | 36/1218 | 167/8465 | 7.34e-03 | 2.12e-02 | 1.25e-02 | 36 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RGS2 | SNV | Missense_Mutation | rs759895235 | c.518C>T | p.Ala173Val | p.A173V | P41220 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RGS2 | SNV | Missense_Mutation | c.93A>C | p.Glu31Asp | p.E31D | P41220 | protein_coding | tolerated(0.45) | benign(0.099) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| RGS2 | SNV | Missense_Mutation | c.349G>A | p.Glu117Lys | p.E117K | P41220 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| RGS2 | SNV | Missense_Mutation | c.300N>G | p.Phe100Leu | p.F100L | P41220 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
| RGS2 | SNV | Missense_Mutation | c.595T>A | p.Cys199Ser | p.C199S | P41220 | protein_coding | deleterious(0) | possibly_damaging(0.447) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| RGS2 | SNV | Missense_Mutation | rs149228054 | c.315C>A | p.Phe105Leu | p.F105L | P41220 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RGS2 | SNV | Missense_Mutation | novel | c.247G>T | p.Ala83Ser | p.A83S | P41220 | protein_coding | tolerated(1) | benign(0.013) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| RGS2 | insertion | Frame_Shift_Ins | rs775439827 | c.183_184insA | p.Ser64LysfsTer12 | p.S64Kfs*12 | P41220 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
| RGS2 | SNV | Missense_Mutation | novel | c.445N>G | p.Asn149Asp | p.N149D | P41220 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RGS2 | SNV | Missense_Mutation | rs149228054 | c.315N>A | p.Phe105Leu | p.F105L | P41220 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 5997 | RGS2 | NA | haloperidol | HALOPERIDOL | 27023437 | |
| 5997 | RGS2 | NA | antipsychotics | 18347610 |
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