GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00488728 | Lung | IAC | homeostasis of number of cells | 54/2061 | 272/18723 | 1.20e-05 | 3.64e-04 | 54 |
GO:00704828 | Lung | IAC | response to oxygen levels | 65/2061 | 347/18723 | 1.21e-05 | 3.64e-04 | 65 |
GO:1902043 | Lung | IAC | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | 8/2061 | 13/18723 | 1.64e-05 | 4.73e-04 | 8 |
GO:20001168 | Lung | IAC | regulation of cysteine-type endopeptidase activity | 48/2061 | 235/18723 | 1.65e-05 | 4.73e-04 | 48 |
GO:00525478 | Lung | IAC | regulation of peptidase activity | 80/2061 | 461/18723 | 2.39e-05 | 6.50e-04 | 80 |
GO:00714968 | Lung | IAC | cellular response to external stimulus | 60/2061 | 320/18723 | 2.50e-05 | 6.76e-04 | 60 |
GO:00435163 | Lung | IAC | regulation of DNA damage response, signal transduction by p53 class mediator | 13/2061 | 34/18723 | 3.34e-05 | 8.32e-04 | 13 |
GO:00432818 | Lung | IAC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 43/2061 | 209/18723 | 3.71e-05 | 9.14e-04 | 43 |
GO:00525488 | Lung | IAC | regulation of endopeptidase activity | 75/2061 | 432/18723 | 4.18e-05 | 1.01e-03 | 75 |
GO:00109528 | Lung | IAC | positive regulation of peptidase activity | 41/2061 | 197/18723 | 4.22e-05 | 1.02e-03 | 41 |
GO:20010207 | Lung | IAC | regulation of response to DNA damage stimulus | 44/2061 | 219/18723 | 5.50e-05 | 1.22e-03 | 44 |
GO:00316687 | Lung | IAC | cellular response to extracellular stimulus | 48/2061 | 246/18723 | 5.62e-05 | 1.24e-03 | 48 |
GO:00700597 | Lung | IAC | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 18/2061 | 63/18723 | 1.04e-04 | 2.02e-03 | 18 |
GO:00316696 | Lung | IAC | cellular response to nutrient levels | 41/2061 | 215/18723 | 3.13e-04 | 4.98e-03 | 41 |
GO:20012384 | Lung | IAC | positive regulation of extrinsic apoptotic signaling pathway | 14/2061 | 48/18723 | 4.72e-04 | 6.92e-03 | 14 |
GO:00316678 | Lung | IAC | response to nutrient levels | 76/2061 | 474/18723 | 4.87e-04 | 7.08e-03 | 76 |
GO:20012355 | Lung | IAC | positive regulation of apoptotic signaling pathway | 27/2061 | 126/18723 | 5.01e-04 | 7.25e-03 | 27 |
GO:00109508 | Lung | IAC | positive regulation of endopeptidase activity | 35/2061 | 179/18723 | 5.15e-04 | 7.37e-03 | 35 |
GO:00349768 | Lung | IAC | response to endoplasmic reticulum stress | 46/2061 | 256/18723 | 5.58e-04 | 7.76e-03 | 46 |
GO:00096156 | Lung | IAC | response to virus | 61/2061 | 367/18723 | 6.75e-04 | 9.12e-03 | 61 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAIP1 | SNV | Missense_Mutation | | c.742N>T | p.Val248Phe | p.V248F | Q8WWC4 | protein_coding | tolerated(0.08) | benign(0.233) | TCGA-A8-A08S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MAIP1 | SNV | Missense_Mutation | | c.340N>A | p.Gly114Arg | p.G114R | Q8WWC4 | protein_coding | deleterious(0.03) | possibly_damaging(0.905) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.608N>C | p.Phe203Ser | p.F203S | Q8WWC4 | protein_coding | deleterious(0) | benign(0.091) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.781N>A | p.Leu261Ile | p.L261I | Q8WWC4 | protein_coding | tolerated(0.07) | possibly_damaging(0.521) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | | c.363N>T | p.Trp121Cys | p.W121C | Q8WWC4 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
MAIP1 | SNV | Missense_Mutation | | c.520G>C | p.Glu174Gln | p.E174Q | Q8WWC4 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.607_608insCTCA | p.Phe203SerfsTer13 | p.F203Sfs*13 | Q8WWC4 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.646_647insTGGC | p.Lys216MetfsTer8 | p.K216Mfs*8 | Q8WWC4 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.647_648insGCCTAGATTTC | p.Gly217ProfsTer12 | p.G217Pfs*12 | Q8WWC4 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.37N>T | p.His13Tyr | p.H13Y | Q8WWC4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.006) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |