Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: FITM2

Gene summary for FITM2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FITM2

Gene ID

128486

Gene namefat storage inducing transmembrane protein 2
Gene AliasC20orf142
Cytomap20q13.12
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q8N6M3


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
128486FITM2HCC1_MengHumanLiverHCC2.58e-353.85e-020.0246
128486FITM2HCC2_MengHumanLiverHCC1.15e-031.57e-020.0107
128486FITM2HCC1HumanLiverHCC2.01e-253.72e+000.5336
128486FITM2HCC2HumanLiverHCC1.52e-283.08e+000.5341
128486FITM2HCC5HumanLiverHCC4.17e-352.32e+000.4932
128486FITM2S014HumanLiverHCC4.70e-114.60e-010.2254
128486FITM2S015HumanLiverHCC3.65e-177.33e-010.2375
128486FITM2S016HumanLiverHCC6.51e-216.43e-010.2243
128486FITM2S028HumanLiverHCC2.16e-041.58e-010.2503
128486FITM2S029HumanLiverHCC2.00e-031.56e-010.2581
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00096156LungIACresponse to virus61/2061367/187236.75e-049.12e-0361
GO:00465963LungIACregulation of viral entry into host cell12/206142/187231.44e-031.55e-0212
GO:00354551LungIACresponse to interferon-alpha7/206121/187235.59e-034.12e-027
GO:001603213LungAISviral process85/1849415/187234.74e-111.95e-0885
GO:001905813LungAISviral life cycle68/1849317/187235.39e-101.16e-0768
GO:004671813LungAISviral entry into host cell38/1849144/187231.13e-081.68e-0638
GO:005212613LungAISmovement in host environment43/1849175/187231.29e-081.88e-0643
GO:005170113LungAISbiological process involved in interaction with host47/1849203/187232.09e-082.90e-0647
GO:004440913LungAISentry into host38/1849151/187234.50e-085.24e-0638
GO:004440313LungAISbiological process involved in symbiotic interaction58/1849290/187231.33e-071.44e-0558
GO:005079213LungAISregulation of viral process32/1849164/187231.33e-042.97e-0332
GO:004390312LungAISregulation of biological process involved in symbiotic interaction16/184972/187231.50e-031.81e-0216
GO:001907913LungAISviral genome replication24/1849131/187232.14e-032.30e-0224
GO:005237212LungAISmodulation by symbiont of entry into host12/184949/187232.39e-032.48e-0212
GO:190390013LungAISregulation of viral life cycle26/1849148/187232.64e-032.68e-0226
GO:001905823LungAAHviral life cycle21/613317/187231.85e-034.31e-0221
GO:001905833LungMIACviral life cycle36/967317/187238.00e-067.07e-0436
GO:005212623LungMIACmovement in host environment23/967175/187233.58e-051.97e-0323
GO:004671823LungMIACviral entry into host cell19/967144/187231.58e-046.13e-0319
GO:001603223LungMIACviral process39/967415/187232.34e-047.89e-0339
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FITM2SNVMissense_Mutationc.645N>Ap.Asn215Lysp.N215KQ8N6M3protein_codingdeleterious(0)benign(0.089)TCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
FITM2insertionFrame_Shift_Insnovelc.72_73insGCGAACCTCGTCTCTTCTAAAAp.Pro25AlafsTer134p.P25Afs*134Q8N6M3protein_codingTCGA-AN-A0FK-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
FITM2insertionFrame_Shift_Insnovelc.70_71insAGCCTGTCCAACAp.Leu24GlnfsTer132p.L24Qfs*132Q8N6M3protein_codingTCGA-AN-A0FK-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
FITM2SNVMissense_Mutationrs370245406c.487N>Ap.Ala163Thrp.A163TQ8N6M3protein_codingtolerated(0.26)benign(0.04)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
FITM2SNVMissense_Mutationrs771219892c.253N>Ap.Gly85Serp.G85SQ8N6M3protein_codingtolerated(0.43)possibly_damaging(0.593)TCGA-CM-6162-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyoxaliplatinSD
FITM2SNVMissense_Mutationnovelc.118N>Ap.Glu40Lysp.E40KQ8N6M3protein_codingdeleterious(0.02)possibly_damaging(0.631)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
FITM2SNVMissense_Mutationnovelc.581N>Tp.Ala194Valp.A194VQ8N6M3protein_codingdeleterious(0)possibly_damaging(0.611)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
FITM2SNVMissense_Mutationnovelc.152N>Gp.Asn51Serp.N51SQ8N6M3protein_codingtolerated(0.42)benign(0.112)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
FITM2SNVMissense_Mutationrs755374181c.539N>Ap.Arg180Glnp.R180QQ8N6M3protein_codingtolerated(0.4)possibly_damaging(0.849)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
FITM2SNVMissense_Mutationnovelc.499G>Ap.Val167Ilep.V167IQ8N6M3protein_codingtolerated(0.19)benign(0.038)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
Page: 1 2 3 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1