Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PHB_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PHB_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PHB_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PHB_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PHB_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PHB_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PHB_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434673 | Colorectum | MSI-H | regulation of generation of precursor metabolites and energy | 21/1319 | 130/18723 | 2.90e-04 | 7.17e-03 | 21 |
GO:00336743 | Colorectum | MSI-H | positive regulation of kinase activity | 53/1319 | 467/18723 | 3.99e-04 | 8.98e-03 | 53 |
GO:00517013 | Colorectum | MSI-H | biological process involved in interaction with host | 28/1319 | 203/18723 | 4.88e-04 | 1.02e-02 | 28 |
GO:00004233 | Colorectum | MSI-H | mitophagy | 8/1319 | 28/18723 | 5.16e-04 | 1.07e-02 | 8 |
GO:00423263 | Colorectum | MSI-H | negative regulation of phosphorylation | 45/1319 | 385/18723 | 5.71e-04 | 1.14e-02 | 45 |
GO:00458603 | Colorectum | MSI-H | positive regulation of protein kinase activity | 45/1319 | 386/18723 | 6.03e-04 | 1.19e-02 | 45 |
GO:19907783 | Colorectum | MSI-H | protein localization to cell periphery | 40/1319 | 333/18723 | 6.61e-04 | 1.27e-02 | 40 |
GO:00511703 | Colorectum | MSI-H | import into nucleus | 23/1319 | 159/18723 | 7.75e-04 | 1.44e-02 | 23 |
GO:00485453 | Colorectum | MSI-H | response to steroid hormone | 40/1319 | 339/18723 | 9.37e-04 | 1.64e-02 | 40 |
GO:00101552 | Colorectum | MSI-H | regulation of proton transport | 7/1319 | 24/18723 | 1.01e-03 | 1.73e-02 | 7 |
GO:00019333 | Colorectum | MSI-H | negative regulation of protein phosphorylation | 40/1319 | 342/18723 | 1.11e-03 | 1.86e-02 | 40 |
GO:00420603 | Colorectum | MSI-H | wound healing | 47/1319 | 422/18723 | 1.23e-03 | 2.00e-02 | 47 |
GO:00066063 | Colorectum | MSI-H | protein import into nucleus | 22/1319 | 155/18723 | 1.28e-03 | 2.03e-02 | 22 |
GO:00434013 | Colorectum | MSI-H | steroid hormone mediated signaling pathway | 19/1319 | 136/18723 | 3.19e-03 | 3.93e-02 | 19 |
GO:00224113 | Colorectum | MSI-H | cellular component disassembly | 47/1319 | 443/18723 | 3.26e-03 | 3.99e-02 | 47 |
GO:00097553 | Colorectum | MSI-H | hormone-mediated signaling pathway | 24/1319 | 190/18723 | 3.88e-03 | 4.51e-02 | 24 |
GO:0009615 | Colorectum | MSI-H | response to virus | 40/1319 | 367/18723 | 3.99e-03 | 4.61e-02 | 40 |
GO:00434093 | Colorectum | MSI-H | negative regulation of MAPK cascade | 23/1319 | 180/18723 | 4.02e-03 | 4.63e-02 | 23 |
GO:00508783 | Colorectum | MSI-H | regulation of body fluid levels | 41/1319 | 379/18723 | 4.10e-03 | 4.67e-02 | 41 |
GO:00004223 | Colorectum | MSI-H | autophagy of mitochondrion | 13/1319 | 81/18723 | 4.17e-03 | 4.73e-02 | 13 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHB | SNV | Missense_Mutation | novel | c.590G>C | p.Arg197Thr | p.R197T | P35232 | protein_coding | deleterious(0.02) | possibly_damaging(0.848) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
PHB | insertion | Nonsense_Mutation | novel | c.69_70insTATTCAAAAAGAGCTTCCCAGCCCACTTCCTAGTTGGATGTGC | p.Asn24TyrfsTer11 | p.N24Yfs*11 | P35232 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHB | insertion | Nonsense_Mutation | novel | c.249_250insTTCTCATAGACAGGGAAATAAGCTCAGGTTGGCTAAGGCTTAGAGAG | p.Asp84PhefsTer3 | p.D84Ffs*3 | P35232 | protein_coding | | | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PHB | SNV | Missense_Mutation | | c.349N>T | p.Arg117Cys | p.R117C | P35232 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHB | SNV | Missense_Mutation | | c.466G>A | p.Glu156Lys | p.E156K | P35232 | protein_coding | tolerated(0.36) | benign(0.314) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PHB | SNV | Missense_Mutation | | c.347N>C | p.Glu116Ala | p.E116A | P35232 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHB | SNV | Missense_Mutation | | c.349C>T | p.Arg117Cys | p.R117C | P35232 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHB | SNV | Missense_Mutation | rs377541756 | c.626N>T | p.Ala209Val | p.A209V | P35232 | protein_coding | deleterious(0.04) | benign(0.327) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PHB | SNV | Missense_Mutation | novel | c.175C>T | p.Pro59Ser | p.P59S | P35232 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHB | SNV | Missense_Mutation | rs759272172 | c.397N>T | p.Arg133Cys | p.R133C | P35232 | protein_coding | tolerated(0.06) | benign(0.021) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |