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Gene: LSM14A |
Gene summary for LSM14A |
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Gene information | Species | Human | Gene symbol | LSM14A | Gene ID | 26065 |
Gene name | LSM14A mRNA processing body assembly factor | |
Gene Alias | C19orf13 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8ND56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26065 | LSM14A | CA_HPV_3 | Human | Cervix | CC | 1.29e-02 | 1.01e-01 | 0.0414 |
26065 | LSM14A | CCI_1 | Human | Cervix | CC | 1.72e-02 | 4.84e-01 | 0.528 |
26065 | LSM14A | CCI_2 | Human | Cervix | CC | 2.28e-06 | 7.43e-01 | 0.5249 |
26065 | LSM14A | CCI_3 | Human | Cervix | CC | 2.90e-04 | 6.28e-01 | 0.516 |
26065 | LSM14A | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-09 | -4.16e-01 | 0.0155 |
26065 | LSM14A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.83e-02 | 4.43e-01 | 0.281 |
26065 | LSM14A | A001-C-207 | Human | Colorectum | FAP | 1.10e-03 | -2.48e-01 | 0.1278 |
26065 | LSM14A | A015-C-203 | Human | Colorectum | FAP | 1.51e-26 | -4.68e-01 | -0.1294 |
26065 | LSM14A | A015-C-204 | Human | Colorectum | FAP | 3.00e-08 | -2.24e-01 | -0.0228 |
26065 | LSM14A | A014-C-040 | Human | Colorectum | FAP | 8.16e-07 | -5.55e-01 | -0.1184 |
26065 | LSM14A | A002-C-201 | Human | Colorectum | FAP | 4.07e-16 | -3.64e-01 | 0.0324 |
26065 | LSM14A | A002-C-203 | Human | Colorectum | FAP | 1.04e-05 | -1.76e-01 | 0.2786 |
26065 | LSM14A | A001-C-119 | Human | Colorectum | FAP | 2.04e-08 | -3.36e-01 | -0.1557 |
26065 | LSM14A | A001-C-108 | Human | Colorectum | FAP | 4.55e-19 | -3.33e-01 | -0.0272 |
26065 | LSM14A | A002-C-205 | Human | Colorectum | FAP | 2.57e-26 | -4.64e-01 | -0.1236 |
26065 | LSM14A | A014-C-108 | Human | Colorectum | FAP | 2.75e-03 | -4.01e-01 | -0.124 |
26065 | LSM14A | A001-C-104 | Human | Colorectum | FAP | 2.27e-09 | -3.63e-01 | 0.0184 |
26065 | LSM14A | A015-C-005 | Human | Colorectum | FAP | 2.26e-07 | -3.65e-01 | -0.0336 |
26065 | LSM14A | A015-C-006 | Human | Colorectum | FAP | 4.76e-18 | -4.91e-01 | -0.0994 |
26065 | LSM14A | A015-C-106 | Human | Colorectum | FAP | 3.04e-11 | -2.80e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003210324 | Thyroid | ATC | positive regulation of response to external stimulus | 178/6293 | 427/18723 | 2.61e-04 | 1.67e-03 | 178 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
GO:006075912 | Thyroid | ATC | regulation of response to cytokine stimulus | 76/6293 | 162/18723 | 2.92e-04 | 1.85e-03 | 76 |
GO:009858615 | Thyroid | ATC | cellular response to virus | 44/6293 | 84/18723 | 2.94e-04 | 1.87e-03 | 44 |
GO:000195912 | Thyroid | ATC | regulation of cytokine-mediated signaling pathway | 71/6293 | 150/18723 | 3.28e-04 | 2.04e-03 | 71 |
GO:000196112 | Thyroid | ATC | positive regulation of cytokine-mediated signaling pathway | 29/6293 | 50/18723 | 3.42e-04 | 2.12e-03 | 29 |
GO:003952914 | Thyroid | ATC | RIG-I signaling pathway | 18/6293 | 27/18723 | 4.53e-04 | 2.68e-03 | 18 |
GO:005160712 | Thyroid | ATC | defense response to virus | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:014054612 | Thyroid | ATC | defense response to symbiont | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:001714823 | Thyroid | ATC | negative regulation of translation | 107/6293 | 245/18723 | 6.17e-04 | 3.51e-03 | 107 |
GO:006033811 | Thyroid | ATC | regulation of type I interferon-mediated signaling pathway | 22/6293 | 36/18723 | 6.58e-04 | 3.73e-03 | 22 |
GO:004508813 | Thyroid | ATC | regulation of innate immune response | 94/6293 | 218/18723 | 2.05e-03 | 9.71e-03 | 94 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LSM14A | SNV | Missense_Mutation | c.1180N>A | p.Glu394Lys | p.E394K | Q8ND56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LSM14A | deletion | In_Frame_Del | novel | c.104_118delCCGTAGCCCTTGCCA | p.Thr35_Ala39del | p.T35_A39del | Q8ND56 | protein_coding | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
LSM14A | SNV | Missense_Mutation | novel | c.1345N>C | p.Glu449Gln | p.E449Q | Q8ND56 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.584) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LSM14A | SNV | Missense_Mutation | novel | c.1312C>T | p.Arg438Cys | p.R438C | Q8ND56 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.648) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LSM14A | SNV | Missense_Mutation | c.580N>G | p.Thr194Ala | p.T194A | Q8ND56 | protein_coding | tolerated(0.1) | benign(0.083) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LSM14A | SNV | Missense_Mutation | rs377088182 | c.158N>A | p.Arg53His | p.R53H | Q8ND56 | protein_coding | tolerated(0.05) | possibly_damaging(0.76) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
LSM14A | SNV | Missense_Mutation | c.526C>A | p.Gln176Lys | p.Q176K | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.392) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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