Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PPFIA1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PPFIA1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PPFIA1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPFIA1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PPFIA1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPFIA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PPFIA1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PPFIA1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PPFIA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00514976 | Prostate | BPH | negative regulation of stress fiber assembly | 14/3107 | 32/18723 | 2.77e-04 | 2.16e-03 | 14 |
GO:00322326 | Prostate | BPH | negative regulation of actin filament bundle assembly | 14/3107 | 35/18723 | 8.33e-04 | 5.41e-03 | 14 |
GO:19030776 | Prostate | BPH | negative regulation of protein localization to plasma membrane | 9/3107 | 24/18723 | 1.14e-02 | 4.64e-02 | 9 |
GO:190290319 | Prostate | Tumor | regulation of supramolecular fiber organization | 131/3246 | 383/18723 | 6.68e-16 | 1.26e-13 | 131 |
GO:003297019 | Prostate | Tumor | regulation of actin filament-based process | 133/3246 | 397/18723 | 2.59e-15 | 4.35e-13 | 133 |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:003295619 | Prostate | Tumor | regulation of actin cytoskeleton organization | 117/3246 | 358/18723 | 8.34e-13 | 8.22e-11 | 117 |
GO:005101719 | Prostate | Tumor | actin filament bundle assembly | 63/3246 | 157/18723 | 1.18e-11 | 9.07e-10 | 63 |
GO:011005319 | Prostate | Tumor | regulation of actin filament organization | 94/3246 | 278/18723 | 1.77e-11 | 1.25e-09 | 94 |
GO:006157219 | Prostate | Tumor | actin filament bundle organization | 63/3246 | 161/18723 | 4.23e-11 | 2.82e-09 | 63 |
GO:003158916 | Prostate | Tumor | cell-substrate adhesion | 109/3246 | 363/18723 | 1.41e-09 | 6.71e-08 | 109 |
GO:007265917 | Prostate | Tumor | protein localization to plasma membrane | 90/3246 | 284/18723 | 2.07e-09 | 8.99e-08 | 90 |
GO:199077815 | Prostate | Tumor | protein localization to cell periphery | 97/3246 | 333/18723 | 5.88e-08 | 1.75e-06 | 97 |
GO:003103216 | Prostate | Tumor | actomyosin structure organization | 63/3246 | 196/18723 | 2.94e-07 | 6.72e-06 | 63 |
GO:003223118 | Prostate | Tumor | regulation of actin filament bundle assembly | 40/3246 | 105/18723 | 3.34e-07 | 7.55e-06 | 40 |
GO:000716015 | Prostate | Tumor | cell-matrix adhesion | 71/3246 | 233/18723 | 5.40e-07 | 1.16e-05 | 71 |
GO:011002019 | Prostate | Tumor | regulation of actomyosin structure organization | 38/3246 | 100/18723 | 7.01e-07 | 1.42e-05 | 38 |
GO:003003818 | Prostate | Tumor | contractile actin filament bundle assembly | 39/3246 | 106/18723 | 1.31e-06 | 2.39e-05 | 39 |
GO:004314918 | Prostate | Tumor | stress fiber assembly | 39/3246 | 106/18723 | 1.31e-06 | 2.39e-05 | 39 |
GO:005149219 | Prostate | Tumor | regulation of stress fiber assembly | 35/3246 | 91/18723 | 1.37e-06 | 2.49e-05 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPFIA1 | SNV | Missense_Mutation | | c.113N>C | p.Gln38Pro | p.Q38P | Q13136 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
PPFIA1 | SNV | Missense_Mutation | novel | c.632N>T | p.Asn211Ile | p.N211I | Q13136 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
PPFIA1 | SNV | Missense_Mutation | rs767442340 | c.1912N>A | p.Ala638Thr | p.A638T | Q13136 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD |
PPFIA1 | SNV | Missense_Mutation | novel | c.217N>T | p.His73Tyr | p.H73Y | Q13136 | protein_coding | tolerated(0.11) | possibly_damaging(0.709) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PPFIA1 | SNV | Missense_Mutation | | c.136G>A | p.Glu46Lys | p.E46K | Q13136 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPFIA1 | SNV | Missense_Mutation | | c.2240G>C | p.Arg747Thr | p.R747T | Q13136 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPFIA1 | SNV | Missense_Mutation | novel | c.2920N>C | p.Ser974Arg | p.S974R | Q13136 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
PPFIA1 | SNV | Missense_Mutation | | c.2567N>A | p.Arg856His | p.R856H | Q13136 | protein_coding | deleterious(0.02) | possibly_damaging(0.475) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
PPFIA1 | SNV | Missense_Mutation | novel | c.2071A>G | p.Ser691Gly | p.S691G | Q13136 | protein_coding | tolerated(0.38) | benign(0) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
PPFIA1 | SNV | Missense_Mutation | | c.2513N>T | p.Ser838Leu | p.S838L | Q13136 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |